Removal of Antibiotic Resistance from Wastewater in Aquatic Ecosystems Dominated by Submerged Macrophytes

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137706 - 137706

Published: Feb. 21, 2025

Language: Английский

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Mechanisms of Neurotoxicity of Organophosphate Pesticides and Their Relation to Neurological Disorders

Neuropsychiatric Disease and Treatment, Journal Year: 2024, Volume and Issue: Volume 20, P. 2237 - 2254

Published: Nov. 1, 2024

Organophosphates (OPs) refers to a diverse group of phosphorus-containing organic compounds; they are widely used all over the world and have had an important beneficial impact on industrial agricultural production control vector transmission. Exposure OPs different toxicities (high, moderate, slight, low toxicity) can negative consequences nervous system, such as nausea, vomiting, muscle tremors, convulsions. In severe cases, it lead respiratory failure or even death. Notably, induce neuropathy in system through specific interactions with nicotinic muscarinic receptors, phosphorylating acetylcholinesterase, neuropathic target esterases. This review summarizes possible toxicological mechanisms their interplay underlying OP pesticide poisoning, including cholinesterase inhibition non-cholinesterase mechanisms. It outlines links between poisoning neurological disorders, dementia, neurodevelopmental diseases, Parkinson's disease. Additionally, explores interactions' potential therapeutic implications that may help mitigate deleterious system.

Language: Английский

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Cybertoxicology, molecular docking, and experimental verification reveal the mechanism of action of chlorpyrifos on skin damage

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117587 - 117587

Published: Jan. 1, 2025

Chlorpyrifos (CPF) is a broad-spectrum organophosphate chloride (OP) insecticide widely used in domestic use and open field. However, there currently no relevant research revealing the toxic effects of CPF exposure on skin, then it necessary to comprehensively understand mechanisms. The results showed that skin tissue structure function mice were significantly disrupted after exposure. Furthermore, PPI network analysis molecular docking experiments pinpointed core targets such as Bcl2, EGFR, Caspase-3, TNF-α, IL-1β, VEGF. Additionally, through KEGG analysis, VEGF apoptosis signaling pathways identified pivotal implicated CPF-induced toxicity. These subsequently confirmed animal experimentation. In conclusion, our study suggests primarily induces damage by disrupting function, mediated proliferation processes cells, alongside aberrant angiogenesis heightened inflammatory response. insights are expected advance development preventive therapeutic strategies aimed at mitigating adverse skin.

Language: Английский

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BIOREMEDIATION: A SUPERIOR ALTERNATIVE FOR REMEDIATING TANNERY EFFLUENT-CONTAMINATED SOIL

FUDMA Journal of Sciences, Journal Year: 2025, Volume and Issue: 9(2), P. 193 - 208

Published: Feb. 28, 2025

Tannery effluent poses significant risks to soil health, primarily through contamination with heavy metals like chromium, sulphides, and persistent organic pollutants (POPs). These toxic substances inhibit microbial activity, reducing nutrient cycling matter decomposition essential for fertility. Beneficial microorganisms, including nitrogen-fixing bacteria, are particularly affected, leading altered communities dominated by less advantageous, metal-tolerant species. Accumulation of POPs disrupts enzymatic activities, interferes plant root growth, complicates remediation efforts due pollutant migration groundwater potential entry into the food chain. Prolonged exposure such contaminants diminishes fertility, reduces resilience, ecosystem services, posing threats agricultural productivity environmental health. This review was aimed outline what made bioremediation a superior treatment technology among other methods used in remediating tannery contaminated soil. Efforts mitigate impacts involve combination physical, chemical, biological technologies. Physical washing, flushing, thermal desorption focus on removing or isolating contaminants, while chemical approaches as oxidation, reduction, stabilization transform harmful forms immobilize them. Biological leverages microorganisms plants detoxify sustainably. Bioremediation strategies aid bioaugmentation biostimulation do enhance activity address inorganic effectively more than physical methods. Another excellent called phytoremediation can also effectively, Achieving better technique should be coupled stringent industrial regulations, sustainable tanning methods, stakeholder awareness

Language: Английский

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Dual-mode sensors based on double enzyme-mimicking MnCu nanoflowers as fluorescence probe for the detection of organophosphorus pesticides and 2,4-dichlorophenol

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 251, P. 114608 - 114608

Published: March 12, 2025

Language: Английский

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Evaluation of the treatment effects of pesticide production wastewater under direct and indirect discharge modes

Environmental Sciences Europe, Journal Year: 2025, Volume and Issue: 37(1)

Published: April 23, 2025

Language: Английский

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Organophosphorus Pesticides Management Strategies: Prohibition and Restriction Multi-Category Multi-Class Models, Environmental Transformation Risks, and Special Attention List

Toxics, Journal Year: 2024, Volume and Issue: 13(1), P. 16 - 16

Published: Dec. 26, 2024

Organophosphorus pesticides (OPs) have become one of the most widely used in Chinese agriculture; however, methods to identify potential restrictions on OPs molecules are lacking. Therefore, this study retrieved restriction list and constructed eight multi-class, multi-category machine learning models for restrictions. Among these, random forest (RF) model demonstrated excellent predictive performance, as it was successfully validated applied. Potential environmental transformation products were obtained using EAWAG-BBD software, while toxicity indicators parent their predicted with ADMETlab 3.0 software. This found that unrestricted OPs, such phorate, parathion, chlorpyrifos, exhibited a high probability toxicity. Additionally, posed similar comprehensive risks compounds. A special attention created based products, standard deviation classification. Phorate parathion identified requiring attention. paper aims provide an effective method identifying levels propose evaluation system comprehensively considers health risk, thereby supporting improvement optimization management usage strategies OPs.

Language: Английский

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Removal of nitrothal-isopropyl and endosulfan from wastewater using modified coffee grounds by diethylenetriamine nanocomposites: Adsorption kinetics and DFT simulation study

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Water pollution containing high concentrations of organic pollutants such as nitrothal-isopropyl and endosulfan is a serious concern in the environment because both are implicated eutrophication receiving water. Nitrothal-isopropyl two main that cause water eutrophication. In this study, MCG-DETA nanocomposites used strong bio-adsorbent for removal from wastewater were investigated. The aim study to recycle adsorption compounds. optimum capacity 35.74 mg/L 19.21 mg/L, respectively. For adsorption, Freund isotherm model was suitable. Modification coffee grounds by diethylenetriamine can serve potential low-cost adsorbent remove wastewater. According DFT calculations, electrostatic interactions between with modified verified. highest possibility attraction -COOH -NO₂ nitrothal-isopropyl. addition, due COOH NH₂ sulfonyl halide endosulfan. This effort enhanced our thoughtfulness elimination mentioned using experimentally theoretically.

Language: Английский

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Treatment wetlands in Iran: A review

Ecological Engineering, Journal Year: 2024, Volume and Issue: 212, P. 107494 - 107494

Published: Dec. 16, 2024

Language: Английский

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