Nanoscale Systems for Local Activation of Hypoxia-Inducible Factor-1 Alpha: A New Approach in Diabetic Wound Management

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13735 - 13762

Published: Dec. 1, 2024

Chronic wounds in diabetic patients experience significant clinical challenges due to compromised healing processes. Hypoxia-inducible factor-1 alpha (HIF-1α) is a critical regulator the cellular response hypoxia, enhancing angiogenesis and tissue restoration. Nevertheless, developed chronic hypoxia within diabetes impaired, likely destabilization of HIF-1α via degradation by prolyl hydroxylase domain (PHD) enzymes. Researchers have extensively explored activation as potential pathway for wound management, focusing mainly on deferoxamine (DFO) potent agent stabilize HIF-1α. This review provides an update other recent pharmacological agents managing activation, including novel PHD inhibitors (roxadustat daprodustat) Von Hippel-Lindau protein (VHL) antagonists, which could be alternatives local treatment wounds. Furthermore, it highlights how localized delivery advanced nanostructures can enhance efficacy these therapies. Importantly, addressing points, current offer promising area research. Given that, drugs minimal applications healing, particularly context application through nanomaterials. gap presents exciting opportunity further investigation, combining with nanotechnology avoid undesired systemic side effects sustain drug release site, offering transformative platform treatment.

Language: Английский

Dandelion-shaped strontium-gallium microparticles for the hierarchical stimulation and comprehensive regulation of wound healing

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract The management of full-thickness skin injuries continues to pose significant challenges. Currently, there is a dearth comprehensive dressings capable integrating all stages wound healing spatiotemporally regulate biological processes following injuries. In this study, we report the synthesis dandelion-shaped mesoporous strontium-gallium microparticle (GE@SrTPP) achieved through dopamine-mediated strontium ion biomineralization and self-assembly, followed by functionalization with gallium metal polyphenol networks. As multifunctional dressing, GE@SrTPP can release bioactive ions in spatiotemporal manner akin dandelion seeds. During early healing, demonstrates rapid effective hemostatic performance while also exhibiting antibacterial properties. inflammatory phase, promotes M2 polarization macrophages, suppresses expression pro-inflammatory factors, decreases oxidative stress wounds. Subsequently, during proliferation tissue remodeling, facilitates angiogenesis activation Hypoxia-inducible factor-1α/vascular endothelial growth factor (HIF-1α/VEGF) pathway. Analogous dispersion rooting seeds, root-like new blood vessels supply essential nutrients for healing. Ultimately, rat chronic model, successful repair. summary, these microparticles demonstrate regulatory effects managing wounds, making them highly promising materials clinical applications.

Language: Английский

Silk fibroin/gelatin electrospun nanofibrous dressing loaded with Roxadustat accelerates wound healing in diabetic rats via HIF-1α stabilization

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106439 - 106439

Published: Nov. 1, 2024

Language: Английский