Identification of the natural chalcone glycoside hydroxysafflor yellow A as a suppressor of P53 overactivation‐associated hematopoietic defects DOI Creative Commons
Jing Chen, Can Ren, Chong Yao

et al.

MedComm, Journal Year: 2023, Volume and Issue: 4(5)

Published: Aug. 24, 2023

Abstract Enhanced P53 signaling may lead to hematopoietic disorders, yet an effective therapeutic strategy is still lacking. Our study, along with previous research, suggests that overactivation and defects are major consequences of zinc deficiency. However, the relationship between these two pathological processes remains unclear. In this we observed a severe reduction in number stem cells (HSCs) multi‐lineage progenitor zebrafish treated chelator N , ′, ′‐tetrakis(2‐pyridylmethyl)ethylenediamine showed indispensable role process. Next, took advantage HSCs‐labeled transgenic conducted highly efficient phenotypic screening for small molecules against P53‐dependent disorders. Hydroxysafflor yellow A (HSYA), natural chalcone glycoside, exhibited potent protection failure zinc‐deficient strongly inhibited pathway. We confirmed protective effect HSYA mice bone marrow nucleated cells, which significant suppression oxidative stress. Furthermore, hematopoietic‐protective activity was validated using model myelotoxicity induced by 5‐FU. summary, our work provides identifying agents reveals novel as promising compound rescuing disorders associated overactivation.

Language: Английский

Highly oxidized rearranged derivatives of quinochalcone C-glycosides from Carthamus tinctorius DOI
Hao Zhang,

Chen-Ping Duan,

Xiang Yuan

et al.

Phytochemistry, Journal Year: 2024, Volume and Issue: 222, P. 114094 - 114094

Published: April 9, 2024

Language: Английский

Citations

1
[Expression and significance of hypoxia-inducible factor 1α and Bcl-2/adenovirus E1B19kDa-interacting protein 3 in children with traumatic brain injury]. DOI
Lei Zhu, Xuecheng Wang, Yanyan Xu

et al.

PubMed, Journal Year: 2024, Volume and Issue: 26(4), P. 378 - 384

Published: April 15, 2024

To dynamically observe the changes in hypoxia-inducible factor 1α (HIF-1α) and Bcl-2/adenovirus E1B19kDa-interacting protein 3 (BNIP3) children with traumatic brain injury (TBI) evaluate their clinical value predicting severity prognosis of pediatric TBI.

Language: Английский

Citations

0
Identification of the natural chalcone glycoside hydroxysafflor yellow A as a suppressor of P53 overactivation‐associated hematopoietic defects DOI Creative Commons
Jing Chen, Can Ren, Chong Yao

et al.

MedComm, Journal Year: 2023, Volume and Issue: 4(5)

Published: Aug. 24, 2023

Abstract Enhanced P53 signaling may lead to hematopoietic disorders, yet an effective therapeutic strategy is still lacking. Our study, along with previous research, suggests that overactivation and defects are major consequences of zinc deficiency. However, the relationship between these two pathological processes remains unclear. In this we observed a severe reduction in number stem cells (HSCs) multi‐lineage progenitor zebrafish treated chelator N , ′, ′‐tetrakis(2‐pyridylmethyl)ethylenediamine showed indispensable role process. Next, took advantage HSCs‐labeled transgenic conducted highly efficient phenotypic screening for small molecules against P53‐dependent disorders. Hydroxysafflor yellow A (HSYA), natural chalcone glycoside, exhibited potent protection failure zinc‐deficient strongly inhibited pathway. We confirmed protective effect HSYA mice bone marrow nucleated cells, which significant suppression oxidative stress. Furthermore, hematopoietic‐protective activity was validated using model myelotoxicity induced by 5‐FU. summary, our work provides identifying agents reveals novel as promising compound rescuing disorders associated overactivation.

Language: Английский

Citations

1