Association of KRAS Mutation and Gene Pathways in Colorectal Carcinoma: A Transcriptome- and Methylome-Wide Study and Potential Implications for Therapy DOI Open Access
Farzana Jasmine,

Armando Almazan,

Yuliia Khamkevych

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8094 - 8094

Published: July 25, 2024

Kirsten Rat Sarcoma (KRAS) is the most commonly mutated oncogene in colorectal carcinoma (CRC). We have previously reported interactions between microsatellite instability (MSI), DNA promoter methylation, and gene expression. In this study, we looked for associations KRAS mutation, expression, methylation that may help with precision medicine. Genome-wide expression were done paired CRC tumor surrounding healthy tissues. The results suggested (a) magnitude of dysregulation many major pathways was significantly greater patients (b) up- down-regulation these dysregulated could be correlated corresponding hypo- hyper-methylation, (c) up-regulation CDKN2A more pronounced tumors mutation. A recent cell line study showed there higher levels 5-FU-resistant cells down-regulated by Villosol. Our findings suggest possibility a better response to anti-CDKN2A therapy Villosol KRAS-mutant CRC. Also, marked genes proteasome pathway tissue, especially mutation MSI, potential role inhibitor (bortezomib, carfilzomib, or ixazomib) selected if necessary.

Language: Английский

NNMT suppresses H3K9me3 to facilitate malignant progression and drug resistance in gastric cancer DOI
Bo Wang,

Tao Wu

Arab Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Juniperus indica Bertol Extract Combined with 5-Fluorouracil Synergistically Suppresses the Growth of Esophageal Squamous Cell Carcinoma Cells DOI Creative Commons

Hong-Wei Gao,

Kai‐Fu Chang,

Xiao-Fan Huang

et al.

Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(2)

Published: Feb. 1, 2025

Background: Esophageal cancer is a prevalent malignancy of the digestive tract with high incidence rate in Asia. squamous cell carcinoma (ESCC) most common histological type, accounting for more than 90% cases. JIB plant extract Juniperus indica Bertol that has been shown to have anti-proliferation effects nasopharyngeal carcinoma, oral cancer, and melanoma. Objectives: The aim this study was investigate anti-cancer underlying mechanisms action combination 5-FU ESCC cells. Methods: on cytotoxicity, cycle arrest, apoptosis drug resistance development were explored using CE81T/VGH human Results: results showed synergized inhibitory proliferation via downregulating AKT/mTOR pathway cells harboring TP53 exon 8 R273C mutation. treatment induced arrest at G0/G1 S phases mediating levels CDK4/cyclin D1 CDK2/cyclin A. Furthermore, combined effective inducing by activation extrinsic (Fas/caspase-8) intrinsic (Bax/caspase-9) pathways use single drug. Additionally, attenuated long-term culture exhibited enhanced cytotoxicity bile acid environments. Conclusion: synergistically inhibited growth triggered apoptosis. These findings suggest may be potential strategy esophageal cancer.

Language: Английский

Citations

0
Tumor-related factor complement Clq/TNF-related protein 6 affects the development of digestive system tumors through the phosphatidylinositol 3-kinase pathway DOI
Mo-Wei Kong, Xinrui Li, Yu Gao

et al.

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(26), P. 3206 - 3209

Published: July 9, 2024

In this editorial, we review the work of Razali

Language: Английский

Citations

0
Association of KRAS Mutation and Gene Pathways in Colorectal Carcinoma: A Transcriptome- and Methylome-Wide Study and Potential Implications for Therapy DOI Open Access
Farzana Jasmine,

Armando Almazan,

Yuliia Khamkevych

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8094 - 8094

Published: July 25, 2024

Kirsten Rat Sarcoma (KRAS) is the most commonly mutated oncogene in colorectal carcinoma (CRC). We have previously reported interactions between microsatellite instability (MSI), DNA promoter methylation, and gene expression. In this study, we looked for associations KRAS mutation, expression, methylation that may help with precision medicine. Genome-wide expression were done paired CRC tumor surrounding healthy tissues. The results suggested (a) magnitude of dysregulation many major pathways was significantly greater patients (b) up- down-regulation these dysregulated could be correlated corresponding hypo- hyper-methylation, (c) up-regulation CDKN2A more pronounced tumors mutation. A recent cell line study showed there higher levels 5-FU-resistant cells down-regulated by Villosol. Our findings suggest possibility a better response to anti-CDKN2A therapy Villosol KRAS-mutant CRC. Also, marked genes proteasome pathway tissue, especially mutation MSI, potential role inhibitor (bortezomib, carfilzomib, or ixazomib) selected if necessary.

Language: Английский

Citations

0