Novel Bioactive Resin Coating with Calcium Phosphate Nanoparticles for Antibacterial and Remineralization Abilities to Combat Tooth Root Caries DOI Open Access
Nader Almutairi, Abdullah Alhussein, Mohammad Alenizy

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2490 - 2490

Published: March 11, 2025

Tooth root caries account for 10.1% of all dental in the USA. This study developed a multifunctional resin coating with calcium (Ca) and phosphate (P) ion release antibacterial properties to combat caries. The effects nano-sized amorphous (NACP) dimethylaminohexadecyl methacrylate (DMAHDM) on mechanical, physical, against Streptococcus mutans, cytotoxicity pulp stem cells gingival fibroblasts were evaluated. A combining urethane dimethacrylate (UDMA), triethylene glycol divinylbenzyl ether (TEGDVBE), DMAHDM, NACP was synthesized compared Seal&Protect Vanish XT. Experimental groups (UV + 5% DMAHDM 10%, 15%, 20% NACP) showed flexural strength (70.9 ± 8.0 81.1 6.0) MPa, significantly higher than (48.2 7.2) MPa (p < 0.05) comparable XT (70.2 13.6) > 0.05). Elastic modulus (2.2 3.3) GPa lower (9.4 1.1) an 8 log CFU reduction, 96% reduction metabolic activity 87% lactic acid production, increased Ca (1.25 0.03) mmol/L P (0.8 0.001) over 35 days. Cytotoxicity experimental human fibroblast low matched those commercial controls already used clinic. demonstrated potent properties, high release, cytotoxicity, maintained physical mechanical integrity, offering potential prevent formation progression.

Language: Английский

Novel Bioactive Resin Coating with Calcium Phosphate Nanoparticles for Antibacterial and Remineralization Abilities to Combat Tooth Root Caries DOI Open Access
Nader Almutairi, Abdullah Alhussein, Mohammad Alenizy

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2490 - 2490

Published: March 11, 2025

Tooth root caries account for 10.1% of all dental in the USA. This study developed a multifunctional resin coating with calcium (Ca) and phosphate (P) ion release antibacterial properties to combat caries. The effects nano-sized amorphous (NACP) dimethylaminohexadecyl methacrylate (DMAHDM) on mechanical, physical, against Streptococcus mutans, cytotoxicity pulp stem cells gingival fibroblasts were evaluated. A combining urethane dimethacrylate (UDMA), triethylene glycol divinylbenzyl ether (TEGDVBE), DMAHDM, NACP was synthesized compared Seal&Protect Vanish XT. Experimental groups (UV + 5% DMAHDM 10%, 15%, 20% NACP) showed flexural strength (70.9 ± 8.0 81.1 6.0) MPa, significantly higher than (48.2 7.2) MPa (p < 0.05) comparable XT (70.2 13.6) > 0.05). Elastic modulus (2.2 3.3) GPa lower (9.4 1.1) an 8 log CFU reduction, 96% reduction metabolic activity 87% lactic acid production, increased Ca (1.25 0.03) mmol/L P (0.8 0.001) over 35 days. Cytotoxicity experimental human fibroblast low matched those commercial controls already used clinic. demonstrated potent properties, high release, cytotoxicity, maintained physical mechanical integrity, offering potential prevent formation progression.

Language: Английский

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