Medicine and food homology substances: A review of bioactive ingredients, pharmacological effects and applications

Food Chemistry, Journal Year: 2024, Volume and Issue: 463, P. 141111 - 141111

Published: Sept. 6, 2024

Language: Английский

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6-Paradol Enhances Sorafenib's Effects Against Colorectal Cancer and Promotes Active Metabolite Formation

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 269, P. 155876 - 155876

Published: Feb. 28, 2025

Language: Английский

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Linagliptin Mitigates DMH‐Induced Colorectal Cancer in Rats: Crosstalk Between NFAT and IL‐6/JAK2/STAT3/NF‐κB Signaling Hubs

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(3)

Published: March 1, 2025

ABSTRACT Colorectal cancer (CRC) is a multicomponent disease and the second most frequent root of cancer‐related deaths globally. Linagliptin dipeptidyl peptidase‐4 (DPP‐4) inhibitor. It has been repurposed in recent experimental studies due to its marked anti‐inflammatory activities. This study aimed evaluate ameliorative role linagliptin 1,2‐dimethylhydrazine (DMH)‐induced CRC via modulation NFAT‐mediated IL‐6 JAK2/STAT3/NF‐κB signaling pathways. model successfully established dose equal 40 mg/kg two times week DMH for 8‐week duration. Twenty‐four Wistar rats were segregated into three groups eight each; normal control, DMH‐induced + (10 mg/kg; p.o). attenuated oxidative stress by restoring declined levels some antioxidant enzymes. suppressed elevated nuclear factor kappa B (NF‐κB) induced which highlighted using immunohistochemistry analysis. The fortified decline activated T‐cells (NFAT) mRNA expression level along with reduction vascular endothelial growth (VEGF), interlukin‐6 (IL‐6) cyclooxygenase‐2 (COX‐2) levels. mitigate protein DMH‐activated oncogenic janus‐activated kinase/signal transducers activators transcription (JAK2/STAT3). exerted proapoptotic effect tumor cells manifested remarkable B‐cell lymphoma 2 (Bcl‐2) significant elevation Bcl‐2‐associated X (Bax) histopathological analysis revealed that inhibitory potential against dysplastic aberrant crypt foci (ACF) adenocarcinoma. ameliorated modulating cascades.

Language: Английский

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Mentha haplocalyx Briq. (Mint): a comprehensive review on the botany, traditional uses, nutritional value, phytochemistry, health benefits, and applications

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Dec. 12, 2024

Abstract Mentha haplocalyx Briq. ( M. ), a notable member of the Lamiaceae family, occupies significant role in realm health foods and botanical medicines. Traditionally, it has been employed to address various diseases, including colds, coughs, fever, indigestion, asthma, influenza. Recent phytochemical investigations have identified presence terpenoids, flavonoids, phenolic acids, anthraquinones, alkanes, polysaccharides , with terpenoids being primary bioactive constituents. Notably, both vitro vivo studies demonstrated its diverse benefits, such as neuroprotective, anti-asthmatic, anti-inflammatory, gut improvement, hypoglycemic, anti-aging, anti-bacterial, antioxidant effects. Additionally, is rich source carbohydrates, dietary fiber, amino minerals, vitamins, further underscoring nutritional value. A thorough literature review was conducted using databases like PubMed, Google Scholar, Web Science, China National Knowledge Infrastructure (CNKI) consolidate existing knowledge on . This synthesizes recent advancements botany, traditional uses, value, phytochemistry, research edible uses Furthermore, commercial potential future opportunities for are briefly explored, goal fostering continued interest this multifunctional plant inspiring endeavors. Graphical

Language: Английский

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Herbal diets: Directions for improving health and wellness

Nutrition and Health, Journal Year: 2024, Volume and Issue: 30(1), P. 3 - 4

Published: March 9, 2024

Language: Английский

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Genomic analysis of secondary metabolite biosynthesis gene clusters and structural characterization of terpene synthase and cytochrome P450 enzymes in Zingiber officinale Roscoe

Journal of New Results in Science, Journal Year: 2024, Volume and Issue: 13(2), P. 134 - 152

Published: Aug. 31, 2024

This study uses bioinformatics approaches to elucidate the genetic basis of secondary metabolite biosynthesis in Zingiber officinale (Z. officinale). To this end, it identifies 44 biosynthetic gene clusters and maps onto individual chromosomes, with chromosomes 1A 8A exhibiting higher concentrations. Here, protein homology modeling provided insights into structural characteristics terpene synthases Cytochrome P450 enzymes, shedding light on their potential roles stress response production. Moreover, identification such as (-)-kolavenyl diphosphate synthase TPS28 cytochrome 93A3-like, opens up new possibilities for investigating intricate pathways involved diversity mechanisms within Z. officinale. highlights importance understanding molecular underlying plant-derived bioactive compounds pharmaceutical applications.

Language: Английский

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Simple theranostics nanoagent for precision suppression of tumor growth and Metastasis: A traditional fermented product having a novel functional breakthrough

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 156545 - 156545

Published: Oct. 10, 2024

Language: Английский

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Mechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical studies

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Abstract Chemotherapy (CT) is one of the flagship options for treatment cancers worldwide. It involves use cytotoxic anticancer agents to kill or inhibit proliferation cancer cells. However, despite its clinical efficacy, CT triggers side effect toxicities in several organs, which may impact patient’s quality life and outcomes. While toxicity consistent with non-ferroptotic mechanisms involving oxidative stress, inflammation, mitochondrial impairment other aberrant signalling leading apoptosis necroptosis, recent studies show that ferroptosis, a non-apoptotic, iron-dependent cell death pathway, also involved pathophysiology organ toxicity. provokes ferroptosis via system Xc – /GPX-4/GSH/SLC7A11 axis depletion, ferritinophagy, iron overload, lipid peroxidation upregulation ferritin-related proteins. Cisplatin (CP) doxorubicin (DOX) are common drugs indicated induce vitro vivo. Studies have explored natural preventive therapeutic strategies using ginger rhizome major bioactive compounds, 6-gingerol (6G) zingerone (ZG), combat Ginger extract, 6G ZG mitigate dysfunction toxicity, but their effects on CT-induced remain unclear. Systematic investigations are, therefore, needed unfold roles ginger, as they potential prevention This review reveals ferroptotic protective against CT-induced, toxicities.

Language: Английский

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Are Bentong Ginger (Zingiber officinale) Biosynthesized Silver Nanoparticles Safe and Effective? An Optimization, Characterization, and Toxicity Evaluation Study

OpenNano, Journal Year: 2024, Volume and Issue: unknown, P. 100224 - 100224

Published: Dec. 1, 2024

Language: Английский

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Designing Iron oxide&Silver Nanocomposites With Phyto- and Fungochemicals for Biomedicine: Lessons Learned

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

This work summarises our findings regarding multifunctional complex iron oxide and silver nanoparticles produced with the plants Z. officinale , H. perforatum mushrooms A. muscaria S. crispa .

Language: Английский

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