The role of MAPK pathway in gastric cancer: unveiling molecular crosstalk and therapeutic prospects DOI Creative Commons
Weiwei Yuan, Shi Yin,

Shiping Dai

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 24, 2024

Gastric cancer remains a significant health burden globally, especially prevalent in Asian and European regions. Despite notable decline incidence the United States Western Europe over recent decades, disease's persistence underscores urgency for advanced research its pathogenesis treatment strategies. Central to this pursuit is exploration of mitogen-activated protein kinase (MAPK) pathway, pivotal cellular mechanism implicated complex processes gastric development, including proliferation, invasion, migration, metastasis. The MAPK or extracellular signal-regulated pathway serves as crucial conduit transmitting signals elicit intracellular responses, with signaling cascades subject alterations due genetic epigenetic variations across various diseases, prominently cancer. This review delves into intricate role cancer, drawing upon most critical studies that shed light on gateway disease. It highlights pathway's involvement Helicobacter pylori-mediated carcinogenesis tumorigenic induced by Epstein-Barr virus, showcasing substantial influence miRNAs lncRNAs modulating cancer's biological properties through their interaction pathway. Furthermore, extends therapeutic arena, discussing promising impacts herbal medicines, inhibitors, immunosuppressants mitigating progression. Through an exhaustive examination multifaceted from molecular crosstalks prospects, aspires contribute ongoing efforts understanding combating global challenge, paving way novel interventions improved patient outcomes.

Language: Английский

Multi-omics analysis combined with network pharmacology revealed the mechanisms of rutaecarpine in chronic atrophic gastritis. DOI
Lisheng Chen, Lei Chang, Wenbin Wu

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 119151 - 119151

Published: Nov. 1, 2024

Language: Английский

Citations

4
Isoferulic Acid Inhibits Proliferation and Migration of Pancreatic Cancer Cells, and Promotes the Apoptosis of Pancreatic Cancer Cells in a Mitochondria‐Dependent Manner Through Inhibiting NF‐κB Signalling Pathway DOI Open Access

Suqin Sun,

Rong Fan, Chang Li

et al.

Clinical and Experimental Pharmacology and Physiology, Journal Year: 2025, Volume and Issue: 52(3)

Published: Jan. 24, 2025

ABSTRACT Isoferulic acid (IA), a derivative of cinnamic acid, is derived from Danshen and exhibits anticancer properties by disrupting cancer cell activities. However, its role in pancreatic cancer, the “king cancer”, was unknown. In this study, cells were subjected to treatment with IA (6.25, 12.5, 25 μM), nude mice injected received at doses 7.5 mg/kg/day or 30 oral administration. CCK8, Annexin V‐FITC/propidium iodide (PI) double staining TUNEL assay conducted evaluate viability apoptosis. Hoechst comet employed measure DNA damage. Mitochondrial membrane potential (MMP) analysis carried out explain mitochondrial EdU wound healing performed for proliferation migration detection. Immunofluorescence western blot used explore mechanism. We found that reduced induced apoptosis, as evidenced an increase V‐FITC + PI − populations, brighter staining, more percentage tail DNA. Furthermore, decreased MMP changed levels apoptosis‐related proteins. The inhibited treatment. Mechanically, downregulated phosphorylation IĸBα p65 nuclear translocation, consequently suppressing NF‐κB pathway. general, suppressed migration, caused apoptosis mitochondria‐dependent manner through blocking signalling pathway, indicating may be therapeutic strategy cancer.

Language: Английский

Citations

0
Aconiti Lateralis Radix Praeparata ameliorates heart failure via PI3K/AKT/Bnip3 pathway DOI Creative Commons
Wenxiu Liu,

Xingju Zou,

Yang Zheng

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Background Chronic heart failure (CHF) is one of the leading causes high mortality worldwide. It characterized by pathological hypertrophy and poses a major threat to human health. Aconiti Lateralis Radix Praeparata widely used in ancient China treat CHF. However, pathology obscured, necessitating further exploration. Methods Prospective targets were predicted network analysis. A transverse aortic constriction (TAC) mice model was subsequently constructed determine effects aqueous extract (AEA) on The echocardiography performed investigate cardiac function. Histopathological analysis tissue conducted assess myocardial fibrosis. Nontargeted metabolomics analyze serum metabolites. phosphorylation level PI3K AKT, downstream such as Bnip3, p62, Atg5, LC3II measured Western blotting. In vitro , norepinephrine (NE) stimulate hypertrophy. Parameters reactive oxygen species levels, mitochondrial membrane potential, ATP concentration, CK/MB content detected H9c2 cells. Results AEA significantly alleviated Network indicated participation AKT CHF, modulated Praeparata. vivo administration effectively ameliorated performance, evidenced elevation ejection fraction. displayed diminishment collagen fiber. Metabolomics showed that several metabolites tetrahydroxycorticosterone, decylubiquinone taurocholic acid increased TAC serum. Additionally, levels expression Drp1, Opa1, Atg5 altered group. NE stimulation cell surface area deteriorated functions partially reversed results, mechanism associated with mitophagy. Conclusion This study revealed improved function via PI3K/AKT/Bnip3 pathway.

Language: Английский

Citations

0
Proteomic Analysis Identifies Multiple Mechanisms of 5-Fluorouracil-Induced Gut Mucositis in Mice DOI Open Access
Sergey M. Ivanov, Victor G. Zgoda,

Valeria A. Isakova

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(23), P. 4025 - 4025

Published: Nov. 30, 2024

Damage of the gastrointestinal mucosa is a major side effect anticancer drug 5-fluorouracil (5-FU). Insight into molecular pathogenesis 5-FU-induced gut mucositis expected to justify strategies prophylaxis.

Language: Английский

Citations

1
The role of MAPK pathway in gastric cancer: unveiling molecular crosstalk and therapeutic prospects DOI Creative Commons
Weiwei Yuan, Shi Yin,

Shiping Dai

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 24, 2024

Gastric cancer remains a significant health burden globally, especially prevalent in Asian and European regions. Despite notable decline incidence the United States Western Europe over recent decades, disease's persistence underscores urgency for advanced research its pathogenesis treatment strategies. Central to this pursuit is exploration of mitogen-activated protein kinase (MAPK) pathway, pivotal cellular mechanism implicated complex processes gastric development, including proliferation, invasion, migration, metastasis. The MAPK or extracellular signal-regulated pathway serves as crucial conduit transmitting signals elicit intracellular responses, with signaling cascades subject alterations due genetic epigenetic variations across various diseases, prominently cancer. This review delves into intricate role cancer, drawing upon most critical studies that shed light on gateway disease. It highlights pathway's involvement Helicobacter pylori-mediated carcinogenesis tumorigenic induced by Epstein-Barr virus, showcasing substantial influence miRNAs lncRNAs modulating cancer's biological properties through their interaction pathway. Furthermore, extends therapeutic arena, discussing promising impacts herbal medicines, inhibitors, immunosuppressants mitigating progression. Through an exhaustive examination multifaceted from molecular crosstalks prospects, aspires contribute ongoing efforts understanding combating global challenge, paving way novel interventions improved patient outcomes.

Language: Английский

Citations

1