Machine learning tools for the characterization of bioactive metabolites derived from different parts of Ochrosia elliptica Labill. for the management of Alzheimer's disease

RSC Advances, Journal Year: 2025, Volume and Issue: 15(14), P. 10671 - 10690

Published: Jan. 1, 2025

Ochroisa elliptica revealed 41 compounds using UPLC-MS/MS and assessed their binding affinities to cholinesterase enzymes through molecular docking. A quercetin derivative exhibited the strongest binding. Additionally, dynamic simulations confirmed stable interactions.

Language: Английский

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A comparative analysis using a forest resource Opuntia ficus-indica L. (prickly pear) and Pyrus communis (common pear) a commercial fruit: Implications on nutrition and sustainability.

Journal of Agriculture and Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 101892 - 101892

Published: April 1, 2025

Language: Английский

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Brine Shrimp Bioactivity and Cytotoxic Potential of Irvingia gabonensis (Aubry-Lecomte ex O’Rorke) Baill Seed

Jundishapur journal of health sciences, Journal Year: 2024, Volume and Issue: 16(1)

Published: March 24, 2024

Background: The seed of Irvingia gabonensis is recognized for its potential bioactivity and medicinal benefits, yet cytotoxicity chemical composition have not been fully investigated. Objectives: This study aimed to evaluate the ethanol extract ethyl acetate fraction using brine shrimp as a model organism. Methods: was prepared through maceration Soxhlet extractor, followed by derivation fraction. both extracts were assessed lethality assay, with lethal concentration 50% (LC50) values calculated gauge cytotoxicity. tested against determine their LC50 cell viability also evaluated. Cyclophosphamide served reference compound comparative purposes. Results: Both derivative showed moderate shrimp, 93.22 ± 0.03 μg/mL 190.80 μg/mL, respectively. Importantly, exhibited higher compared fraction, derivatives being comparable that cyclophosphamide. Conclusions: These findings indicate demonstrates considerable underscoring sources bioactive compounds therapeutic use.

Language: Английский

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Histopathological and Biochemical Effects of Methanol and Aqueous Extracts of the Leaf of Irvingia gabonensis (African Wild Mango) on the Liver of Albino Wistar Rat

SSRN Electronic Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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Therapeutic effects of Irvingia gabonensis extracts in mitigating lead-induced reproductive damage in male Wistar rats: Restoration of hormonal and oxidative markers

Journal of Pharmacy and Allied Medicine, Journal Year: 2024, Volume and Issue: 2(2), P. 46 - 60

Published: Dec. 27, 2024

Language: Английский

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