Exploring antithrombotic mechanisms and effective constituents of Lagopsis supina using an integrated strategy based on network pharmacology, molecular docking, metabolomics, and experimental verification in rats

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 336, P. 118717 - 118717

Published: Aug. 23, 2024

Language: Английский

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Lagopsis supina ameliorates myocardial ischemia injury by regulating angiogenesis, thrombosis, inflammation, and energy metabolism through VEGF, ROS and HMGB1 signaling pathways in rats

Phytomedicine, Journal Year: 2023, Volume and Issue: 120, P. 155050 - 155050

Published: Aug. 26, 2023

Language: Английский

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The Protective Effects of Bushen Daozhuo Granule on Chronic Non-bacterial Prostatitis

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 4, 2024

Background: Chronic non-bacterial prostatitis (CNP), one of the most common chronic diseases in urology, leads to pain prostate and dysuria, critically affecting physical or mental health patients. However, there are no standard treatment approaches for CNP clinic. Although clinical application Bushen Daozhuo granule (BSDZG) offers hope patients China, mechanisms BSDZG treating still not entirely clear. Hence, we aimed investigate novel therapeutic on CNP. Methods: In this study, first assayed index rats then determined anti-inflammatory anti-apoptotic effects vivo vitro by employing ELISA kits TUNEL staining. Next, investigated whether protein-induced lipopolysaccharide (LPS) induced RWPE-1 cells were related AKT, p38 MAPK, NF-κB pathways with help Western blot. Finally, influence interaction between MAPK pathway LPS-induced was explored adopting dehydrocorydaline (DHC, activator) Results: , effectively reduced index. dramatically declined level two pro-inflammatory cytokines, TNF-α IL-1β, as well apoptosis rate. Moreover, memorably upregulated expression p-AKT, substantially downregulated p-p38 NF-κB2. The activation significantly reversed moderation NF-κB2 . Conclusion: To sum up, reflected anti-inflammation anti-apoptosis that formed inhibiting regulate pathways, effect realized suppressing inhibit downstream pathway.

Language: Английский

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Recent advances in the extraction, purification and analytical techniques for flavonoids from plants: Taking hawthorn as an example

Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107372 - 107372

Published: Feb. 1, 2025

Language: Английский

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Enhancement of wound healing by a bilayer hydrogel and nanofiber scaffold infused with Calophyllum inophyllum oil and Platostoma palustre aqueous extract

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 172, P. 214247 - 214247

Published: Feb. 27, 2025

Language: Английский

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Propagation and Breeding Approaches of Hosta spp.

Published: Jan. 1, 2025

Language: Английский

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From clinical observations to molecular insights: Decoding immune checkpoint inhibitors‐induced prostatitis

View, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Immune checkpoint inhibitors (ICIs) have dramatically transformed cancer treatment; however, their impact on the male reproductive system remains poorly understood. This study aims to elucidate incidence, risk factors, and molecular mechanisms underlying ICI‐associated prostatitis. We conducted an analysis of prostatitis utilizing U.S. Food Drug Administration Adverse Event Reporting System (FAERS) database evaluated through application reporting odds ratio. A mouse model ICI treatment was developed, subsequent transcriptomic changes in prostate tissue were investigated using high‐throughput sequencing. Hematoxylin eosin staining, immunohistochemistry, Von Frey testing, enzyme‐linked immunosorbent assay employed confirm ICI‐induced further delineate its mechanisms. Additionally, we therapeutic potential specifically targeting interleukin‐6 (IL‐6) extracellular signal‐regulated kinase (ERK) signaling pathways. FAERS demonstrated a statistically significant positive correlation between ( p < .05). In murine model, induced elevated inflammatory response tissue, characterized by enhanced cell infiltration upregulated expression IL‐6 tumor necrosis factor‐alpha. Transcriptomic revealed activation multiple inflammation‐related pathways following (false discovery rate 0.05). Targeted inhibition or ERK significantly attenuated symptoms, resulting improved pathology decreased factor .01). delineates characteristics prostatitis, thereby establishing theoretical foundation for development prevention strategies. modulation may present novel interventions thus warranting clinical validation.

Language: Английский

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Identification of bioactive ingredients and potential mechanisms of flowers of Hosta Plantaginea in treating pneumonia based on network pharmacology and experimental validation

Fitoterapia, Journal Year: 2024, Volume and Issue: 176, P. 106010 - 106010

Published: May 12, 2024

Language: Английский

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Ultrasound-assisted enzyme extraction of total flavonoids from lotus leaf (Nelumbo nucifera Gaertn.) and its antioxidant activity

LWT, Journal Year: 2024, Volume and Issue: unknown, P. 117224 - 117224

Published: Dec. 1, 2024

Language: Английский

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Hosta plantaginea (Lam.) Aschers flower modulates inflammation and amino acid metabolism by inhibiting NF-κB/MAPK/JAK-STAT/PI3K-Akt and AMPK pathways to alleviate benign prostatic hyperplasia in rats

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118970 - 118970

Published: Oct. 1, 2024

Language: Английский

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