Jujing Formula Protects Retinal by Regulating Nrf2/Ho-1 Pathways and Sphingolipid Rheostat and its Key Protein Levels on Liver-Kidney Yin Deficient Retinal Damage Mice

Published: Jan. 1, 2025

Language: Английский

Integrated transcriptomic and proteomic analyses provide insights into the biosynthesis of Lycii fructus polysaccharides from different cultivation regions

Food Chemistry Molecular Sciences, Journal Year: 2024, Volume and Issue: 10, P. 100232 - 100232

Published: Dec. 5, 2024

Polysaccharides from L. fructus (LFPs) serve as important active biomacromolecules for the wide spectrum of bioactivities exhibited by Lycii fructus. However, influence ecological environments on biosynthesis and structural characteristics LFPs remains largely unexplored. The present research conducted a comprehensive strategy combining physicochemical elucidation, stoichiometric analysis, transcriptomic profiling, proteomic analysis in samples collected typical cultivation regions including Ningxia, Xinjiang, Qinghai. results revealed distinct variations Ningxia compared to those other terms Glc, Ara, GalA composition percentages well overall content. omics data identified 5531 8084 differentially expressed genes (DEGs), 3728 4732 proteins (DEPs) Xinjiang Qinghai respectively. integration analyses enrichment DEGs DEPs involved pathway LFPs, UDPs, AXS, UGDH. Temperature precipitation were significant factors affecting biosynthesis. These provide novel perspective explaining material basis environmental response mechanism underlying quality formation

Language: Английский

Metabolic and molecular basis of flavonoid biosynthesis in Lycii fructus: an integration of metabolomic and transcriptomic analysis

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 255, P. 116653 - 116653

Published: Dec. 25, 2024

Language: Английский