Evaluation of Drug Permeation Enhancement by Using In Vitro and Ex Vivo Models

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 195 - 195

Published: Jan. 31, 2025

Drugs administered by means of extravascular routes drug administration must be absorbed into the systemic circulation, which involves movement molecules across biological barriers such as epithelial cells that cover mucosal surfaces or stratum corneum covers skin. Some drugs exhibit poor permeation membranes may experience excessive degradation during first-pass metabolism, tends to limit their bioavailability. Various strategies have been used improve Absorption enhancement include co-administration chemical enhancers, enzymes, and/or efflux transporter inhibitors, changes, and specialized dosage form designs. Models with physiological relevance are needed evaluate efficacy absorption techniques. in vitro cell culture models ex vivo tissue explored quantify effectiveness strategies. This review deliberates on use for evaluation selected including nasal, oromucosal, pulmonary, oral, rectal, transdermal administration.

Language: Английский

Enhanced skin adhesion of transdermal drug delivery system a semi-IPN strategy: / evaluation and drug release mechanism

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114662 - 114662

Published: April 1, 2025

Language: Английский