Recent advancements in polyethyleneimine (PEI)-grafted materials and composites as versatile adsorbents for water detoxification

Macromolecular Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

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Cinnamaldehyde-Based ROS-Responsive Polymeric Gene Vectors for Efficient Gene Delivery and Tumor Cell Growth Inhibition

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Reactive oxygen species (ROS)-sensitive polymers are extensively used in cancer therapies. However, the ROS levels tumor microenvironment often insufficient to trigger an adequate therapeutic response. Herein, we report a cinnamaldehyde (CA)-based ROS-responsive cationic polymer (PCA) and demonstrate its high efficiency gene delivery cell growth inhibition. CA could be released from via ROS-sensitive thioacetal bond by endogenous ROS. The successively induced more accumulation through GSH depletion, positive feedback helped PCA achieve self-accelerating degradation. Results proved that PCA/p53 complexes were efficient depleting GSH, upregulating levels, transfection. Besides, was also shown effective delivering p53. More importantly, significantly induce suppression synergistic effect of p53, providing valuable insights into design self-amplifying polymeric vectors.

Language: Английский

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Tannic acid cross-linked polyethylenimine quantum dot nanoclusters for efficient DNA release

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143055 - 143055

Published: April 1, 2025

Language: Английский

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Integrated cell membrane encapsulated PQDs-TK quantum dot nanoclusters with ROS-responsive triggering for efficient and visualized DNA delivery

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 683, P. 393 - 410

Published: Dec. 25, 2024

Language: Английский

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