Structural Characters and Pharmacological Activity of Protopanaxadiol‐Type Saponins and Protopanaxatriol‐Type Saponins from Ginseng
Advances in Pharmacological and Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Ginseng
has
a
long
history
of
drug
application
in
China,
which
can
treat
various
diseases
and
achieve
significant
efficacy.
Ginsenosides
have
always
been
deemed
important
ingredients
for
pharmacological
activities.
Based
on
the
structural
characteristics
steroidal
saponins,
ginsenosides
are
mainly
divided
into
protopanaxadiol‐type
saponins
(PDS,
including
Rb1,
Rb2,
Rd,
Rc,
Rh2,
CK,
PPD)
protopanaxatriol‐type
(PTS,
Re,
R1,
Rg1,
Rh1,
Rf,
PPT).
The
structure
differences
between
PDS
PTS
result
This
paper
provides
an
overview
PTS,
focusing
their
chemical
profile,
pharmacokinetics,
hydrolytic
metabolism,
activities
antioxidant,
antifatigue,
antiaging,
immunodulation,
antitumor,
cardiovascular
protection,
neuroprotection,
antidiabetes.
It
is
intended
to
contribute
in‐depth
study
relationship
PTS.
Language: Английский
Guiding precision medicine strategy for intravenous ginsenosides via pharmacokinetic-informed bioinformatic approaches: a study on XueShuanTong
Weiwei Jia,
No information about this author
Nan-Nan Tian,
No information about this author
Zijing Song
No information about this author
et al.
Phytomedicine,
Journal Year:
2025,
Volume and Issue:
143, P. 156716 - 156716
Published: May 1, 2025
Language: Английский
Ginsenoside Rb3 represses CPZ-induced demyelination and neuroinflammation by inhibiting TRAF6 K63 ubiquitination
International Immunopharmacology,
Journal Year:
2025,
Volume and Issue:
158, P. 114800 - 114800
Published: May 9, 2025
Language: Английский
Structural Elucidation and In Silico-Aided Toxicity Prediction of Forced Degradation Products of Ginsenoside Re Using Ultra-High-Performance Liquid Chromatography Equipped with a Diode Array Detector and Charged Aerosol Detector (UHPLC-DAD-CAD) and Liquid Chromatography Coupled to a High-Resolution Mass Detector (LC-HRMS)
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13231 - 13231
Published: Dec. 10, 2024
Ginsenoside
Re
was
the
major
bioactive
component
found
rich
in
Panax
ginseng
C.
A.
Meyer,
which
exerted
excellent
cardiovascular
protection,
anti-inflammatory,
and
anti-oxidation
effects.
The
generation
of
unexpected
degradation
products
(DPs)
may
influence
therapeutic
effect
Re,
or
even
bring
toxic
effects
to
patients.
However,
date,
only
a
few
reports
were
available
about
stability
Re.
present
study
aims
systematically
investigate
behaviors
under
different
stress
conditions,
including
hydrolysis
(acidic,
basic,
neutral),
oxidation,
humidity,
thermal,
photolytic
(ultraviolet
visible
light)
conditions.
A
total
thirteen
DPs
putatively
identified,
among
them,
nine
discovered
for
first
time
our
study.
results
showed
that
sensitive
exposure
acidic,
oxidation
It
underwent
series
chemical
reactions,
deglycosylation,
dehydration,
addition,
at
double
bond,
isomerization
various
Structural
characterization
these
carried
out
by
UHPLC-DAD-CAD
LC-LTQ/Orbitrap.
plausible
mechanism
their
formation
proposed
support
structures
all
In
silico
toxicity
prediction
metabolism
behavior
assessment
done
Derek
Nexus
Meteor
software.
DP-1
DP-6
predicted
possess
potential
skin
irritation/corrosion
toxicity.
DP-11
DP-12
bear
carcinogenicity,
mutagenicity,
irritation,
hepatotoxicity,
sensitization.
observation
updates
knowledge
regarding
provides
valuable
information
quality
control
choose
suitable
storage
Language: Английский