European Journal of Gastroenterology & Hepatology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 17, 2024
Gastric
intestinal
metaplasia
(GIM)
is
a
pathological
process
where
gastric
mucosal
epithelial
cells
are
replaced
by
intestinal-type
cells,
serving
as
precursor
lesion
for
cancer.
This
transformation
involves
various
genetic
and
environmental
factors,
affecting
key
genes
signaling
pathways.
Recent
research
has
revealed
complex
mechanisms,
including
changes
in
gene
expression,
abnormal
pathway
activation,
altered
cell
behavior.
review
summarizes
the
latest
on
GIM,
discussing
its
pathogenesis,
current
treatment
strategies,
potential
efficacy
of
emerging
approaches
like
editing,
microbiome
interventions,
integrative
medicine.
By
exploring
these
we
aim
to
provide
more
effective
treatments
GIM
reduce
cancer
incidence.
The
also
highlights
importance
interdisciplinary
studies
understanding
mechanisms
improving
strategies.
World Journal of Gastroenterology,
Journal Year:
2025,
Volume and Issue:
31(9)
Published: Feb. 18, 2025
Chronic
atrophic
gastritis
(CAG)
is
an
important
stage
of
precancerous
lesions
gastric
cancer.
Effective
treatment
and
regulation
CAG
are
essential
to
prevent
its
progression
malignancy.
Traditional
Chinese
medicine
(TCM)
has
shown
multi-targeted
efficacy
in
treatment,
with
advantages
enhancing
mucosal
barrier
defense,
improving
microcirculation,
modulating
inflammatory
immune
responses,
promoting
lesion
healing,
etc.
Clinical
studies
meta-analyses
indicate
that
TCM
provides
significant
benefits,
specific
herbal
compounds
monomers
demonstrating
protective
effects
on
the
mucosa
through
mechanisms
including
anti-inflammation,
anti-oxidation,
cellular
proliferation
apoptosis,
Finally,
it
pointed
out
requires
standardized
research
unified
standards,
constantly
clarifies
improves
evaluation
criteria
each
dimension
function.
Journal of Cellular and Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
29(4)
Published: Feb. 1, 2025
ABSTRACT
Chronic
atrophic
gastritis
(CAG)
is
a
precancerous
lesion
characterised
by
gastric
mucosal
atrophy
and
inflammation.
Identifying
key
molecular
mechanisms
potential
therapeutic
targets
essential
to
improve
patient
outcomes.
Key
modules
differentially
expressed
genes
(DEGs)
were
recognised
in
the
GSE153224
dataset
using
weighted
gene
co‐expression
network
analysis
(WGCNA)
examination
of
differential
expression.
IGFBP7
was
identified
as
hub
protein–protein
interaction
(PPI)
expression
validation.
CAG
patients’
blood
parameters
health
status
evaluated
before
after
treatment
vitamin
C
(VC).
In
addition,
we
investigated
effects
VC
N‐methyl‐N′‐nitro‐N‐nitrosoguanidine
(MNNG)
on
GES‐1
cells,
including
cell
viability,
apoptosis
inflammatory
angiogenic
markers.
WGCNA
that
blue
module
significantly
associated
with
correlation
coefficient
0.924.
Among
93
overlapping
genes,
notably
underexpressed
selected
gene.
ROC
confirmed
high
diagnostic
performance
.
patients
treated
showed
significant
improvement
improved
health.
vitro,
increased
reduced
cytotoxicity
lowered
COX‐2
apoptosis‐related
protein
MNNG‐treated
cells.
Knockdown
further
influenced
these
effects.
MNNG
upregulated
HIF‐1α/VEGF
signalling
proteins,
which
attenuated.
Combined
knockdown
protective
This
study
highlights
regulatory
role
demonstrates
their
for
improving
mitigating
Infection and Drug Resistance,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 1215 - 1222
Published: Feb. 1, 2025
Epidermolysis
bullosa
(EB)
is
a
group
of
rare
genetic
skin
disorders
that
are
hereditary
and
heterogeneous,
characterized
by
mucosal
fragility
blister
formation,
often
induced
minimal
trauma.
Esophageal
complications
represent
significant
extracutaneous
manifestation
EB.
The
lack
standardized
diagnostic
therapeutic
guidelines
EB
with
esophageal
contributes
to
inconsistent
management
higher
susceptibility
recurrence.
For
patients
experiencing
digestive
tract
symptoms,
there
few
reports
specifically
address
the
follow-up
continuity
repair
treatment.
To
date,
co-infection
Helicobacter
pylori
(H.
pylori)
has
been
rarely
reported.
impact
H.
infection
on
remains
unclear.
Here,
we
report
case
26-year-old
man
diagnosed
complications.
patient
presented
post-sternal
pain,
dysphagia,
obstruction,
vomiting.
Gastroscopy
revealed
scattered
flake
erosions
mucosa.
pathological
examination
inflammatory
granulation
tissue
necrosis
focal
squamous
epithelium
showing
mild
atypical
hyperplasia.
Significant
improvement
in
symptoms
was
observed
after
long-term
therapy.
After
being
lost
follow-up,
developed
symptomatic
exacerbation
pylori.
patient's
condition
improved
eradication
pylori,
combined
ongoing
treatment
for
regular
follow-up.
Patients
who
have
require
Co-infection
may
be
an
important
factor
disease
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 13, 2025
As
a
critical
juncture
in
the
pathological
continuum
from
gastritis
to
gastric
cancer,
precancerous
lesions
of
cancer
(PLGC)
are
increasingly
prevalent,
significantly
undermining
health
global
population.
The
primary
constituents
bile,
specifically
bile
acids
(BAs),
disrupt
equilibrium
hormone
secretion
and
compromise
structural
integrity
mucosa,
thereby
facilitating
oncogenesis.
Moreover,
gut
microbiota
modulate
host
physiological
processes
through
immune
response
regulation,
metabolic
pathway
interference,
direct
interaction
with
tumor
cells.
Extensive
research
has
elucidated
that
dysregulation
BAs
microbiota,
concert
resultant
impairment
central
pathogenesis
PLGC.
In
anticipation
future
clinical
preventive
therapeutic
strategies,
this
review
collates
recent
insights
into
roles
bacteria
PLGC,
examining
their
interplay
significance
pathogenic
mechanism
Cell Biology International,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
ABSTRACT
Piwei
Peiyuan
(PWPY)
prescription
is
a
traditional
Chinese
medicine
and
has
been
efficiently
used
in
the
clinics
to
treat
chronic
atrophic
gastritis
(CAG)
for
many
years.
However,
mechanism
of
action
underlying
PWPY
treating
CAG
remains
elusive.
A
rat
animal
cell
model
was
constructed
this
study
explore
CAG.
Here
we
show
that
attenuates
progression
by
eliciting
MAPK10‐mediated
mitochondrial
autophagy.
Experimental
introduced
using
N
‐methyl‐n'‐nitro‐n‐nitroguanidine
(MNNG).
Our
histological
analyses
reveal
MNNG‐induced
undergoes
classical
morphological
alterations
judged
immunohistochemistry
serum
level
PGⅠ,
PGⅡ,
G17.
Importantly,
treatment
prevents
Interestingly,
inhibits
MAPK10
activity
biochemical
assays
promotes
autophagy
electron
microscopic
analyses.
Thus,
conclude
precancerous
lesions
harnessing
MAPK10‐elicited
The
experimental
provides
robust
platform
further
delineating
therapeutic
targets
regimen.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(9), P. 4541 - 4554
Published: July 25, 2024
Intestinal
metaplasia
(IM)
is
a
premalignant
condition
that
increases
the
risk
for
subsequent
gastric
cancer
(GC).
Traditional
Chinese
medicine
generally
plays
role
in
treatment
of
IM,
and
phytochemical
naringenin
used
herbal
has
shown
therapeutic
potential
diseases.
However,
naringenin's
specific
effect
on
IM
not
yet
clearly
understood.
Therefore,
this
study
identified
gene
targets
through
bioinformatics
analysis
experiment
validation.
Two
genes
(MTTP
APOB)
were
selected
as
after
comparison
RNA-seq
results
clinical
samples,
GEO
dataset
(GSE78523),
naringenin-related
from
GeneCards
database.
The
both
cell
animal
experiments
suggested
can
improve
changes
intestinal
epithelial
model
via
MTTP/APOB
expression.
In
summary,
likely
inhibits
axis
therefore
progression.
These
support
development
an
anti-IM
agent
may
contribute
to
discovery
novel
targets.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 7, 2024
Chronic
atrophic
gastritis
(CAG)
is
a
complex
chronic
disease
caused
by
multiple
factors
that
frequently
occurs
in
the
clinic.
The
worldwide
prevalence
of
CAG
high.
Interestingly,
clinical
patients
often
present
with
variety
symptom
phenotypes,
which
makes
it
more
difficult
for
clinicians
to
treat.
Therefore,
there
an
urgent
need
improve
our
understanding
complexity
population,
obtain
accurate
subtypes,
and
explore
relationship
between
symptoms
medication.
based
on
integrated
platform
networks
research,
we
classified
collected
according
their
different
characteristics
conducted
correlation
analysis
classification
results
identify
subtypes
aid
personalized
treatment.
