The traditional uses, phytochemistry and pharmacology of Gastrodia elata Blume: A comprehensive review DOI Creative Commons

Yingfeng Zhong,

Jieqing Li, Honggao Liu

et al.

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 106086 - 106086

Published: Dec. 1, 2024

Language: Английский

PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression DOI Creative Commons
Ningning Guo, Xin Wang,

Muran Xu

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107300 - 107300

Published: July 9, 2024

Depression is a serious global mental disorder. Numerous studies have found that depression may be closely related to decreased neurogenesis, neuroinflammation, neurotransmitter imbalance, and synaptic plasticity dysfunction. The pathogenesis of complex involves multiple signal transduction pathways molecular changes. PI3K/AKT pathway an essential signaling in neurons, which widely expressed emotion-related regions the brain. Therefore, play moderating role mood disorders. However, mechanism not been fully described. This review systematically summarized discussed its potential treatment depression. will help development antidepressants.

Language: Английский

Citations

27
Genome-wide identification of carboxyesterase family members reveals the function of GeCXE9 in the catabolism of parishin A in Gastrodia elata DOI

Yaxing Yan,

Mei Jiang,

Xiao Wang

et al.

Plant Cell Reports, Journal Year: 2025, Volume and Issue: 44(2)

Published: Jan. 30, 2025

Language: Английский

Citations

0
Unlocking the neuroprotective secrets of natural products: a focus on the gut-brain axis DOI
Xiliang Yang, Die Hu,

R. Cheng

et al.

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Language: Английский

Citations

0
Parishin A ameliorates cognitive decline by promoting PS1 autophagy in Alzheimer’s disease DOI Creative Commons

Song Guo,

Lilin Yi,

Man Luo

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: March 20, 2025

Introduction Alzheimer’s disease (AD) is a common neurodegenerative in the elderly. Its pathological features include: A lot of misfolding and abnormal aggregation amyloid protein (Aβ); Autophagy disorder, oxidative stress, neuroinflammation, phosphorylated tau synaptic dysfunction. Modern pharmacological studies have found that Paisinhin (PA) has beneficial effects on prevention treatment central nervous system diseases. This study aims to explore role mechanism PA AD through autophagy pathway, lay scientific foundation for development clinical strategies AD. Methods N2A APP cells were treated with different concentrations PA. Cell viability was detected by CCK-8 method. Western blotting expression levels proteins related production, Tau levels. flow transfecting Lc3 double fluorescent plasmid. After Aβ injected into hippocampus WT mice intraperitoneally, learning memory ability tested new object recognition, y maze water maze. The stress level kit. inflammatory factors RT-qpcr. Results not affected at PA, but PS1 significantly decreased 40μM. can obviously improve accumulation AD, some extent save inhibition CQ. Behavioral shown also impairments caused injections. In addition, vivo experiments, levels, inflammation salvage dysfunctions synapses. reduces total . Discussion Our provides first evidence improves Aβ-induced mice. effect appears be mediated promoting reducing stress. It may regulating inflammation, improving abnormally tau, salvaging damaged function, providing valuable insights potential applications

Language: Английский

Citations

0
A comprehensive pharmacology study reveals the molecular mechanisms underlying the antidepressant effects of Gastrodiae Rhizoma DOI
Pei Liu,

Zhihuang Zhao,

Haili Zhang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 142, P. 156761 - 156761

Published: April 19, 2025

Language: Английский

Citations

0
Neuropharmacological effects of Gastrodia elata Blume and its active ingredients DOI Creative Commons
Dong Wang, Wei Liu, Mengmeng Lu

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: April 30, 2025

Gastrodia elata Blume (GE), a traditional Chinese medicine clinically employed to treat neurological disorders, demonstrates therapeutic efficacy supported by robust clinical evidence. Nowadays, conventional pharmacotherapies for conditions-such as cholinesterase inhibitors Alzheimer's or Ldopa Parkinson's-often provide limited symptom relief, exhibit side effects, and fail halt disease w, underscoring the need alternative strategies. The primary bioactive compounds of (GE) include gastrodin, p-hydroxybenzyl alcohol, Vanillyl Polysaccharides, β-sitosterol. Modern research has demonstrated that GE its active components neuropharmacological including neuron protection, reduction neurotoxicity, promotion nerve regeneration survival. For example, Gastrodin, exerts neuroprotection scavenging reactive oxygen species, suppressing pro-inflammatory cytokines, enhancing GABAergic transmission, thereby alleviating oxidative stress neuronal apoptosis. Vanillin, potentiates GABA receptor activity, inhibitory neurotransmission reducing seizure susceptibility.GE polysaccharides modulate gut-brain axis suppress microglial activation, mitigating neuroinflammation. Current studies primarily focus on ingredients treatment diseases such Parkinson's disease, epilepsy, convulsions, depression, schizophrenia, well learning memory, preventing treating cerebral ischemic injury. This review explores effects compounds, elucidates underlying mechanisms, suggests potential preventive strategies using herbal remedies.

Language: Английский

Citations

0
Parishin C modulates the amyloid transformation of alpha-synuclein protein by apparently interacting with the NAC domain DOI

Almas Akhtar,

Payal Singh,

Nikita Admane

et al.

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Journal Year: 2025, Volume and Issue: 1873(4), P. 141076 - 141076

Published: May 8, 2025

Language: Английский

Citations

0
Traditional approaches and recent tools for studying inflammasome activity DOI Creative Commons
Cássio Luiz Coutinho Almeida-da-Silva, Aline Cristina Abreu Moreira-Souza, David M. Ojcius

et al.

Journal of Immunological Methods, Journal Year: 2024, Volume and Issue: 533, P. 113744 - 113744

Published: Aug. 13, 2024

Inflammasomes play a major role in the immune response to infection, development of autoimmune disease, and control cancer. Western blots were originally used early 2000s characterize inflammasome activation. Since then, panoply techniques has been developed visualize activation cells, tissues, animals. This review article describes most common by researchers field proposes that cell-specific characterization tissues or animals may soon be commonly reported.

Language: Английский

Citations

1
Genetic diversity and construction of a core collection in Chinese Gastrodia elata germplasm resources DOI
Mei Yang, Lan Yang,

Jingmin Hai

et al.

Scientia Horticulturae, Journal Year: 2024, Volume and Issue: 337, P. 113595 - 113595

Published: Aug. 29, 2024

Language: Английский

Citations

1
The traditional uses, phytochemistry and pharmacology of Gastrodia elata Blume: A comprehensive review DOI Creative Commons

Yingfeng Zhong,

Jieqing Li, Honggao Liu

et al.

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 106086 - 106086

Published: Dec. 1, 2024

Language: Английский

Citations

0