Advances in omics technologies for traditional Chinese medicine in the prevention and treatment of metabolic bone diseases

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 11, 2025

Metabolic bone disease (MBD), as one of the most severe metabolic disorders, remains a focal point and challenge in medical research. Numerous studies have demonstrated efficacy Traditional Chinese Medicine (TCM) preventing treating MBD. However, inherent complexity TCM metabolites poses significant limitations elucidating their mechanisms action. The advancement omics technologies, including metabolomics, proteomics, transcriptomics, has greatly facilitated research on These approaches enable identification potential biomarkers exploration pathways underlying interventions for Evidence indicates that monomers, single botanical drugs, herbal formulations are effective, safe, well-tolerated MBD prevention treatment. This review summarizes recent applications key findings metabolomics studying It highlights role technologies uncovering relevant under treatment, providing valuable insights clinical references TCM-based strategies managing

Language: Английский

From gut to bone: deciphering the impact of gut microbiota on osteoporosis pathogenesis and management

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 25, 2024

Osteoporosis (OP) is characterized by decreased bone mineral density (BMD) and increased fracture risk, poses a significant global health burden. Recent research has shed light on the bidirectional relationship between gut microbiota (GM) health, presenting novel avenue for understanding OP pathogenesis developing targeted therapeutic interventions. This review provides comprehensive overview of GM-bone axis, exploring impact GM development management. We elucidate established risk factors OP, delve into diversity functional changes in OP. Furthermore, we examine experimental evidence clinical observations linking alterations composition or function with variations BMD risk. Mechanistic insights microbial mediators such as metabolites products, are discussed. Therapeutic implications, including GM-targeted interventions dietary strategies, also explored. Finally, identify future directions challenges translating these findings practice.

Language: Английский

Recent discoveries of oral substances’ effects on osteoporosis treatment - novel markers and pathways

Quality in Sport, Journal Year: 2024, Volume and Issue: 19, P. 54329 - 54329

Published: Aug. 30, 2024

The search for optimal osteoporosis treatments continues, as the medications currently used in clinical therapy carry a risk of rare but acute side effects. New knowledge about etiopathogenetic pathways and biomarkers enabled exact examination various oral substances, often previously recognised their positive impact on bone mass growth. A cross-section novel reports from this year applications many orally administered substances is presented. Diet, gut microbiota aspect, functional food, diabetes drug – empagliflozin variety known Chinese traditional medicine are now characterized context possible mechanism treating or preventing osteoporosis. progress density quality-regulating recognition led to finding multiple with favorable mediation properties. precise diagnosis substances' working mechanisms approves potential use new formulations treatments. Presently only diet supplementation, administrated antiosteoporotic core ingredients modernized medications, provided presumptive adverse effects ruled out.

Language: Английский