Antiviral Activity of Rhamnolipids Nano-Micelles Against Rhinoviruses—In Silico Docking, Molecular Dynamic Analysis and In-Vitro Studies DOI Creative Commons

Lila Touabi,

Nasser S. M. Ismail, Marwa Reda Bakkar

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(5), P. 333 - 333

Published: May 6, 2025

Hospital-acquired infections (HAIs) previously focused mainly on multidrug-resistant (MDR) bacteria, with less attention viruses. The COVID-19 pandemic highlighted the importance of controlling viral infections. Human rhinoviruses (HRVs) are among viruses responsible for HAIs. HRVs non-enveloped that infect upper airways after airborne or direct transmission. Due to their lack a membrane envelope, exhibit moderate resistance commonly applied alcoholic disinfectants. Therefore, there is significant need develop alternative disinfection and hand sanitation strategies control HRV in healthcare settings without posing risk human health. antimicrobial activity safety rhamnolipids nano-micelles (RMN) against MDR-bacteria several viruses, including SARS-CoV-2, were confirmed recently. Also, we demonstrated superior RMN over rhamnolipids. In current study, molecular docking weak interactions HRV-1A (minor group) compared HRV-14 (major group), suggesting antiviral towards major group rhinoviruses. To biologically validate these data, was prepared characterized, then HRV-16 HRV-1B infection HeLa cells assessed. showed complete inhibition recovery 100% cell viability. contrast, only partial approximately 50% protection observed. might be recommended as disinfectant and/or sanitizer component spread RVs hospital care elsewhere reduce incidence respiratory

Language: Английский

Determination of Particle Mixture Composition by Visible Spectroscopy DOI Creative Commons
Mauricio Escudey, Lizethly Cáceres-Jensen, Manuel Gacitúa

et al.

Colloids and Interfaces, Journal Year: 2025, Volume and Issue: 9(2), P. 16 - 16

Published: March 12, 2025

Limited methods exist to determine the composition of particle mixtures. This research presents a simple UV-vis-spectroscopy-based method for separate quantification particles mixtures considering following: synthesized ferrihydrite, commercial Fe2O3, and natural allophane. Calibration curves adsorption/scattering coefficients are determined each at different wavelengths. is main input solve equation systems and, ultimately, quantify concentration in binary The limit detection varies with wavelength type, yielding values as low 1.5, 0.2, 1.6 mg L−1 ferrihydrite (500 nm), Fe2O3 (450 allophane respectively. study provides simple, low-cost straightforward method, compared atomic-spectroscopy- or chromatography-based techniques, resolving suspension.

Language: Английский

Citations

0
Synthesis of a Novel Supermagnetic Fe3O4 Nanoparticles and their Congo Red Dye Removal, Cytotoxic, Antioxidant, and Antimicrobial Activities DOI Creative Commons
Semih Gökdağ, Fatma Caf, Fulya Doğaner

et al.

Plasmonics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Language: Английский

Citations

0
Antiviral Activity of Rhamnolipids Nano-Micelles Against Rhinoviruses—In Silico Docking, Molecular Dynamic Analysis and In-Vitro Studies DOI Creative Commons

Lila Touabi,

Nasser S. M. Ismail, Marwa Reda Bakkar

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(5), P. 333 - 333

Published: May 6, 2025

Hospital-acquired infections (HAIs) previously focused mainly on multidrug-resistant (MDR) bacteria, with less attention viruses. The COVID-19 pandemic highlighted the importance of controlling viral infections. Human rhinoviruses (HRVs) are among viruses responsible for HAIs. HRVs non-enveloped that infect upper airways after airborne or direct transmission. Due to their lack a membrane envelope, exhibit moderate resistance commonly applied alcoholic disinfectants. Therefore, there is significant need develop alternative disinfection and hand sanitation strategies control HRV in healthcare settings without posing risk human health. antimicrobial activity safety rhamnolipids nano-micelles (RMN) against MDR-bacteria several viruses, including SARS-CoV-2, were confirmed recently. Also, we demonstrated superior RMN over rhamnolipids. In current study, molecular docking weak interactions HRV-1A (minor group) compared HRV-14 (major group), suggesting antiviral towards major group rhinoviruses. To biologically validate these data, was prepared characterized, then HRV-16 HRV-1B infection HeLa cells assessed. showed complete inhibition recovery 100% cell viability. contrast, only partial approximately 50% protection observed. might be recommended as disinfectant and/or sanitizer component spread RVs hospital care elsewhere reduce incidence respiratory

Language: Английский

Citations

0