Ginseng polysaccharides ameliorate abnormal lipid metabolism caused by acute alcoholic liver injury by promoting autophagy DOI Creative Commons
Xin Qi,

Xihan Sun,

Muyao Wang

et al.

Food Frontiers, Journal Year: 2023, Volume and Issue: 4(1), P. 394 - 406

Published: Jan. 13, 2023

Abstract The study aimed to examine the effect of ginseng polysaccharide (GP) on acute alcoholic liver injury (AALI) and determine its underlying molecular mechanism. GP's in vitro vivo hepatoprotective effects were evaluated using LO2 cells alcohol‐induced C57BL/6 male mice. Cell Counting Kit‐8, immunofluorescence, hematoxylin‐eosin, immunohistochemistry, Western blot (WB) used detect lipid metabolism autophagy levels liver. It was mainly composed glucose, galactose, arabinose a molar ratio 12.9:1.6:1.0. Experiments demonstrated that administration GP significantly increased increase cell viability. In addition, it can inhibit lipogenesis, enhance lipolysis, stimulate autophagy. mice, also inhibited hepatic histological lesions, prevented alanine aminotransferase aspartate elevation, improved abnormal metabolism, boosted hepatocyte analysis mechanisms revealed promotes expression proteins AALI thereby alleviating it.

Language: Английский

Traditional Chinese medicine in regulating macrophage polarization in immune response of inflammatory diseases DOI
Shiyu Chen,

Jiuseng Zeng,

Rui Li

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 325, P. 117838 - 117838

Published: Feb. 3, 2024

Language: Английский

Citations

16
Purple Sweet Potato Polysaccharide Exerting an Anti-inflammatory Effect via a TLR-Mediated Pathway by Regulating Polarization and Inhibiting the Inflammasome Activation DOI

Dongxue Song,

Junbo Niu,

Ziyi Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(4), P. 2165 - 2177

Published: Jan. 17, 2024

Purple sweet potato polysaccharide (PSPP-1) is a novel glucan; this study aimed to examine the anti-inflammatory effect of PSPP-1 and elucidate its potential mechanisms. Lipopolysaccharide (LPS)-induced RAW264.7 was used as model inflammation, cell viability, levels nitric oxide (NO), reactive oxygen species (ROS), calcium ion (Ca2+) were analyzed. ELISA qPCR assess productions mRNA expression cytokines, Western blotting protein expressions in TLR-mediated pathway, macrophage polarization, inflammasome activation. The results demonstrated inhibited proliferation markedly decreased NO, ROS, Ca2+ levels. Moreover, suppressed secretions pro-inflammatory cytokines increased those cytokines. Furthermore, could exert effects through different pathways mediated by both TLR2 TLR4, which modulated essential proteins myeloid differentiation factor 88 (MyD88)-dependent toll/IL-1 receptor domain-containing adaptor-inducing interferon-β (TRIF)-dependent signaling pathways. even regulated polarization M1/M2 macrophages nucleotide oligomerization domain-like 3 (NLRP3) These findings indicate that can suppress LPS-induced inflammation via multiple may be agent for therapeutic inflammation-related pathophysiological processes disorders.

Language: Английский

Citations

12
Transcriptome and chromatin accessibility landscape of ovarian development at different egg-laying stages in taihe black-bone silky fowls DOI Creative Commons
Jingyi Zhang,

Yong Cui,

Jiming Ruan

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(3), P. 104864 - 104864

Published: Feb. 7, 2025

Language: Английский

Citations

1
Zn2+-Driven Metformin conjugated with siRNA attenuates osteoarthritis progression by inhibiting NF-κB signaling and activating autophagy DOI
Haoqiang He, Chuanshu Huang, Hongjun Huang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123210 - 123210

Published: Feb. 24, 2025

Language: Английский

Citations

1
Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review DOI Creative Commons
Lucas Fornari Laurindo,

Mariana Canevari de Maio,

Giulia Minniti

et al.

Metabolites, Journal Year: 2023, Volume and Issue: 13(2), P. 243 - 243

Published: Feb. 7, 2023

Inflammatory bowel diseases (IBDs) are related to nuclear factor erythroid 2-related 2 (Nrf2) dysregulation. In vitro and in vivo studies using phytocompounds as modulators of the Nrf2 signaling IBD have already been published. However, no existing review emphasizes whole scenario for potential plants regulators models colitis-associated colorectal carcinogenesis. For these reasons, this study aimed build a that could fill void. The PubMed, EMBASE, COCHRANE, Google Scholar databases were searched. literature showed medicinal phytochemicals regulated on IBD-associated cancer by amplifying expression Nrf2-mediated phase II detoxifying enzymes diminishing NF-κB-related inflammation. These effects improve environment, mucosal barrier, colon, crypt disruption, reduce ulceration microbial translocation, consequently, disease activity index (DAI). Moreover, modulation can regulate various genes involved cellular redox, protein degradation, DNA repair, xenobiotic metabolism, apoptosis, contributing prevention cancer.

Language: Английский

Citations

21
Genes and Regulatory Mechanisms for Ginsenoside Biosynthesis DOI Open Access
Padmanaban Mohanan, Tae‐Jin Yang, Young Hun Song

et al.

Journal of Plant Biology, Journal Year: 2023, Volume and Issue: 66(1), P. 87 - 97

Published: Jan. 21, 2023

Language: Английский

Citations

20
Hepatoprotective effects of astragalin against polystyrene microplastics induced hepatic damage in male albino rats by modulating Nrf-2/Keap-1 pathway DOI Creative Commons

Ali Hamza,

Muhammad Umar Ijaz, Nazia Ehsan

et al.

Journal of Functional Foods, Journal Year: 2023, Volume and Issue: 108, P. 105771 - 105771

Published: Sept. 1, 2023

The current study was designed to determine the curative potential of astragalin (AST) against polystyrene microplastics (PS-MPs) induced hepatic toxicity in rats. PS-MPs exposure decreased expression Nrf-2 and anti-oxidant enzymes, while increasing Keap-1 expression. activities glutathione-S-transferase, catalase, glutathione, glutathione peroxidase, superoxide dismutase, reductase heme oxygenase-1 were decreased, besides levels malondialdehyde reactive oxygen species also increased following PS-MPs. intoxication elevated aspartate aminotransferase, alanine transaminase, alkaline phosphatase levels, as well cyclooxygenase-2 activity, interleukin-6, interleukin-1 beta, nuclear factor-kappa B tumor necrosis factor-alpha escalated. Furthermore, Bcl-2 down-regulated, Bax Caspase-3 expressions upregulated exposure. Histopathological assessment revealed substantial liver damages treated However, AST supplementation substantially recovered PS-MPs-induced histological anomalies. Therefore, can be used a agent treat PS-MPs-prompted hepatotoxicity due its anti-apoptotic, anti-inflammatory potentials.

Language: Английский

Citations

19
Research progress of the mechanisms and applications of ginsenosides in promoting bone formation DOI
Ze Li, Yanan Li, Chaoran Liu

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155604 - 155604

Published: April 8, 2024

Language: Английский

Citations

8
Revealing the potential bioactive components and mechanism of Qianhua Gout Capsules in the treatment of gouty arthritis through network pharmacology, molecular docking and pharmacodynamic study strategies DOI Creative Commons
Gelin Xiang,

Luyin Yang,

Jing Qin

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(10), P. e30983 - e30983

Published: May 1, 2024

Recent clinical studies have confirmed the effectiveness of Qianhua Gout Capsules (QGC) in treatment gouty arthritis (GA). However, specific regulatory targets and mechanisms action QGC are still unclear. To address this gap, we utilized network pharmacology, molecular docking, pharmacodynamic approaches to investigate bioactive components associated GA. By employing UPLC-Q Exactive-MS, identified compounds present QGC, with active ingredients defined as those oral bioavailability ≥30 % drug similarity ≥0.18. Subsequently, these were determined using TCMSP database, while GA-related from DisGeNET, GeneCards, TTD, OMIM, DrugBank databases. Further analysis including PPI analysis, GO KEGG pathway enrichment was conducted on targets. Validation predicted results performed a GA rat model, evaluating pathological changes, inflammatory markers, protein expression. Our revealed total 130 components, 44 16 potential shared targets, GO-enriched terms, 47 signaling pathways related disease Key included quercetin, kaempferol, β-sitosterol, luteolin, wogonin. The highlighted five (PPARG, IL-6, MMP-9, IL-1β, CXCL-8) highest connectivity, predominantly enriched IL-17 pathway. Molecular docking experiments demonstrated strong binding CXCL8, MMP9, PPARG top compounds. Furthermore, animal efficacy treating rats, showing reductions TNF-α, MDA levels, increases SOD levels serum. In synovial tissues, upregulated CXCL8 expression, downregulating IL-6 conclusion, study applied pharmacology approach uncover composition predict its pharmacological interactions, demonstrate

Language: Английский

Citations

8
Autophagy: A potential target for natural products in the treatment of ulcerative colitis DOI Open Access
Wei Zhang, Menglong Zou, Jia Fu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116891 - 116891

Published: June 12, 2024

Ulcerative colitis (UC) is a chronic inflammatory bowel disease primarily affecting the mucosa of colon and rectum. UC characterized by recurrent episodes, often necessitating lifelong medication use, imposing significant burden on patients. Current conventional advanced treatments for have disadvantages insufficient efficiency, susceptibility to drug resistance, notable adverse effects. Therefore, developing effective safe drugs has become an urgent need. Autophagy intracellular degradation process that plays important role in intestinal homeostasis. Emerging evidence suggests aberrant autophagy involved development UC, modulating can effectively alleviate experimental colitis. A growing number studies established interplay with endoplasmic reticulum stress, gut microbiota, apoptosis, NLRP3 inflammasome, all which contribute pathogenesis UC. In addition, variety epithelial cells, including absorptive goblet Paneth as well other cell types like neutrophils, antigen-presenting stem cells gut, mediate through autophagy. To date, many found natural products hold potential exert therapeutic effects regulating This review focuses possible pharmacological mechanisms target recent years, aiming provide basis new development.

Language: Английский

Citations

8