Ginseng polysaccharides ameliorate abnormal lipid metabolism caused by acute alcoholic liver injury by promoting autophagy DOI Creative Commons
Xin Qi,

Xihan Sun,

Muyao Wang

et al.

Food Frontiers, Journal Year: 2023, Volume and Issue: 4(1), P. 394 - 406

Published: Jan. 13, 2023

Abstract The study aimed to examine the effect of ginseng polysaccharide (GP) on acute alcoholic liver injury (AALI) and determine its underlying molecular mechanism. GP's in vitro vivo hepatoprotective effects were evaluated using LO2 cells alcohol‐induced C57BL/6 male mice. Cell Counting Kit‐8, immunofluorescence, hematoxylin‐eosin, immunohistochemistry, Western blot (WB) used detect lipid metabolism autophagy levels liver. It was mainly composed glucose, galactose, arabinose a molar ratio 12.9:1.6:1.0. Experiments demonstrated that administration GP significantly increased increase cell viability. In addition, it can inhibit lipogenesis, enhance lipolysis, stimulate autophagy. mice, also inhibited hepatic histological lesions, prevented alanine aminotransferase aspartate elevation, improved abnormal metabolism, boosted hepatocyte analysis mechanisms revealed promotes expression proteins AALI thereby alleviating it.

Language: Английский

AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages DOI Creative Commons
Liangjun Xia, Chunli Zhang, Nianyin Lv

et al.

Theranostics, Journal Year: 2022, Volume and Issue: 12(6), P. 2928 - 2947

Published: Jan. 1, 2022

Rationale: Aberrant activation of macrophages with mitochondria dismiss was proved to be associated pathogenesis ALI (acute lung injury). Exosomes from adipose-derived mesenchymal stem cells (AdMSC-Exos) have been distinguished by their low immunogenicity, lack tumorigenicity, and high clinical safety, but role in treating the mechanism involved need defined. In this study, we sought investigate whether mitochondrial donation AdMSC-Exos provides profound protection against LPS-induced mice, accompanied improvement macrophage function. Methods: C57BL/6 mice were orotracheally instilled LPS (1 mg/kg). administered via tail vein 4 h after inhalation. Flow cytometry, H&E, Quantitative Real-Time PCR, immunofluorescence (IF), confocal microscopy imaging conducted tissue inflammation And further observe transfer exosomes effect on function MH-S through vitro experiments. Results: can cell-derived components alveolar a dose-dependent manner. Likely complementing damaged mitochondria, exhibited ability elevate level mtDNA, membrane potential (MMP), OXPHOS activity ATP generation, while reliving mROS stress LPS-challenged macrophages. Restoring integrity treatment enabled shifting anti-inflammatory phenotype, as featured down-regulation IL-1β, TNF-α iNOS secretion increase production cytokines IL-10 Arg-1. As depleted using clodronate liposomes, protective for largely abrogated. Conclusions: effectively donate component improved oxidative phosphorylation level, leading resumption metabolic immune homeostasis airway mitigating inflammatory pathology.

Language: Английский

Citations

192
Ginseng-derived nanoparticles alleviate inflammatory bowel disease via the TLR4/MAPK and p62/Nrf2/Keap1 pathways DOI Creative Commons
Song Yang, Wenjing Li, Xueyuan Bai

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 1, 2024

Abstract Inflammatory bowel disease (IBD) is closely linked to the homeostasis of intestinal environment, and exosomes can be used treat IBD due their high biocompatibility ability effectively absorbed by tract. However, Ginseng-derived nanoparticles (GDNPs) have not been studied in this context mechanism action remains unclear. Here, we investigated GDNPs mediate intercellular communication a complex inflammatory microenvironment order IBD. We found that scavenge reactive oxygen species from immune cells epithelial cells, inhibit expression pro-inflammatory factors, promote proliferation differentiation stem as well enhancing diversity flora. significantly stabilise barrier thereby promoting tissue repair. Overall, proved ameliorate inflammation oxidative stress vivo vitro, acting on TLR4/MAPK p62/Keap1/Nrf2 pathways, exerting an anti-inflammatory antioxidant effect. mitigated mice reducing factors improving environment. This study offers new evidence potential therapeutic effects IBD, providing conceptual ground for alternative strategy. Graphical

Language: Английский

Citations

20
Application of fermented Chinese herbal medicines in food and medicine field: From an antioxidant perspective DOI
Yuzhu Zhang, Jing Zhang,

Jingwen Yan

et al.

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 148, P. 104410 - 104410

Published: April 7, 2024

Language: Английский

Citations

19
Pharmacological effects of ginseng and ginsenosides on intestinal inflammation and the immune system DOI Creative Commons

Linxian Zhao,

Tongbo Zhang,

Kai Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 18, 2024

Intestinal inflammatory imbalance and immune dysfunction may lead to a spectrum of intestinal diseases, such as bowel disease (IBD) gastrointestinal tumors. As the king herbs, ginseng has exerted wide range pharmacological effects in various diseases. Especially, it been shown that ginsenosides have strong immunomodulatory anti-inflammatory abilities system. In this review, we summarized how extracts influence inflammation function, including regulating balance, modulating expression mediators cytokines, promoting mucosal wound healing, preventing colitis-associated colorectal cancer, recovering gut microbiota metabolism imbalance, alleviating antibiotic-induced diarrhea, relieving symptoms irritable syndrome. addition, specific experimental methods key control mechanisms are also briefly described.

Language: Английский

Citations

18
Recent advances in adipose-derived mesenchymal stem cell-derived exosomes for regulating macrophage polarization DOI Creative Commons
Zhihui Dong, Yingli Fu, Zhongming Cai

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 3, 2025

Adipose-derived mesenchymal stem cells (ADSCs) exhibit superior immunomodulatory properties and have broad therapeutic applications. They induce macrophage M2 polarization for anti-inflammatory responses. Exosomes derived from ADSCs (ADSC-EXOs) biological functions similar to those of but can circumvent the limitations associated with cellular injection therapies. Potent substances contained in exosomes include glycoprotein MFGE8, cytokines such as prostaglandin E2, IL-6, IGF, well non-coding nucleotides (miR-451a, miR-23, miR-30d-5p, let-7, lncRNA DLEU2, circRps5, Circ-Ptpn4, mmu_ circ_0001359). The these provide new perspectives approaches graft inflammation, bone healing, acute lung injury, kidney stones, myocardial infarction, diabetes-related diseases. This review summarizes contents ADSC-EXOs, outlines their characteristics phenotypes, emphasizes impact on contribution immune-related

Language: Английский

Citations

3
Mitigative effects of didymin against cadmium-induced renal injury via regulating Nrf-2/Keap-1, apoptosis, inflammation and oxidative stress DOI

Ali Hamza,

Sayda Snober Fatima Zadi,

Muhammad Zaid Salar

et al.

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: 88, P. 127597 - 127597

Published: Jan. 14, 2025

Language: Английский

Citations

2
Ginsenoside Rg1 alleviates ANIT-induced cholestatic liver injury by inhibiting hepatic inflammation and oxidative stress via SIRT1 activation DOI Creative Commons

Qianyan Gao,

Guodong Li, Yue Zu

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 319, P. 117089 - 117089

Published: Aug. 26, 2023

Ginseng (Panax ginseng C. A. Mey) is a common traditional Chinese medicine used for anti-inflammation, treating colitis, type 2 diabetes, diarrhea, and recovering hepatobiliary function. Ginsenosides, the main active components isolated from ginseng, possess liver gallbladder diseases therapeutic potential. Cholestatic injury (CLI) disease induced by intrahepatic accumulation of toxic bile acids currently lacks clinically effective drugs. Our previous study found that ginsenosides alleviated CLI activating sirtuin 1 (SIRT1), but ingredients underlying mechanism have not been clarified. This aimed to identify an ingredient with most significant activation effect on SIRT1 five major monomer saponins ginsenosides: Rb1, Rd, Rg1, 20s-Rg3, Rc further explore its protective effects CLI, elaborate mechanism. Discovery Studio 3.0 was conduct molecular docking between SIRT1, detect influence activity in vitro. Finally, it determined Rg1 had stimulative hepatoprotective explored vivo. Wild-type mice were intragastrically α-naphthylisothiocyanate (ANIT) establish experimental model cholestasis intervention, then related indexes detected. In addition, Liver-specific gene knockout (SIRT1-/-) administered ANIT and/or investigate action Rg1. The results vitro experiments showed all ginsenoside monomers could bind site promote HepG2 cells. Among them, exhibited stimulation cholestasis. Besides, ameliorate ANIT-induced inflammation oxidative stress Therefore, we investigated CLI. Results reversed increase biochemical parameters, improved pathological injury, decreased lipid accumulation, reactive oxygen species pro-inflammatory factor levels. Mechanistically, expression, followed promoted Nrf2 suppressed NF-κB. Interestingly, blocked SIRT1-/- mice. mitigated via upregulating our suggested candidate compound

Language: Английский

Citations

30
Recent Advances in Cellular Signaling Interplay between Redox Metabolism and Autophagy Modulation in Cancer: An Overview of Molecular Mechanisms and Therapeutic Interventions DOI Creative Commons
Md. Ataur Rahman, Kazi Rejvee Ahmed,

Farzana Haque

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 428 - 428

Published: Feb. 9, 2023

Autophagy is a fundamental homeostatic process in which certain cellular components are ingested by double-membrane autophagosomes and then degraded to create energy or maintain homeostasis survival. It typically observed nutrient-deprived cells as survival mechanism. However, it has also been identified crucial maintaining disease progression. Normal metabolism produces reactive oxygen (ROS) nitrogen species at low levels. increased production causes oxidative stress, can lead diabetes, cardiovascular diseases, neurological disorders, cancer. was recently shown that redox equilibrium via autophagy critical for responses stress. little understood about the molecular cancer processes connect control of autophagy. In cells, oncogenic mutations, carcinogens, metabolic reprogramming cause ROS generation Recent studies have suggested activates pathways promote development metastasis. Moreover, relationship between programming involved malignant phenotype. Currently, while signaling events governing how affects cascades well understood, very known related this review, we focus on current knowledge modulation role further stress progression regulation. Therefore, review focuses understanding oxidation/reduction fine-tune help understand govern cancer, either leading cell death strategies

Language: Английский

Citations

25
Ginseng polysaccharide reduces autoimmune hepatitis inflammatory response by inhibiting PI3K/AKT and TLRs/NF-κB signaling pathways DOI
Xin Qi, Xintong Lu,

Yudi Han

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 116, P. 154859 - 154859

Published: May 4, 2023

Language: Английский

Citations

25
Evolution of reactive oxygen species cellular targets for plant development DOI
Vijay Pratap Singh,

Saumya Jaiswal,

Yuanyuan Wang

et al.

Trends in Plant Science, Journal Year: 2024, Volume and Issue: 29(8), P. 865 - 877

Published: March 21, 2024

Language: Английский

Citations

17