Evaluation of histopathological and healing potentials of the full-thickness cutaneous wound for a topical ointment formulation containing extract of bark Quercus aegilops in mice DOI Creative Commons
Thamer Jaddoa Shihab,

Ahmad A. Sultan,

Ali Ghazi Atiyah

et al.

˜Al-œmağallaẗ al-ʻirāqiyyaẗ li-l-ʻulūm al-bayṭariyyaẗ/Iraqi journal of veterinary sciences, Journal Year: 2023, Volume and Issue: 37(Supplement I-IV), P. 121 - 128

Published: Dec. 1, 2023

Cutaneous wounds are significant problems that can be treated with traditional herbal supplements. This study evaluated the wound healing potential of Quercus aegilops barks extract formulations on excision wounds. BQAE extractions were acquired and employed to make two distinct formulas, namely, 10 20% extract. These applied topically once daily for 12 days check out their capacity heal in a mice model repair. At 0,3,6,9 days, sizes areas observed. Hematoxylin Eosin staining used skin tissue samples histopathological evaluation. The ointments found stable skin-safe. Comparing contraction area positive (standard reference Povidone-iodine) negative controls, both caused substantial (P<0.05) reduction these parameters (wound area). A increase levels Reduced glutathione, Superoxide dismutase, Catalase, as decrease Malondialdehyde was observed groups when compared groups. studies biopsy day increased collagen formation, number neovascularization, reformation sebaceous glands, full thickness epithelization epidermal layer soon standard Povidone- iodine 10% (positive control) control Thus, vitro (physical properties ointment) vivo scientifically validated wound-healing activity (BQAE), which explained production antioxidant activity, thereby supporting claims.

Language: Английский

Evaluation of histopathological and healing potentials of the full-thickness cutaneous wound for a topical ointment formulation containing extract of bark Quercus aegilops in mice DOI Creative Commons
Thamer Jaddoa Shihab,

Ahmad A. Sultan,

Ali Ghazi Atiyah

et al.

˜Al-œmağallaẗ al-ʻirāqiyyaẗ li-l-ʻulūm al-bayṭariyyaẗ/Iraqi journal of veterinary sciences, Journal Year: 2023, Volume and Issue: 37(Supplement I-IV), P. 121 - 128

Published: Dec. 1, 2023

Cutaneous wounds are significant problems that can be treated with traditional herbal supplements. This study evaluated the wound healing potential of Quercus aegilops barks extract formulations on excision wounds. BQAE extractions were acquired and employed to make two distinct formulas, namely, 10 20% extract. These applied topically once daily for 12 days check out their capacity heal in a mice model repair. At 0,3,6,9 days, sizes areas observed. Hematoxylin Eosin staining used skin tissue samples histopathological evaluation. The ointments found stable skin-safe. Comparing contraction area positive (standard reference Povidone-iodine) negative controls, both caused substantial (P<0.05) reduction these parameters (wound area). A increase levels Reduced glutathione, Superoxide dismutase, Catalase, as decrease Malondialdehyde was observed groups when compared groups. studies biopsy day increased collagen formation, number neovascularization, reformation sebaceous glands, full thickness epithelization epidermal layer soon standard Povidone- iodine 10% (positive control) control Thus, vitro (physical properties ointment) vivo scientifically validated wound-healing activity (BQAE), which explained production antioxidant activity, thereby supporting claims.

Language: Английский

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