Optimal design and experiment of bionic vacuum suckers with high attachment properties DOI
Dexue Zhang, Jun Xu, Qifeng Zhang

et al.

Journal of Adhesion Science and Technology, Journal Year: 2024, Volume and Issue: 38(18), P. 3480 - 3505

Published: May 1, 2024

Language: Английский

Exploring antithrombotic mechanisms and effective constituents of Lagopsis supina using an integrated strategy based on network pharmacology, molecular docking, metabolomics, and experimental verification in rats DOI

Qingcui Zhang,

Jian Liang, Xiaomei Li

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 336, P. 118717 - 118717

Published: Aug. 23, 2024

Language: Английский

Citations

10
Recent advances in the extraction, purification and analytical techniques for flavonoids from plants: Taking hawthorn as an example DOI
Zhe Han, Chunfeng Li, Guiyan Liu

et al.

Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107372 - 107372

Published: Feb. 1, 2025

Language: Английский

Citations

1
Lagopsis supina ameliorates myocardial ischemia injury by regulating angiogenesis, thrombosis, inflammation, and energy metabolism through VEGF, ROS and HMGB1 signaling pathways in rats DOI
Junwei He,

Qingcui Zhang,

Xiaoyi Xia

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 120, P. 155050 - 155050

Published: Aug. 26, 2023

Language: Английский

Citations

14
The Protective Effects of Bushen Daozhuo Granule on Chronic Non-bacterial Prostatitis DOI Creative Commons
Dalin Sun, D. Y. Xing, Dandan Wang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 4, 2024

Background: Chronic non-bacterial prostatitis (CNP), one of the most common chronic diseases in urology, leads to pain prostate and dysuria, critically affecting physical or mental health patients. However, there are no standard treatment approaches for CNP clinic. Although clinical application Bushen Daozhuo granule (BSDZG) offers hope patients China, mechanisms BSDZG treating still not entirely clear. Hence, we aimed investigate novel therapeutic on CNP. Methods: In this study, first assayed index rats then determined anti-inflammatory anti-apoptotic effects vivo vitro by employing ELISA kits TUNEL staining. Next, investigated whether protein-induced lipopolysaccharide (LPS) induced RWPE-1 cells were related AKT, p38 MAPK, NF-κB pathways with help Western blot. Finally, influence interaction between MAPK pathway LPS-induced was explored adopting dehydrocorydaline (DHC, activator) Results: , effectively reduced index. dramatically declined level two pro-inflammatory cytokines, TNF-α IL-1β, as well apoptosis rate. Moreover, memorably upregulated expression p-AKT, substantially downregulated p-p38 NF-κB2. The activation significantly reversed moderation NF-κB2 . Conclusion: To sum up, reflected anti-inflammation anti-apoptosis that formed inhibiting regulate pathways, effect realized suppressing inhibit downstream pathway.

Language: Английский

Citations

5
Ultrasound-assisted enzyme extraction of total flavonoids from lotus leaf (Nelumbo nucifera Gaertn.) and its antioxidant activity DOI Creative Commons

Chenlu Liu,

Furong Xu, Qing Zhang

et al.

LWT, Journal Year: 2024, Volume and Issue: unknown, P. 117224 - 117224

Published: Dec. 1, 2024

Language: Английский

Citations

4
Enhancement of wound healing by a bilayer hydrogel and nanofiber scaffold infused with Calophyllum inophyllum oil and Platostoma palustre aqueous extract DOI Creative Commons
Anh Hue Luong, Wei‐Chih Lin

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 172, P. 214247 - 214247

Published: Feb. 27, 2025

Language: Английский

Citations

0
Propagation and Breeding Approaches of Hosta spp. DOI
Hasan Mehraj, Imtiaz Faruk Chowdhury, Mohammad Shamim Hasan Mandal

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
From clinical observations to molecular insights: Decoding immune checkpoint inhibitors‐induced prostatitis DOI Creative Commons
Peng Luo,

Ying Liu,

Lan Xu

et al.

View, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Immune checkpoint inhibitors (ICIs) have dramatically transformed cancer treatment; however, their impact on the male reproductive system remains poorly understood. This study aims to elucidate incidence, risk factors, and molecular mechanisms underlying ICI‐associated prostatitis. We conducted an analysis of prostatitis utilizing U.S. Food Drug Administration Adverse Event Reporting System (FAERS) database evaluated through application reporting odds ratio. A mouse model ICI treatment was developed, subsequent transcriptomic changes in prostate tissue were investigated using high‐throughput sequencing. Hematoxylin eosin staining, immunohistochemistry, Von Frey testing, enzyme‐linked immunosorbent assay employed confirm ICI‐induced further delineate its mechanisms. Additionally, we therapeutic potential specifically targeting interleukin‐6 (IL‐6) extracellular signal‐regulated kinase (ERK) signaling pathways. FAERS demonstrated a statistically significant positive correlation between ( p < .05). In murine model, induced elevated inflammatory response tissue, characterized by enhanced cell infiltration upregulated expression IL‐6 tumor necrosis factor‐alpha. Transcriptomic revealed activation multiple inflammation‐related pathways following (false discovery rate 0.05). Targeted inhibition or ERK significantly attenuated symptoms, resulting improved pathology decreased factor .01). delineates characteristics prostatitis, thereby establishing theoretical foundation for development prevention strategies. modulation may present novel interventions thus warranting clinical validation.

Language: Английский

Citations

0
Rapid Two-Step Isolation of Kaempferol from the Hosta plantaginea Flower and Its Anti-Inflammatory Mechanism: Evidence from Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and Experimental Validation DOI Creative Commons
Yating Yang, Bowei Xia,

Huan Ouyang

et al.

Separations, Journal Year: 2025, Volume and Issue: 12(6), P. 138 - 138

Published: May 23, 2025

The rapid isolation of target constituents from natural products poses a significant challenge and is key focus in current research. Hosta plantaginea flower (HPF), traditional Chinese medicinal herb, primarily used to treat inflammatory diseases, with kaempferol as one its major bioactive constituents. In this study, macroporous adsorption resin was purify total flavonoids (TF) the HPFs. 50% ethanol–water elution fraction TF then recrystallized yield purity 99.44%. Network pharmacology analysis identified 61 potential kaempferol-inflammation targets, which were linked PI3K-Akt TNF signaling pathways. Molecular docking molecular dynamics simulations revealed stability binding PI3K, Akt, TNF-α proteins. metrics included ability, root mean square deviation (RMSD), radius gyration, free energy landscape, solvent-accessible surface area, hydrogen bond count, RMS fluctuation, energy, amino acid residue decomposition, principal component analysis. anti-inflammatory mechanism further validated an LPS-induced RAW264.7 cell model, where it shown inhibit This study provides new insights into presents novel strategies for products.

Language: Английский

Citations

0
Identification of bioactive ingredients and potential mechanisms of flowers of Hosta Plantaginea in treating pneumonia based on network pharmacology and experimental validation DOI
Zhiqiang Li, Yanhua Xu, Qinqin Wang

et al.

Fitoterapia, Journal Year: 2024, Volume and Issue: 176, P. 106010 - 106010

Published: May 12, 2024

Language: Английский

Citations

3