Development of White Cabbage, Coffee, and Red Onion Extracts as Natural Phosphodiesterase-4B (PDE4B) Inhibitors for Cognitive Dysfunction: In Vitro and In Silico Studies

Advances in Pharmacological and Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 39

Published: May 21, 2024

Human cognition fundamentally depends on memory. Alzheimer's disease exhibits a strong correlation with decline in this factor. Phosphodiesterase-4 B (PDE4B) plays crucial role neurodegenerative disorders, and its inhibition is one of the promising approaches for memory enhancement. This study aimed to identify secondary metabolites white cabbage, coffee, red onion extracts their molecular interaction PDE4B by

Language: Английский

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Solid-state fermentation using wheat bran to produce glucose syrup and functional cereal bars

Bioprocess and Biosystems Engineering, Journal Year: 2024, Volume and Issue: 47(7), P. 1081 - 1094

Published: May 13, 2024

Language: Английский

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Natural Products for Melanoma Therapy: From Traditional Medicine to Modern Drug Discovery

Plants, Journal Year: 2025, Volume and Issue: 14(6), P. 951 - 951

Published: March 18, 2025

Melanoma, a type of skin cancer originating from melanocytes, represents significant public health concern according to the World Health Organization. It is one most commonly diagnosed cancers worldwide, particularly affecting populations in Europe and North America, with an increasing incidence Asia. The rise emphasizes need for diversified treatment approaches. Conventional treatments melanoma, including immunotherapy, chemotherapy, targeted therapies like FDA-approved Opdivo Relatlimab, often come severe side effects high relapse rates. Consequently, natural products have gained considerable attention their potential enhance therapeutic outcomes reduce adverse effects. This systematic review evaluates anti-cancer properties against examining 52 studies PubMed Google Scholar. Our analysis focuses on antioxidant, anti-angiogenesis, anti-metastatic, apoptosis-inducing activities these compounds, also discussing regulatory factors involved. findings advocate intensified research into as complementary agents melanoma treatment, aiming improve efficacy patient quality life. Further vitro, vivo, clinical trials are essential validate effectiveness integrate them standard care protocols.

Language: Английский

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Novel Functional Food Properties of Forest Onion (Eleutherine bulbosa Merr.) Phytochemicals for Treating Metabolic Syndrome: New Insights from a Combined Computational and In Vitro Approach

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1441 - 1441

Published: May 10, 2024

Metabolic syndrome is a global health problem. The use of functional foods as dietary components has been increasing. One food interest forest onion extract (FOE). This study aimed to investigate the effect FOE on lipid and glucose metabolism in silico vitro using 3T3-L1 mouse cell line. was comprehensive that used multi-modal computational network pharmacology analysis molecular docking cells vitro. phytochemical were analyzed untargeted ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS). Next, an performed determine FOE’s bioactive compounds, toxicity analysis, protein target identification, pharmacology, carried out. pancreatic lipase, α-glucosidase, α-amylase inhibition determined. Finally, we determined its accumulation MAPK8, PPARG, HMGCR, CPT-1, GLP1 expression preadipocyte We showed potential metabolites targeted inhibited lipase levels, Furthermore, significantly (p < 0.05) inhibits expressions GLP-1 dose-dependent manner. contains several reduce α-amylase, proteins associated with

Language: Английский

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Ethanol Extract Dry Syrup Granulation Formulation Dayak Onion Bulb (Eleutherine bulbosa (Mill.) Urb.)

International Journal of Advancement in Life Sciences Research, Journal Year: 2024, Volume and Issue: 07(01), P. 103 - 109

Published: Jan. 1, 2024

Background: Dayak onion (Eleutherine bulbosa (Mill.) Urb.) is one kind of medicinal plant native to East Kalimantan that has antioxidant activity. The dosage form can be developed dry syrup granules which become the most simple forms in preparation, easy use, storage-stable and cover bitter taste drug. goal this study was find best mix Avicel PH 101 Na CMC make meet requirements for physical properties. Methods: Research carried out experimentally using three formulas with combinations Na-CMC. ratios Na-CMC were (1:0); (0.5:0.5) (0:1). evaluation included organoleptic observations, a moisture content test, flowability reconstitution time pH viscosity test hygroscopic test. Result: variation 1:0 have properties, i.e. 2.47%, flow 0.91 seconds, an angle repose 25.19 ° tap index 10.67%. Conclusion: Dry ratio (1:0) are preparations properties requirements, namely 25, 19° fixing

Language: Английский

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Application of Dayak Onion (Eleutherine bulbosa Urb.) as a Preservative for Animal Protein: Chicken Meat

International Journal of Multidisciplinary Applied Business and Education Research, Journal Year: 2024, Volume and Issue: 5(2), P. 375 - 382

Published: Feb. 21, 2024

The adoption of chicken meat as the primary protein source remains limited in Indonesia due to restrictions on its shelf life. Marinating with Dayak onion, known for antibacterial and antioxidant characteristics, can prolong meat's This research evaluates efficacy onion a natural preservative animal protein, specifically meat. study used qualitative experimental design featuring both control treatment groups. experiment involved testing pH value cooking loss that has been marinated powder (treatment) had not (control). process data analysis commenced application Saphiro-Wilk Test ascertain nature distribution. If distribution is found be normal, subsequent step involves conducting Independent-T test. Conversely, if determined non-normal, Mann-Whitney employed instead. findings indicated notable effect maintaining level flesh after 9 hours, opposed untreated (p0.05). overall demonstrate capacity an organic

Language: Английский

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Gastroprotective role of a flavonoid-rich subfraction from Fridericia chica (Bonpl.) L. G. Lohmann: a medicinal plant used in the Amazon region

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(5), P. 3499 - 3519

Published: Aug. 10, 2024

Language: Английский

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In Vitro Tyrosinase and Collagenase Inhibitory and Antioxidant Potential of Smyrnium rotundifolium Mill. and Euphorbia virgata Waldst.&Kit. from Türkiye

Cumhuriyet Science Journal, Journal Year: 2024, Volume and Issue: 45(4), P. 756 - 762

Published: Dec. 30, 2024

Antioxidants help prevent signs of aging and skin tone inequalities by protecting our from free radicals. High tyrosinase inhibition has a whitening effect on the skin, while collagenase an anti-sagging skin. Antioxidant activity tyrosinase/collagenase enzyme capacities have mutually supporting effects. The aim this study was to determine antioxidant activities, inhibitory potentials ethanol extracts two medicinal plants Turkey (Smyrnium rotundifolium Euphorbia virgata). In study, 6 different reference substances their chemical contents were investigated. Myricetin, quercetin kaempferol observed in S. extract, E. virgata extract. According capacity results measured both analyses; (IC50 DPPH•: 4.9±0.15 µg/mL, IC50 ABTS•+: 4.3±0.2 µg/mL) 4.6±0.11 4.1±0.13 similar each other. It determined that had higher anti-collagenase (27.9±0.13% inhibition) anti-tyrosinase (11.1±0.14% activities compared These showed us can be considered as strong candidate for management epidermal hyperpigmentation elasticity deserves further study.

Language: Английский

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Development and evaluation of in vitro and in vivo antioxidant activity of novel skincare formulation containing phytophospholipid complex

Annals of Phytomedicine An International Journal, Journal Year: 2023, Volume and Issue: 12(2)

Published: Dec. 1, 2023

Skin is the outermost layer of body, continuously exposed to external environment, harmful UV radiation, chemicals, and air pollutants.Chronic radiation exposure induces production reactive oxygen species (ROS), free radicals.Excessive radicals accumulates in skin body signifies oxidative stress.Oxidative stress destroys antioxidant system skin, results number effects on skin.Natural phenolic constituents plant possess strong radical scavenging potential, prevents effect associated with promote health.Low permeation phenolics due their polarity poor solubility, stability, dermal penetration.Aim this study was formulate evaluate activity cream formulations containing phytophospholipid complexes combination fractions.Phytophospholipid complex prepared by solvent evaporation method incorporating a fraction soya phospholipid different molar concentrations (1:1, 1:2, 2:2, 2:1).Various batches novel care were (1%, 2%, 3%, 4%, 5%) an optimized batch phytophsopholipid complex.Prepared are evaluated for pH, spreadability, viscosity, vitro effect, vivo effect.The result pharmaceutical evaluation all phytosomal showed that parameters normal range.Optimum found formulation (PCF5) as compared conventional extract.

Language: Английский

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Characterization of spice ingredients and raw soumbala for the formulation of a highly nutritious seasoning

Cogent Food & Agriculture, Journal Year: 2024, Volume and Issue: 10(1)

Published: Oct. 16, 2024

The formulation of food products is a very important part achieving safety and security through the provision healthy nutritious products. Success requires proper characterization basic components. Therefore, this study aimed to evaluate nutritional parameters some spices soumbala for formulating soumbala-based seasoning rich in bioactive compounds. Six (onion, parsley, anise, chili, black pepper, guinea pepper) were used study. Physicochemical biochemical evaluated using standard methods. Results showed that acidity ranged from 1.22%-4.26% pepper Parsley respectively. pH onion was most acidic (5.73). Soumbala slightly (7.21). dry matter content 86.44%-94.34% green aniseed, richer protein (35.27%) anise had lowest (10.54%). lipids, more energetic, while carbohydrates. Considering these high macromolecular contents their richness micronutrients compounds, with an appropriate blend ingredients would provide functional wellbeing consumers.

Language: Английский

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