Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1354 - 1354

Published: Oct. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Language: Английский

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Potential of Chlorogenic Acid in the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Animal Studies and Clinical Trials—A Narrative Review

Metabolites, Journal Year: 2024, Volume and Issue: 14(6), P. 346 - 346

Published: June 20, 2024

Chlorogenic acid (CGA) is a natural polyphenol found in coffee, tea, vegetables, and fruits. It exhibits strong antioxidant activity possesses several other biological properties, including anti-inflammatory effects, antimicrobial activity, insulin-sensitizing properties. Moreover, it may improve lipid glucose metabolism. This review summarizes the available information on therapeutic effect of CGA metabolic dysfunction-associated steatotic liver disease (MASLD). As literature search engine, browsers PubMed, Scopus, Web Science databases, ClinicalTrials.gov register were used. Animal trials clinical studies suggest that has promising potential treating MASLD hepatic steatosis. Its mechanisms action include antioxidant, anti-inflammatory, anti-apoptotic effects via activation Nrf2 signaling pathway inhibition TLR4/NF-κB cascade. Furthermore, alleviation by also involves important molecules such as AMPK physiological processes intestinal barrier gut microbiota. Nevertheless, specific target cell key molecule to which directed remain unidentified require further study.

Language: Английский

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Pandanus Amaryllifolius Roxb. Polyphenol Extract Alleviates NAFLD via Regulating Gut Microbiota and AMPK/AKT/mTOR Signaling Pathway

Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 1000 - 1000

Published: March 15, 2025

With the drastic changes in lifestyle, nonalcoholic fatty liver disease (NAFLD) has become a widespread health problem. Natural actives such as polyphenols have multi-target, multi-mechanism characteristics, and offer new opportunities for NAFLD treatment. This study established high-fat diet (HFD)-induced model mice to investigate molecular mechanism of Pandanus amaryllifolius Roxb. polyphenol extract (PAE) alleviating NAFLD. The results showed that PAE significantly inhibited HFD-induced obesity, maintained glucose homeostasis, mitigated oxidative damage tissue, reduced steatosis. Moreover, treatment remarkably reversed 16 endogenous DMs, affected glycerophospholipid metabolism, which increased levels phosphatidylcholine phosphatidylethanolamine, down-regulated choline sn-glyceropl-3P. Further validation revealed was able prevent progression by regulating AMPK/AKT/mTOR signaling pathway enhance autophagy levels. Meanwhile, restored balance gut microbiota mainly increasing relative abundance Bacteroidetes, decreasing Firmicutes ratio Firmicutes/Bacteroidetes. Overall, findings highlight alleviates may be related regulation microbes pathway, enriching health-promoting effects on

Language: Английский

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The Gene SiPrx from Saussurea involucrata Enhances the Stress Resistance of Silphium perfoliatum L.

Plants, Journal Year: 2025, Volume and Issue: 14(7), P. 1030 - 1030

Published: March 26, 2025

Peroxiredoxin (Prx) plays a role in maintaining the balance of intracellular reactive oxygen species. The peroxidase SiPrx gene from Tianshan Snow Lotus (Saussurea involucrata) has been proved to significantly enhance stress resistance plants. In this study, was expressed heterogeneously high-quality herbage Silphium perfoliatum L. (SP). After treatment with NaCl, transgenic SP only exhibited partial leaf wilting, whereas wild-type (WT) plants were on brink death. Simultaneously, physiological and biochemical assays indicated that under high-salt conditions, content malondialdehyde lower than WT plants, while activity antioxidant enzymes higher expression shown salt SP. Furthermore, after at -10 °C for 48 h, leaves able maintain certain morphological structure, completely wilted. Physiological index measurements all indicators better those Based these findings, study plans overexpress extracted Saussurea involucrata Comfrey using Agrobacterium-mediated method then its effects research results indicate shows significant application potential enhancing cold tolerance This provides basis scientific evidence mining genes cultivation new varieties

Language: Английский

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Seabuckthorn polysaccharides mitigate hepatic steatosis by modulating the Nrf-2/HO-1 pathway and gut microbiota

AMB Express, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 9, 2024

Language: Английский

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Platycodon D reduces obesity and non-alcoholic fatty liver disease induced by a high-fat diet through inhibiting intestinal fat absorption

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 17, 2024

Background Platycodin D (PD) has been reported to treat metabolic diseases, including non-alcoholic fatty liver disease. In addition, platycodin activate intestinal 5'AMP-activated protein kinase (AMPK) phosphorylation levels, thereby reducing lipid absorption. Therefore, the aim of this study is explore whether PD activation AMPK and reduced absorption can improve Methods Clean-grade male C57/BL mice were fed a high-fat diet (HFD) (containing 60% calories) for 16 weeks, oral (10 mg/kg/day) was administered at same time. The intestines collected, tested. expressions genes (CD36, NPC1L1, ApoB), serum total triglyceride (TG) cholesterol (TC) levels in livers, fecal free acid (FFA) expression phosphorylated proteins examined using Western blot analyses. distribution intestines, fat detected Oil Red O hematoxylin eosin (H&E) staining. A colon cancer cell line (Caco2) used confirm effect on cellular uptake vitro . inflammatory factors enzymes measured clarify impact circulation syndrome. Leptin-deficient (OB) then further improvement body weight blood lipids. Results had very significant therapeutic or preventive syndrome induced by diet. improved weight, insulin sensitivity, glucose tolerance also prevented disease, increased excretion. activating protein, which may have involved inhibition gene ApoB). combined these hepatic accumulation adipose tissue. It found that weights leptin-deficient mice. Conclusion strong under diet-induced obesity disease inhibiting

Language: Английский

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Caffeoylquinic acids from Silphium perfoliatum L. show hepatoprotective effects on cholestatic mice by regulating enterohepatic circulation of bile acids

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 337, P. 118870 - 118870

Published: Sept. 30, 2024

Language: Английский

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Investigation of Active Components of Meconopsis integrifolia (Maxim.) Franch in Mitigating Non-Alcoholic Fatty Liver Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 50 - 50

Published: Dec. 24, 2024

Nonalcoholic fatty liver disease (NAFLD) has rapidly emerged as the most prevalent chronic globally, representing a significant and escalating public health challenge. Meconopsis integrifolia (Maxim.) Franch, traditional Tibetan medicinal herb used for treating hepatitis, remains largely unexplored regarding its therapeutic potential active components in combating NAFLD. This study first evaluated vitro lipid accumulation inhibitory activity of different extraction fractions M. using HepG2 cell steatosis model. The ethyl acetate fraction was found to significantly reduce triglyceride (TG) low-density lipoprotein (LDL) levels, inhibit droplet deposition cells, promote metabolism balance through modulation AMPK/SREPB-1c/PPAR-α signaling pathway. Further analysis utilizing chromatographic techniques nuclear magnetic resonance spectroscopy (NMR) led isolation 13 compounds from fraction. Notably, 6, 9, 10, 11, 12, were identified time this herb. In assays molecular docking analyses further confirmed that Luteolin (1), Quercetin 3-O-[2‴, 6‴-O-diacetyl-β-d-glucopyranosyl-(1→6)-β-d-glucopyranoside] (6), 3-O-[2‴-O-acetyl-β-d-glucopyranosyl-(1→6)-β-d-glucopyranoside] (8) are key responsible NAFLD-ameliorating effects integrifolia. highlights NAFLD provides foundation development application, underscoring significance advanced utilization medicine.

Language: Английский

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