Heliyon, Journal Year: 2023, Volume and Issue: 10(1), P. e23581 - e23581
Published: Dec. 11, 2023
Sinomenine (SN) is a well-documented unique plant alkaloid extracted from many herbal medicines. The present study evaluates the wound healing potentials of SN on dorsal neck injury in rats. A uniform cut was created Sprague Dawley rats (24) which were arbitrarily aligned into 4 groups receiving two daily topical treatments for 14 days as follows: A, had gum acacia; B, addressed with intrasite gel; C and D, 30 60 mg/ml SN, respectively. acute toxicity trial revealed absence any toxic signs after weeks ingestion 300 mg/kg SN. SN-treated showed smaller areas higher closure percentages compared to vehicle 5, 10, 15 skin excision. Histological evaluation recovered tissues increased collagen deposition, fibroblast content, decreased inflammatory cells granulated SN-addressed rats, statistically different that acacia-treated treatment caused positive augmentation Transforming Growth Factor Beta 1 (angiogenetic factor) tissues, denoting conversion rate myofibroblast (angiogenesis) results faster action. Increased antioxidant enzymes (SOD CAT), well MDA contents suggest aid recovery. Wound tissue homogenates hydroxyproline amino acid (collagen content) values than suppressed production pro-inflammatory cytokines anti-inflammatory serum wounded outcomes viable pharmaceutical agent evidenced by its modulation antioxidant, immunohistochemically proteins, hydroxyproline, cytokines.
Language: Английский