Natural agents that are neuroprotective against mitochondria: a bibliometric-based research mapping 1998–2024, from cells to mitochondria DOI Creative Commons
ARMAN YURISALDI SALEH,

Dwi Arwandi Yogi Saputra

F1000Research, Journal Year: 2024, Volume and Issue: 13, P. 754 - 754

Published: Oct. 23, 2024

Introduction Mitochondria are cell organelles that function as the cell’s main power plant, producing ATP, energy molecule in cells. play an important role context of neuroprotection, and mitochondrial has been implicated various neurodegenerative diseases, including Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS). Recent research field neuroprotection focused on development therapies target mitochondria. Natural ingredients have long used traditional medicine show potential neuroprotective agents. Methods In this work, a literature review methodology is employed to gather data from Scopus database using keywords natural agents, herb*, neuroprotective, The were analyzed Biblioshiny VOSviewer software produce visualizations bibliometric maps. We conducted quantitative qualitative analyses. Results trend found documents by year, most global cited document, relevant sources, A factorial map illustrating leading contributors papers, author, country or territory, subject area, network visualization, overlay visualization scopus vosviewer, density thematic map, evolution, cluster analysis, word cloud. Conclusions Agent Neurotropik substance influences brain’s nervous system peripheral system, enhancing cognition, mood, brain function. Derived herbs, spices, herbal products, it advantages over other agents production, biogenesis, neuroprotection. agents’ compositional heterogeneity affects reproductive results. Proper characterization standardized extraction techniques crucial for establishing plant extracts’ chemical profile. Dosage consistency essential Long-term safety toxicity should be evaluated. Comparing medicines with synthetic pharmaceuticals can enhance therapy efficacy reduce drug resistance. Further needed assess function.

Language: Английский

New triterpenoid saponins isolated from the leaves of Astragalus membranaceus (Fisch.) Bge. and their neuroprotective effects DOI
Wenxiang Xu, Xinyuan Li, Qian Zhang

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 156, P. 108149 - 108149

Published: Jan. 9, 2025

Language: Английский

Citations

1
Exploring the active components and potential mechanisms of Zhimu-Huangbai herb-pair in the treatment of depression DOI
Xia Lei,

Deping Zhao,

Tongtong Chen

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156365 - 156365

Published: Jan. 1, 2025

Language: Английский

Citations

1
Anemarrhena asphodeloides Bunge and Phellodendri Chinensis Cortex inhibits the PTGS2/EP2/cAMP/Epac1 signaling pathway to reduce microglial M1 polarization, thereby blocking chronic stress-induced depression-like behavior DOI Creative Commons
Deping Zhao, Ao X, Ke Yuan

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119792 - 119792

Published: April 1, 2025

Anemarrhena asphodeloides Bunge and Phellodendri Chinensis Cortex (AP) is a synergistic drug combination used to treat depression. However, the molecular mechanism underlying therapeuticeffects of AP requires further elucidation. To investigate potential in treatment depression its action. The model was established by chronic unpredictable mild stress (CUMS) treated with different doses AP. UPLC-Q-TOF-MS/MS network pharmacology methods were analyze composition targets Molecular docking, affinity ultrafiltration (AUF) cellular thermal shift assays (CETSA) techniques interaction between components key targets. therapeutic effects active ingredients explored LPS-induced cell models. ameliorated CUMS-induced despair behaviors, regulate M1 / M2 phenotypic balance microglia reduced neuroinflammation. Then, A total 10 brain identified mPFC CUMS rats. Based on these chemical compositions, PTGS2 found be at core regulatory through analysis. All had good PTGS2, among which Neomangiferin strongest binding capacity. can decrease activity, PGE2 production EP2 expression downstream, reduce inflammatory response. In BV2 cells, regulated imbalance M1/M2 microglia, release pro-inflammatory factors, decreased PEG2, EP2, cAMP, Epac1. improves benefits targeting signaling pathway, thereby promoting wider use

Language: Английский

Citations

0
Exploring the chemistry, biological effects, and mechanism insights of natural coumaroyltyramine: First report DOI

Saad Bakrim,

Youssef Elouafy,

Jihane Touhtouh

et al.

Fitoterapia, Journal Year: 2024, Volume and Issue: 178, P. 106182 - 106182

Published: Aug. 15, 2024

Language: Английский

Citations

1
Panax Quinquefolium Saponins protects neuronal activity by promoting mitophagy in both in vitro and in vivo models of Alzheimer's disease DOI
Wei Zhao, Rui Yang, Xin Meng

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 119250 - 119250

Published: Dec. 1, 2024

Language: Английский

Citations

1
Exploration of effective biomarkers for venous thrombosis embolism in Behçet’s disease based on comprehensive bioinformatics analysis DOI Creative Commons
Chunjiang Liu, Yuan Wang,

Zhifeng Wu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 10, 2024

Behçet's disease (BD) is a multifaceted autoimmune disorder affecting multiple organ systems. Vascular complications, such as venous thromboembolism (VTE), are highly prevalent, around 50% of individuals diagnosed with BD. This study aimed to identify potential biomarkers for VTE in BD patients. Three microarray datasets (GSE209567, GSE48000, GSE19151) were retrieved analysis. Differentially expressed genes (DEGs) associated identified using the Limma package and weighted gene co-expression network analysis (WGCNA). Subsequently, diagnostic explored through protein-protein interaction (PPI) machine learning algorithms. A receiver operating characteristic (ROC) curve nomogram constructed evaluate performance Furthermore, immune cell infiltration analyses single-sample set enrichment (ssGSEA) performed investigate underlying mechanisms. Finally, efficacy listed drugs was assessed based on signature genes. The limma WGCNA 117 DEGs related PPI then selected 23 candidate hub Four (E2F1, GATA3, HDAC5, MSH2) by intersecting sets from three ROC construction demonstrated high accuracy these four (AUC: 0.816, 95% CI: 0.723-0.909). Immune revealed positive correlation between dysregulated cells ssGSEA provided insights into mechanisms development progression Additionally, therapeutic agent screening targeting employed systematic approach construct diagnosis dysregulation, suggesting macrophage involvement development. BD-induced VTE, agents identified.

Language: Английский

Citations

0
Natural agents that are neuroprotective against mitochondria: a bibliometric-based research mapping 1998–2024, from cells to mitochondria DOI Creative Commons
ARMAN YURISALDI SALEH,

Dwi Arwandi Yogi Saputra

F1000Research, Journal Year: 2024, Volume and Issue: 13, P. 754 - 754

Published: July 5, 2024

Introduction Mitochondria are cell organelles that function as the cell’s main power plant, producing ATP, energy molecule in cells. play an important role context of neuroprotection, and mitochondrial has been implicated various neurodegenerative diseases, including Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS). Recent research field neuroprotection focused on development therapies target mitochondria. Natural ingredients have long used traditional medicine show potential neuroprotective agents. Methods In this work, a literature review methodology is employed to gather data from Scopus database using keywords natural agents, herb*, neuroprotective, The were analyzed Biblioshiny VOSviewer software produce visualizations bibliometric maps. We conducted quantitative qualitative analyses. Results trend found documents by year, most global cited document, relevant sources, A factorial map illustrating leading contributors papers, author, country or territory, subject area, network visualization, overlay visualization scopus vosviewer, density thematic map, evolution, cluster analysis, word cloud. Conclusions Agent Neurotropik substance influences brain’s nervous system peripheral system, enhancing cognition, mood, brain function. Derived herbs, spices, herbal products, it advantages over other agents production, biogenesis, neuroprotection.

Language: Английский

Citations

0
Exploration of the pharmacological components and therapeutic mechanisms in treatment of Alzheimer's disease with Polygonati Rhizoma and its processed product using combined analysis of metabolomics, network pharmacology, and gut microbiota DOI Creative Commons
Xiaojuan Liao, Hongmei Liu,

Wang Zhu-xin

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35394 - e35394

Published: July 30, 2024

Polygonati Rhizoma (PR, Huangjing in Chinese) and its processed product (PRP), which are used Traditional Chinese medicine (TCM) for cognitive enhancement treatment of Alzheimer's disease (AD), have not been fully explored terms the different mechanisms underlying their anti-AD effects. Therefore, we APP/PS1 mice as an AD model to assess effects PR PRP on anxiety-like behaviors, function, memory performance, pathological changes murine brain. UPLC-HRMS was applied identify components that entered into blood Network pharmacology elucidate potential improvement AD. Differences intestinal flora composition between treated with were investigated using 16S rRNA sequencing, establishing a correlation pharmacological distinct profiles. The results revealed both interventions ameliorated deficits attenuated Amyloid β (Aβ) plaque deposition brains mice. Seven specific blood-entering components, namely glutamic acid, Phe-Phe, uridine, etc., associated intervention, whereas ten including (2R,3S)-3-isopropylmalate, 3-methylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione, 3-methoxytyrosine related intervention. Uridine identified common brain-penetrating component interventions. analysis suggested NOD-like receptor signaling pathway, Calcium pathway pathways targeted Moreover, apoptosis specifically linked during Furthermore, administration enhanced abundance diversity Western blotting confirmed excels regulates inflammation, balances autophagy alleviate progression This study offers valuable insights establishes robust foundation further comprehensive exploration intrinsic TCM

Language: Английский

Citations

0
Mechanism of ginsenoside Rb3 against OGD/R damage based on metabonomic and PCR array analyses DOI Open Access
Fuhui Li, Jie Tao, Mingmin Zhou

et al.

Biomedical Reports, Journal Year: 2024, Volume and Issue: 21(6)

Published: Oct. 9, 2024

In order to study the mechanisms of ginsenoside Rb

Language: Английский

Citations

0
Natural agents that are neuroprotective against mitochondria: a bibliometric-based research mapping 1998–2024, from cells to mitochondria DOI Creative Commons
ARMAN YURISALDI SALEH,

Dwi Arwandi Yogi Saputra

F1000Research, Journal Year: 2024, Volume and Issue: 13, P. 754 - 754

Published: Oct. 23, 2024

Introduction Mitochondria are cell organelles that function as the cell’s main power plant, producing ATP, energy molecule in cells. play an important role context of neuroprotection, and mitochondrial has been implicated various neurodegenerative diseases, including Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS). Recent research field neuroprotection focused on development therapies target mitochondria. Natural ingredients have long used traditional medicine show potential neuroprotective agents. Methods In this work, a literature review methodology is employed to gather data from Scopus database using keywords natural agents, herb*, neuroprotective, The were analyzed Biblioshiny VOSviewer software produce visualizations bibliometric maps. We conducted quantitative qualitative analyses. Results trend found documents by year, most global cited document, relevant sources, A factorial map illustrating leading contributors papers, author, country or territory, subject area, network visualization, overlay visualization scopus vosviewer, density thematic map, evolution, cluster analysis, word cloud. Conclusions Agent Neurotropik substance influences brain’s nervous system peripheral system, enhancing cognition, mood, brain function. Derived herbs, spices, herbal products, it advantages over other agents production, biogenesis, neuroprotection. agents’ compositional heterogeneity affects reproductive results. Proper characterization standardized extraction techniques crucial for establishing plant extracts’ chemical profile. Dosage consistency essential Long-term safety toxicity should be evaluated. Comparing medicines with synthetic pharmaceuticals can enhance therapy efficacy reduce drug resistance. Further needed assess function.

Language: Английский

Citations

0