Toxics,
Journal Year:
2024,
Volume and Issue:
12(10), P. 754 - 754
Published: Oct. 17, 2024
The
lanthanide
series
elements
are
transition
metals
used
as
critical
components
of
electronics,
well
rechargeable
batteries,
fertilizers,
antimicrobials,
contrast
agents
for
medical
imaging,
and
diesel
fuel
additives.
With
the
surge
in
their
utilization,
being
found
more
our
environment.
However,
little
is
known
about
health
effects
associated
with
exposure.
Epidemiological
studies
performed
rodents
exposed
to
lanthanum
(La)
suggest
neurological
damage,
learning
memory
impairment,
disruption
neurotransmitter
signaling,
particularly
serotonin
dopamine
pathways.
Unfortunately,
heavier
lanthanides.
As
dysfunctions
serotonergic
dopaminergic
signaling
implicated
multiple
conditions,
including
Parkinson’s
disease,
depression,
generalized
anxiety
disorder,
post-traumatic
stress
it
utmost
importance
determine
La
other
lanthanides
on
these
systems.
We
therefore
hypothesized
that
early-life
exposure
light
[La
(III)
or
cerium
(Ce
(III))]
heavy
[erbium
(Er
(III))
ytterbium
(Yb
Caenorhabditis
elegans
could
cause
dysregulation
upon
adulthood.
Serotonergic
was
assessed
by
measuring
pharyngeal
pump
rate,
crawl-to-swim
transition,
egg-laying
behaviors.
Dopaminergic
locomotor
rate
swim-to-crawl
Treatment
(III),
Ce
Er
Yb
caused
deficits
all
assays,
suggesting
both
disrupt
Concomitant
neurotransmission,
four
increased
reactive
oxygen
species
(ROS)
generation
decreased
glutathione
ATP
levels.
This
suggests
oxidative
stress,
which
a
modifier
neurotransmission.
Altogether,
data
may
affect
development
pharmacological
management
related
conditions.
