Reviews in the Neurosciences, Journal Year: 2025, Volume and Issue: unknown
Published: April 14, 2025
Abstract Diabetic peripheral neuropathy (DPN) is a serious complication of diabetes mellitus, which common cause disability in individuals with mellitus. Multiple mechanisms may be involved the development DPN. Neuroinflammation critical factor contributing to nerve damage during diabetes. Inflammation can induce and long-term hyperglycemia also causes increased oxidative stress promotes release inflammatory cytokines. After reading through literature, association inflammation induction DPN was discussed review. induces conduction impairment. The neuropathic pain diabetes-induced closely associated response. Given important roles DPN, explicit elucidation neuroinflammation mellitus should hold potential for developing novel therapeutic strategies Experimental studies limited clinical trials support value anti-inflammatory reagents treating positive outcomes these investigations warrant further trials.
Language: Английский