Tanacetum parthenium and parthenolide increase defensive agents and promote antisecretory activity supporting their gastroprotective actions in rodents DOI

Cleidiane Vedoy Ferraz,

Amanda Maria Steffler, Cristian Alex Dalla Vecchia

et al.

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Nov. 6, 2024

Tanacetum parthenium is popularly used to treat gastric disorders. However, the gastroprotective activity has not yet been tested. This study evaluated anti-ulcer effects of hydroalcoholic extract from T. (HETp) and parthenolide (PTL), its bioactive compound. Our findings revealed a significant reduction in HETp (10, 30, or 100 mg/Kg) PTL (5 50 ethanol piroxicam-induced ulcers, this evidence was corroborated histologically. In addition, we explored acid antisecretory by pylorus ligation. Moreover, mice pre-treated with inhibitors indomethacin, L-NAME, yohimbine, antiulcerogenic were abolished, suggesting involvement nitric oxide, adrenergic receptors prostaglandins effects. Additionally, prevented depletion SOD CAT decreased MPO levels GSH LPO. The results suggest that gastroprotection involves different pharmacological pathways.

Language: Английский

Evaluation of Antiulcer Activity of Ethanolic Extract of Leaf, Bark, Flower and Fruit Pulp of <i>Cassia fistula</i> in Wistar Rats DOI
Dinesh Kumar Sharma, Suresh Kumar Sharma, Rajendra Damu Patil

et al.

Toxicology International, Journal Year: 2025, Volume and Issue: unknown, P. 49 - 56

Published: March 12, 2025

The present study was conducted to investigate the gastro-protective effects of Cassia fistula L. extracts on ethanolinduced gastric ulcers in rats. Forty-two male Wistar rats were divided into seven groups with six each group. Group I administered 0.5ml/day 0.5% Carboxymethyl Cellulose (CMC), II received ethanol (0.5ml/ day 50% ethanol), Groups III–VI (0.5ml /day ethanol) and C. leaf, bark, flower fruit pulp ethanolic @ 100 mg/kg/day respectively. VII ranitidine 50mg/kg for two weeks. On 15, ulceration stomach scored; ulcer index percentage protection calculated. Histopathological assess effect toxicities. Oral administration produced severe lesions treated All showed against ulcers. maximum (52.0%) shown by bark followed leaf which 49.7%. findings further confirmed protective extracts. suggests that have an ameliorative ethanol-induced damage Major Findings: suggested Ethanolic Extract Leaf, Bark, Flower Fruit Pulp

Language: Английский

Citations

0
Rubiáceas brasileiras com potencial anti-inflamatório DOI Creative Commons
Ana Paula da Silva,

Dionys de Souza Almeida,

Ana Maria Sampaio Assreuy

et al.

DELOS Desarrollo Local Sostenible, Journal Year: 2024, Volume and Issue: 17(56), P. e1492 - e1492

Published: June 6, 2024

A busca por novas estratégias terapêuticas para tratar doenças inflamatórias, com foco em produtos naturais como ferramentas alternativas tem aumentado. Este manuscrito revisa espécies brasileiras pertencentes à família Rubiaceae, seus respectivos fitoconstituintes que apresentam atividades e mecanismos anti-inflamatórios modelos experimentais. Para a foram utilizadas as bases de dados eletrônicas Web of Science, Pubmed, Science Direct “Periódicos CAPES” os sites World Flora Online Plant List Reflora verificar ocorrência da planta no Brasil. Sessenta cinco (65) manuscritos selecionados contemplando 39 espécies. Muitas Rubiaceae exibem farmacológicas através inibição citocinas, mediadores derivados lipídios enzimas, entre outros do processo inflamatório. Nossos achados revelam Uncaria tomentosa Morinda citrifolia mais estudadas. Assim, esta revisão fornece atualizações importantes sobre estas ressaltando-as fontes promissoras compostos o desenvolvimento novos complementares medicamentos anti-inflamatórios.

Citations

0
Anticancer Activity and Mechanism of Action of Couroupita guianensis Bark Decoction in Gastric Adenocarcinoma Cancer Cell Line DOI Open Access
Simona Pisanti, Serena Penna, Silvia Sposito

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9183 - 9183

Published: Aug. 24, 2024

Couroupita guianensis, a medicinal plant autochthonal to South America and India, is widely used in the ethnomedicine of indigenous peoples these regions thanks its alleged antimicrobial, anti-inflammatory, antioxidant wound-healing properties. The majority studies have mainly analyzed organic extracts Indian plant’s flowers leaves, with limited research on bark decoction, traditionally Amazonian shamanic medicine. In this study, we investigated anticancer effects decoction main fractions obtained through chromatographic separation, as well underlying molecular mechanisms AGS gastric cancer cells. Viability, cell proliferation, cycle, apoptosis protein expression related processes were evaluated. Both fraction III significantly inhibited viability, cytotoxic effect was linked cycle blockade induction also an engulfment autophagic flux. Increased or activation key proteins (p53, p21, cdk2, Bak, caspases, pAMPK, pAkt, beclin, p62 LC3BII) involved observed. results confirmed important C. guianensis providing scientific validation for use traditional medicine highlighting potential therapeutic agent against cancer.

Language: Английский

Citations

0
A Histopathological Study on the Deleterious Effect of Chronic Levothyroxine Sodium Administration on the Gastric Mucosa of Adult Male Albino Rats DOI

Rabab M. Amer,

Shaimaa M. Motawea,

Walaa S. Elseady

et al.

Journal of Microscopy and Ultrastructure, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Language: Английский

Citations

0
Tanacetum parthenium and parthenolide increase defensive agents and promote antisecretory activity supporting their gastroprotective actions in rodents DOI

Cleidiane Vedoy Ferraz,

Amanda Maria Steffler, Cristian Alex Dalla Vecchia

et al.

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Nov. 6, 2024

Tanacetum parthenium is popularly used to treat gastric disorders. However, the gastroprotective activity has not yet been tested. This study evaluated anti-ulcer effects of hydroalcoholic extract from T. (HETp) and parthenolide (PTL), its bioactive compound. Our findings revealed a significant reduction in HETp (10, 30, or 100 mg/Kg) PTL (5 50 ethanol piroxicam-induced ulcers, this evidence was corroborated histologically. In addition, we explored acid antisecretory by pylorus ligation. Moreover, mice pre-treated with inhibitors indomethacin, L-NAME, yohimbine, antiulcerogenic were abolished, suggesting involvement nitric oxide, adrenergic receptors prostaglandins effects. Additionally, prevented depletion SOD CAT decreased MPO levels GSH LPO. The results suggest that gastroprotection involves different pharmacological pathways.

Language: Английский

Citations

0