Kluyveromyces marxianus supplementation ameliorates alcohol-induced liver injury associated with the modulation of gut microbiota in mice

Food & Function, Journal Year: 2023, Volume and Issue: 14(21), P. 9920 - 9935

Published: Jan. 1, 2023

Kluyveromyces marxianus may ameliorate alcoholic liver injury by restoring the gut barrier and dysbiosis, reducing LPS leakage, inhibiting hepatic oxidative stress inflammation in mice.

Language: Английский

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Near-infrared lipid droplets polarity fluorescent probe for early diagnosis of nonalcoholic fatty liver disease

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 318, P. 124479 - 124479

Published: May 19, 2024

Language: Английский

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Multifunctional lipid droplet probes for observing the polarity change of ferroptosis, inflammation, fatty liver and evaluating the efficacy of drugs

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1312, P. 342747 - 342747

Published: May 20, 2024

Language: Английский

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Treatment of Liver Fibrosis with Chinese Medicines and Extracts: A Review

Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

Hepatic fibrosis (HF), a global issue that develops gradually during the repeated repair process of chronic liver injury caused by various factors, can progress to irreversible cirrhosis and hepatocellular carcinoma. Currently, there are no approved chemical or biological drugs for treatment fibrosis. Modern medicine primarily focuses on addressing underlying causes HF is classified as an accumulative disease in Yellow Emperor's Internal Classic, which earliest most influential extant medical classic China. Thousands years experience have accumulated large number effective Chinese medicines. In recent years, studies anti-liver effects mainly focused curative extracts compounds. Studies shown prevention through demonstrate comprehensive pharmacological effect involves multiple pathways targets. Therefore, further in-depth research this field both promising necessary. However, it crucial expand clinical application studies, current TCM predominantly limited laboratory investigations. review, we summarized effects, targets related mechanisms 13 traditional medicines past five order provide information development drugs.

Language: Английский

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Comparative study on the anti-alcoholic liver disease efficiency of the ethanol- and water-soluble polysaccharides from Baijiu vinasses

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140087 - 140087

Published: Jan. 1, 2025

Language: Английский

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Multiomics combined analysis reveals protective effect of 7-O-α-L-rhamnopyranosyl-kaempferol-3-O-β-D-glucopyranoside on autoimmune hepatitis

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156460 - 156460

Published: Feb. 2, 2025

Language: Английский

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Astragalus Polysaccharide Regulates Epithelial-mesenchymal Transition in HepG2 Liver Cancer Cells by Inhibiting NLRP3 Inflammasome Activation

Pharmacognosy Magazine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Background Epithelial-mesenchymal transition (EMT) is crucial in liver cancer progression. Developing novel medicines to disrupt the progression of EMT might be a approach managing cancer. Purpose This study investigates protective role Astragalus polysaccharide (APS), bioactive compound derived from membranaceus, modulating HepG2 cells. Methods The effects APS on were evaluated by assessing cell viability, proliferation, invasion, migration, cycle, and apoptosis Furthermore, involvement NOD-like receptor protein 3 (NLRP3) inflammasome this process was explored. Results Results: treatment significantly inhibited migration cells while promoting cycle arrest apoptosis. Notably, reduced expression NLRP3 components, including NLRP3, apoptosis-associated speck-like protein, caspase-1, decreasing levels inflammatory cytokines. In addition, activator Nigericin dampened effect partially rescuing activity NLRP3. Specifically, promoted development exacerbated malignant transformation improved APS. Conclusion Our findings demonstrated function which inhibits activation protect results showed that targeting application appears viable tactic for preventing

Language: Английский

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Recent advances in the role of polysaccharides in liver diseases: a review

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 27, 2025

Liver diseases are a serious health problem worldwide, especially with sustained increase in the burden of it every year. However, drugs commonly used patients have limited efficacy and adverse reactions associated long-term use. Therefore, is urgent to find effective safe alternatives. Polysaccharides currently considered promising alternatives traditional because their extensive activity low toxicity. This review investigated studies on hepatoprotective polysaccharides over past 6 years, detailing effects, potential mechanisms, drug carrier applications. These findings suggest that prominent preventive therapeutic effects various liver such as drug-induced injury, alcoholic disease, hepatitis B, non-alcoholic fatty fibrosis, hepatocellular carcinoma. Its mechanism includes multiple aspects metabolic regulation, reduction oxidative stress inflammation, regulation gut microbiota. Furthermore, owing good physicochemical properties, been applied delivery systems for chemotherapy small molecule drugs. further research essential bioavailability, structure-activity relationship, more clinical evidence polysaccharides. Continued exploration will provide tremendous treatment diseases.

Language: Английский

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Research Progress on the Extraction, Structure Elucidation, Biological Activities, and Drug Carrier Applications of Polygonati Rhizom Polysaccharides

Journal of Food Biochemistry, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

As widely used in traditional Chinese medicine and nutritional food, Polygonati Rhizom is known for its diverse pharmacological properties, including hematopoiesis, immune enhancement, antitumor, anti‐inflammatory, antioxidant, antiaging, antiviral, hepatoprotection. polysaccharides (PRPs) are primary bioactive compounds that water‐soluble mainly comprise fructose (Fru), glucose (Glc), galactose (Gal), arabinose (Ara), rhamnose (Rha), fucose (Fuc), xylose (Xyl), glucuronic acid (GlcA), galacturonic (GalA). Meanwhile, different extraction methods, such as hot water ultrasonic extractions, can significantly affect the yield of PRPs, Additionally, PRPs were also reported to hold promising potential a drug carrier. Herein, extraction, structure elucidation, biological activities, carrier applications systematically summarized, providing reference further research development Rhizom.

Language: Английский

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Polysaccharides, saponins and flavonoids in Astragali Radix: a review of phytochemistry and pharmacology for future therapeutic applications

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

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