Apoptosis: Natural Product-Derived Small Molecules as Therapeutics DOI

Srijon Gayen,

Suparna Ghosh, Barun Das Gupta

et al.

Published: Jan. 1, 2024

Language: Английский

Potential anti-gastric cancer properties of modified Lichong decoction based on metabolomics, network pharmacology, and pharmacological verification DOI
Guanglu Shi, Zhe Chen,

Meiyu Feng

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 347, P. 119806 - 119806

Published: April 14, 2025

Language: Английский

Citations

0
Unveiling the gastroprotective effect of the ethyl acetate fraction of Cordia africana Lam. roots against ethanol-induced gastric ulcer and Helicobacter pylori DOI
Engy Mohsen,

Ahlam M. El Fishawy,

Abeer Salama

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 348, P. 119841 - 119841

Published: April 18, 2025

Language: Английский

Citations

0
Aibika Flower Flavonoid Extract Exhibits Antiulcer Activity in a Murine Model of Ethanol-Induced Acute Gastric Injury DOI
Chin‐Feng Hsuan, I‐Ting Tsai, Liwen Fang

et al.

Journal of Medicinal Food, Journal Year: 2024, Volume and Issue: 27(7), P. 615 - 626

Published: May 8, 2024

Aibika (

Language: Английский

Citations

2
Compound Sophorae Decoction mitigates DSS-induced ulcerative colitis by activating autophagy through PI3K-AKT pathway：a integrative research combining network pharmacology and in vivo animal model validation DOI
Yujin Liu,

Shuangjiao Deng,

Lieqian Sun

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118885 - 118885

Published: Oct. 1, 2024

Language: Английский

Citations

2
Peucedanum praeruptorum Dunn leaf aqueous extract protects against alcoholic gastric injury by inhibiting inflammation and oxidative stress in mice DOI
Yulei Zhang,

Yan Li,

Fengxia An

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 335, P. 118628 - 118628

Published: July 24, 2024

Language: Английский

Citations

0
Protective effect of Phlogacanthus thyrsiflorus Nees against experimentally induced gastric mucosal lesions in rats: Experimental evidence from biochemical and histological analysis DOI
Prakash Chandra Gupta, Nisha Sharma, Ashish Kumar Kar

et al.

Journal of Biologically Active Products from Nature, Journal Year: 2024, Volume and Issue: 14(4), P. 427 - 442

Published: July 3, 2024

Language: Английский

Citations

0
Integrating network pharmacology and experimental verification to study the mechanism of Polygonum hydropiper total flavonoids against stress-induced gastric mucosal damage DOI Creative Commons

Bangpei Chen,

Xueqing Huang,

Feifei Zhu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e38629 - e38629

Published: Sept. 30, 2024

Language: Английский

Citations

0
Exploring the potential mechanisms of polysaccharides against gastric ulcer: Network pharmacology analysis and molecular docking validation DOI Creative Commons

Jianhua Huang,

Qi Zou, Ming Hao

et al.

Food Safety and Health, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Gastric ulcer is a common peptic that affects human health and life quality seriously. As anti‐gastric drugs usually cause side‐effects, polysaccharides may be the potential alternatives because of better effectiveness less toxicity. Although activities have been widely reported, mechanisms not yet well‐disclosed. In this study, network pharmacology analysis was performed to explore against gastric ulcer, results were validated by molecular docking. Results indicated β‐glucan, arabinogalactan, xylan, arabinan key structures, ABL1, AKT1, androgen receptor, epidermal growth factor v‐Ha‐ras Harvey rat sarcoma viral oncogene homolog, HSP90AA1, mitogen‐activated protein kinase 8 (MAPK8), MAPK14, NOS2, PIK3R1, RAC1, ras homolog gene family member A, proto‐oncogene tyrosine‐protein Src core targets for in treating ulcer. Polysaccharides influences on 1958 GO items 199 KEGG pathways, their are related MAPK, Ras, PI3K‐Akt, vascular endothelial factor, prolactin, FoxO Rap1 signaling etc. Molecular docking validation showed credible, interactions between polysaccharide structures observed. This study contributes understanding provides references future activity screening mechanism research

Language: Английский

Citations

0
Exploring Xiaojianzhong decoction's potential in gastric cancer treatment: Integrative insights and experimental validation DOI
Chun‐Han Cheng, Wen‐Rui Hao,

Tzu-Hurng Cheng

et al.

World Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 16(12), P. 4553 - 4558

Published: Nov. 8, 2024

Gastric cancer (GC) remains a formidable global health concern with significant morbidity and mortality rates, despite the fact that numerous advances have been made to improve conventional therapies. Xiaojianzhong decoction (XJZ), traditional Chinese medicine, has garnered academic attention as multicomponent, multitarget approach managing GC. The present editorial explores potential of XJZ in treatment GC through comprehensive analysis network pharmacology experimental validation. Network was used identify key molecular targets XJZ, including interleukin 6, prostaglandin-endoperoxide synthase 2, matrix metalloproteinase 9,

Language: Английский

Citations

0
Apoptosis: Natural Product-Derived Small Molecules as Therapeutics DOI

Srijon Gayen,

Suparna Ghosh, Barun Das Gupta

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0