Exploring the Protective Mechanisms of Chayote (Sechium edule) Juice in Mitigating Streptozotocin‐Induced Pancreatic Dysfunction DOI Creative Commons

Yoon-A Jeon,

Premkumar Natraj, Soo‐Heui Paik

et al.

eFood, Journal Year: 2024, Volume and Issue: 6(1)

Published: Dec. 29, 2024

ABSTRACT Chayote ( Sechium edule ) has been traditionally used in Mexico to manage diabetes, owing its hypoglycemic, anti‐oxidant, and anti‐inflammatory properties. However, the specific effects mechanisms of chayote juice (SEJ) preventing pancreatic dysfunction remain underexplored. This study investigated protective underlying SEJ multiple low‐dose streptozotocin (MLD‐STZ)‐induced diabetic mouse model H 2 O ‐treated insulinoma cell line (MIN‐6). C57BL/6 mice were administered MLD‐STZ induce treated with SEJ. Diabetic parameters, islet morphology, protein expressions evaluated. MIN‐6 cells assess SEJ's at cellular level. Molecular docking studies performed elucidate interactions between phenolic compounds key proteins involved oxidative stress. significantly preserved structure insulin levels, reducing blood glucose levels. Mechanistically, suppressed expression apoptosis markers (caspase‐3, PARP, BAX) inflammatory (NF‐κB, iNOS, NLRP3) pancreas MIN6 cells, indicating protection β‐cells. Furthermore, upregulates endogenous anti‐oxidant (Nrf‐2, HO‐1), which are essential for mitigating stress‐induced stress diabetes circumstances. indicated that vicenin‐2 exhibit strong binding affinities KEAP‐1, Nrf‐2, HO‐1 proteins. demonstrates substantial through anti‐apoptotic, actions. These findings suggest could be developed as a functional food management.

Language: Английский

New insight into oxidative stress and inflammatory responses to kidney stones: Potential therapeutic strategies with natural active ingredients DOI Open Access
Yue Sun,

Hongmei Sun,

Zhengze Zhang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117333 - 117333

Published: Sept. 8, 2024

Language: Английский

Citations

11
An In-Silico Identification of Potential Flavonoids against Kidney Fibrosis Targeting TGFβR-1 DOI Creative Commons
MD. Hasanur Rahman, Partha Biswas, Dipta Dey

et al.

Life, Journal Year: 2022, Volume and Issue: 12(11), P. 1764 - 1764

Published: Nov. 2, 2022

Fibrosis is a hallmark of progressive kidney diseases. The overexpression profibrotic cytokine, namely transforming growth factor β (TGF-β) due to excessive inflammation and tissue damage, induces fibrosis. inhibition TGF-β signaling markedly limited in experimental disease models. Targeting signaling, therefore, offers prospective strategy for the management Presently, marketed drugs have numerous side effects, but plant-derived compounds are relatively safer more cost-effective. In this study, TGFβR-1 was targeted identify lead among flavonoids using various computational approaches, such as ADME/T (absorption, distribution, metabolism, excretion/toxicity) analysis, molecular docking, dynamics simulation. screening identified total 31 with drug-like properties compounds, 5 showed higher binding affinity TGFβR-1, Epicatechin, Fisetin, Luteolin ranking at top three (-13.58, -13.17, -10.50 kcal/mol, respectively), which comparable control drug linagliptin (-9.074 kcal/mol). also exhibited outstanding protein-ligand interactions. dynamic simulations revealed stable interaction these site TGFβR-1. These findings indicate that flavonoids, particularly Luteolin, may compete ligand-binding suggesting can be further evaluated development potential therapeutics against Further,

Language: Английский

Citations

22
Evidence for the efficacy of anti-inflammatory plants used in Brazilian traditional medicine with ethnopharmacological relevance DOI
Rafael Christian de Matos,

Ana Flávia Alvarenga Bitencourt,

Alexsandro Davi Mantovani de Oliveira

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 329, P. 118137 - 118137

Published: April 2, 2024

Language: Английский

Citations

4
Ethnopharmacological basis for traditional use of Tradescantia spathaceae as Nephroprotective agent via in vitro, in vivo and Molecular Docking Techniques DOI
Rabia Naz, Fatima Saqib

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119451 - 119451

Published: Feb. 1, 2025

Language: Английский

Citations

0
Nephroprotective Plant Species Used in Brazilian Traditional Medicine for Renal Diseases: Ethnomedical, Pharmacological, and Chemical Insights DOI Creative Commons

Rodrigo Carlesso,

Yasmin Louise Ramos Cappellari,

Daiana Daniele Boeff

et al.

Plants, Journal Year: 2025, Volume and Issue: 14(5), P. 648 - 648

Published: Feb. 20, 2025

The prevalence of kidney-related diseases has been increasing and emerged globally as a leading cause mortality, especially in developing countries where they are considered neglected public health problem. Renal commonly progressive may irreversible loss organ function, eventually necessitating renal replacement therapy. Although different pharmaceuticals for the treatment these pathologies, uncertain effectiveness presence adverse effects have generated growing need development novel nephroprotective compounds. Because many medicinal herbs typically used Brazilian folk medicine to prevent cure kidney ailments, ethnomedicine play promising strategic role identifying adding new potential molecules pharmacological arsenal. This review focuses on use plants secondary metabolites belonging classes treat diseases, associating screened plant extracts with bioactive components present each species. Flavonoids triterpenes notable that therapeutic potential. putative mechanisms related properties also discussed vitro vivo models, when available.

Language: Английский

Citations

0
Enhancing Health through Phenolic Compounds: A Comprehensive Review of Spices and Herbs Consumed in Cameroon Based on Global Research DOI Creative Commons
Fabrice Fabien Dongho Dongmo,

Adelaïde Mawamba Demasse,

Rébecca Madeleine Ebelle Etame

et al.

Applied Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 100837 - 100837

Published: March 1, 2025

Language: Английский

Citations

0
Educación contable para el desarrollo económico en Colombia: evolución y precisiones académicas DOI Creative Commons
Carolina Vargas Vanegas, Alexandra Vargas Staper

Revista Venezolana de Gerencia, Journal Year: 2025, Volume and Issue: 30(110), P. 865 - 880

Published: April 4, 2025

Esta investigación analiza la evolución académica e histórica de contaduría pública, destacando importancia en el desarrollo económico y su relevancia formación estudiantes frente a los retos globales actuales, lo cual resalta rol clave contabilidad al proporcionar información financiera precisa respaldando toma decisiones transparencia. Además, se subraya que integración prácticas contables modernas procesos educativos fomenta profesionales competitivos. El estudio adopta un enfoque cualitativo utilizando técnicas bibliométricas basadas análisis literatura científica bases datos como SCOPUS, WOS PubMed incorpora participación activa resultados, fortaleciendo sus competencias críticas analíticas. Los resultados evidencian avances significativos contable, mientras estudiantil Administración Empresas Contaduría Pública demuestra es una herramienta pedagógica eficaz; las implicaciones este trabajo subrayan alinear programas con desafíos para formar herramientas responder necesidades entorno constante cambio. La originalidad radica combinación bibliométrico realizan través ensayos argumentativos, ofreciendo innovador conecta educación contable demandas del contexto global.

Citations

0
Educación contable para el desarrollo económico en Colombia: evolución y precisiones académicas DOI Creative Commons
Carolina Vargas Vanegas, Alexandra Vargas Staper

Revista Venezolana de Gerencia, Journal Year: 2025, Volume and Issue: 30(110), P. 865 - 880

Published: April 4, 2025

Esta investigación analiza la evolución académica e histórica de contaduría pública, destacando importancia en el desarrollo económico y su relevancia formación estudiantes frente a los retos globales actuales, lo cual resalta rol clave contabilidad al proporcionar información financiera precisa respaldando toma decisiones transparencia. Además, se subraya que integración prácticas contables modernas procesos educativos fomenta profesionales competitivos. El estudio adopta un enfoque cualitativo utilizando técnicas bibliométricas basadas análisis literatura científica bases datos como SCOPUS, WOS PubMed incorpora participación activa resultados, fortaleciendo sus competencias críticas analíticas. Los resultados evidencian avances significativos contable, mientras estudiantil Administración Empresas Contaduría Pública demuestra es una herramienta pedagógica eficaz; las implicaciones este trabajo subrayan alinear programas con desafíos para formar herramientas responder necesidades entorno constante cambio. La originalidad radica combinación bibliométrico realizan través ensayos argumentativos, ofreciendo innovador conecta educación contable demandas del contexto global.

Citations

0
Mercuric Chloride Induced Nephrotoxicity: Ameliorative Effect of Carica papaya Leaves Confirmed by Histopathology, Immunohistochemistry, and Gene Expression Studies DOI Creative Commons
Yuvaraj Maria Francis,

Balaji Karunakaran,

Fauzia Ashfaq

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(24), P. 21696 - 21708

Published: June 5, 2023

The present study analyzes the efficacy of ethanolic extract C. papaya leaves (ECP) against HgCl2-induced nephrotoxicity. effects on biochemical and percentage body organ weight nephrotoxicity in female Wistar rats were studied. divided into five groups with six animals each group: control, HgCl2 (2.5 mg/kg b.w.), N-acetylcysteine (NAC 180 mg/kg) + HgCl2, ECP (300 b.w.) (600 groups. After 28 days study, sacrificed 29th day to harvest blood kidneys for further analysis. effect was analyzed by immunohistochemistry (NGAL) real-time PCR (KIM-1 NGAL mRNA) results revealed that group showed prominent damage proximal tubules glomerulus nephrons enormous expression KIM-1 compared control group. simultaneous pretreatment NAC (180 300 reduced renal gene PCR. This attests nephroprotective toxicity.

Language: Английский

Citations

7
A U.S. Pharmacopeia (USP) overview of Pan American botanicals used in dietary supplements and herbal medicines DOI Creative Commons

Roy Upton,

Ignacio Agudelo,

Yadira Cabrera

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 30, 2024

The United States Pharmacopeial Convention (USP) is a nonprofit, scientific, standard-setting organization, and world leader in establishing quality, purity, testing standards for medicines, foods, dietary supplements. USP quality are used more than 140 countries legally recognized by 40 countries. Currently, there renewed interest herbal medicines globally, health policies being implemented worldwide the use of complementary traditional medicine. In response, has developed robust body monographs that can be to guide industry regulators ensuring safety botanical ingredients supplements medicines. Throughout Pan American regions, strong tradition using botanicals as and, other growing desire This underscores need public ensure reduce flow substandard adulterated products, safety. April 2022, launched America Botanical Dietary Supplements Herbal Medicines Expert Panel, with experts representing 12 different Panel's work focuses on developing control most important respective countries, also global importance. article provides an overview state regions focus regulatory status development national research initiatives, related agriculture conservation sustainability, among topics.

Language: Английский

Citations

2