Green-synthesized silver nanoparticles induced apoptotic cell death in CACO2 cancer cells by activating MLH1 gene expression DOI Creative Commons

Hamideh Khajeh,

Bahman Fazeli‐Nasab,

Afsaneh Pourshahdad

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 28, 2024

MLH1 (Mult homolog1) gene is the main element of Multlα heterodimer and plays a role in repair base-base mismatches deletion addition loops. When protein not present, number errors that remain unrepaired increases, this can lead to formation tumors body. Colorectal cancer third most common type terms incidence mortality worldwide. In regard, present study was conducted with aim investigating effect biological silver nanoparticles anticancer properties expression on cell samples people colorectal cancer. study, green synthesis carried out by precipitation method reduction ions leaf flower extract Moringa oleifera plant. Then, were confirmed using UV-visible spectroscopy, transmission scanning electron microscopy. The cytotoxic effects cells evaluated MTT colorimetric within 42 h. After RNA extraction treated cells, cDNA primers designed Exon-Exon Junction Real-time Polymerase test for Beta-actin genes repeated three times. final analysis results done Graphpad Prism Rest 2009 software. presence peak at wavelength 234 nm synthesized ultraviolet-visible spectroscopic analysis. morphological size shape showed are spherical have between 40 34 nanometers diameter. typically produces smaller, more uniform particles than extract. Green-Synthesized Silver Nanoparticles used evaluation induced Apoptotic Cell Death CACO2 Cancer Cells Activating Gene Expression. anti-proliferative depends concentration nanoparticles. treatment line normal 0.44 micrograms per ml h toxicity. percentage death under influence quercetin bio-particles time, difference statistically significant compared control group (P < 0.05). So lethal dose 50% survival IC50 period 48 intestinal equal 21 μg/ml, ratio tumor tissue adjacent healthy has increased ≤

Language: Английский

In Silico Simulation of Daphnia magna Immobilization Exposed to Mixtures of TiO2 Nanoparticles with Inorganic Compounds DOI Open Access
Alla P. Toropova, Andrey A. Toropov, Alessandra Roncaglioni

et al.

Journal of Composites Science, Journal Year: 2025, Volume and Issue: 9(1), P. 16 - 16

Published: Jan. 2, 2025

The development of models the physicochemical and biochemical behavior nanomaterials is useful for improving evaluation management this material. Quasi-SMILES technology makes it possible to quite successfully cope with kind modeling task, accounting various experimental conditions, where use other approaches difficult or even impossible. Here, we describe results using quasi-SMILES model toxicity mixtures titanium nano oxide inorganic substances towards Daphnia magna. approach based on stochastic process optimization correlation weights different codes used in quasi-SMILES. was carried out special statistical criteria predictive potential. It shown that built have best

Language: Английский

Citations

0
Nanotechnology in agriculture: enhancing crop productivity and addressing toxicity in plants and algae DOI
Sanjesh Tiwari, Anuradha Patel, Vaishali Yadav

et al.

Nanotechnology for Environmental Engineering, Journal Year: 2025, Volume and Issue: 10(2)

Published: April 30, 2025

Language: Английский

Citations

0
Diversity of copper-containing nanoparticles and their influence on plant growth and development DOI
А. I. Perfileva, Б. Г. Сухов, Т. В. Конькова

et al.

Plant Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109575 - 109575

Published: Jan. 1, 2025

Language: Английский

Citations

0
Distribution, environmental behavior, and ecotoxicity of different metal oxide nanoparticles in the aquatic environment DOI

Fengping Yu,

Jingtian Gao,

Peng Zhang

et al.

Process Safety and Environmental Protection, Journal Year: 2025, Volume and Issue: unknown, P. 106856 - 106856

Published: Feb. 1, 2025

Language: Английский

Citations

0
Nanomaterial-Based Biofortification: Potential Benefits and Impacts of Crops DOI
Erico R. Carmona,

Cynthia Rojo,

Víctor Manuel Vergara Carmona

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Nanomaterials (NMs) have shown relevant impacts in crop protection, improvement of yields, and minimizing collateral side effects fertilizer pesticides vegetable fruit production. The application NMs to improve biofortification has gained much attention the last five years, offering a hopeful optimistic outlook. Thus, we propose comprehensively revising scientific literature about use agronomic crops analyzing beneficial impact NMs. results indicated that different species plants were biofortified with essential elements macronutrients after applications Zn, Fe, Se, nanocomposites, metalloid NPs. In addition, physiological performances, antioxidant compounds, yields improved Using nanofertilizers for can be considered promising method deliver micronutrients on human health, environment, agriculture.

Language: Английский

Citations

2
Green-synthesized silver nanoparticles induced apoptotic cell death in CACO2 cancer cells by activating MLH1 gene expression DOI Creative Commons

Hamideh Khajeh,

Bahman Fazeli‐Nasab,

Afsaneh Pourshahdad

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 28, 2024

MLH1 (Mult homolog1) gene is the main element of Multlα heterodimer and plays a role in repair base-base mismatches deletion addition loops. When protein not present, number errors that remain unrepaired increases, this can lead to formation tumors body. Colorectal cancer third most common type terms incidence mortality worldwide. In regard, present study was conducted with aim investigating effect biological silver nanoparticles anticancer properties expression on cell samples people colorectal cancer. study, green synthesis carried out by precipitation method reduction ions leaf flower extract Moringa oleifera plant. Then, were confirmed using UV-visible spectroscopy, transmission scanning electron microscopy. The cytotoxic effects cells evaluated MTT colorimetric within 42 h. After RNA extraction treated cells, cDNA primers designed Exon-Exon Junction Real-time Polymerase test for Beta-actin genes repeated three times. final analysis results done Graphpad Prism Rest 2009 software. presence peak at wavelength 234 nm synthesized ultraviolet-visible spectroscopic analysis. morphological size shape showed are spherical have between 40 34 nanometers diameter. typically produces smaller, more uniform particles than extract. Green-Synthesized Silver Nanoparticles used evaluation induced Apoptotic Cell Death CACO2 Cancer Cells Activating Gene Expression. anti-proliferative depends concentration nanoparticles. treatment line normal 0.44 micrograms per ml h toxicity. percentage death under influence quercetin bio-particles time, difference statistically significant compared control group (P < 0.05). So lethal dose 50% survival IC50 period 48 intestinal equal 21 μg/ml, ratio tumor tissue adjacent healthy has increased ≤

Language: Английский

Citations

0