Qizhu anticancer prescription enhances immunosurveillance of liver cancer cells by regulating p21-dependent secretory phenotypes

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 333, P. 118400 - 118400

Published: May 31, 2024

Language: Английский

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Baicalin Mitigates Cardiac Hypertrophy and Fibrosis by Inhibiting the p85a Subunit of PI3K

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 232 - 232

Published: Jan. 19, 2025

Background: Heart failure (HF) is a serious public health concern. Baicalin one of the major active ingredients traditional Chinese herbal medicine, Huang Qin, which used to treat patients with chest pain or cardiac discomfort. However, underlying mechanism(s) cardioprotective effect baicalin are still not fully understood. Methods: Isoprenaline injection transverse aortic constriction-induced animal models and isoprenaline angiotensin 2 administration-induced cell heart were established. (15 mg/kg/day 25 mg/kg/day) was administered in vivo, 10 μM vitro. Potential pharmacological targets genes related identified via different databases, suggested that PI3K–Akt may be involved effects baicalin. Molecular docking carried out reveal on p85a. Results: We observed significant antihypertrophic antifibrotic both vivo The mean cross-sectional area cardiomyocytes recovered from 390 μm2 HF group 195 baicalin-treated group. fibrosis reduced 2.8-fold 1.62-fold displayed inhibition PI3K signaling pathway by binding five amino acid residues p85a regulatory subunit PI3K. combination treatment an inhibitor p110 demonstrated stronger effect. ejection fraction increased 54% 67% Conclusions: Our work as new ingredient able isoprenaline-induced dysfunction suggests target. These findings potential combined for support more clinical trials future.

Language: Английский

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Chinese Medicine for the Treatment of Liver Cirrhosis: The Mechanism of Cellular Autophagy

The American Journal of Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 25

Published: March 12, 2025

Liver cirrhosis is a critical stage in the progression of various chronic liver diseases, often leading to severe complications such as ascites, hepatic encephalopathy, and high mortality rate, it thus poses serious threat patient life. The activation stellate cells central driver disease progression. Cellular autophagy, lysosome-mediated degradation process, plays key role maintaining cellular function dynamic homeostasis. Research has shown that autophagy closely associated with proteins like LC3, Beclin-1, P62, mTOR, regulated through signaling pathways PI3K/Akt/mTOR, Ras/Raf/MEK/ERK, AMPK/mTOR. Additionally, relationship between apoptosis, well exosomes, been further demonstrated. While modern medicine made progress treating cirrhosis, still faces significant limitations. By contrast, numerous studies have demonstrated efficacy traditional Chinese preventing by regulating fewer adverse effects. herbal monomers formulations can modulate autophagy-related pathways, including AMPK/mTOR, influence LC3 Beclin-1. This modulation inhibits cell activation, reduces extracellular matrix deposition, exerts anticirrhotic Moreover, appears reduce reactions treatment lower risk recurrence. review explores mechanisms prevention medicine, offering new insights for development medicinal therapies their rational clinical application.

Language: Английский

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TJ0113-induced mitophagy in acute liver failure detected by Raman microspectroscopy

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103654 - 103654

Published: April 1, 2025

Language: Английский

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