Traditionally used edible medicinal plants protect against rotenone induced toxicity in SH-SY5Y cells- a prospect for the development of herbal nutraceuticals. DOI
Aruna Chanu Hijam,

Yaiphabi Chanu Tongbram,

Pooja Devi Nongthombam

et al.

Neurochemistry International, Journal Year: 2024, Volume and Issue: 180, P. 105855 - 105855

Published: Sept. 6, 2024

Language: Английский

Natural Products and Their Neuroprotective Effects in Degenerative Brain Diseases: A Comprehensive Review DOI Open Access
Dong Wook Lim,

Jung‐Eun Lee,

Chang-Ho Lee

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11223 - 11223

Published: Oct. 18, 2024

As the global population ages, incidence of neurodegenerative diseases such as Alzheimer’s and Parkinson’s is rapidly rising. These present a significant public health challenge, they severely impair cognitive motor functions, ultimately leading to substantial reduction in quality life placing heavy burden on healthcare systems worldwide. Although several therapeutic agents have been developed manage symptoms these diseases, their effectiveness often limited, there remains an urgent need for preventive strategies. Growing evidence indicates that bioactive compounds from natural products possess neuroprotective properties through antioxidant anti-inflammatory effects, modulating key pathways phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) brain-derived neurotrophic factor–tropomyosin receptor B–cAMP response element-binding protein (BDNF-TrkB-CREB), which are crucial neuronal survival. may also reduce amyloid-beta tau pathology, well enhance cholinergic neurotransmission by inhibiting acetylcholinesterase activity. By targeting oxidative stress, neuroinflammation, neurodegeneration, offer promising approach both prevention treatment. findings suggest be preventing treating diseases. This review aims explore pathogenesis limitations current therapies, potential role agents.

Language: Английский

Citations

8
In vivo and in vitro anti-inflammatory activity of the methanolic leaves extract of Gymnopodium floribundum Rolfe DOI

Fernando Ramos Torre,

Edwin Alejandro Tec Caamal,

Abril Bernardette Martínez-Rizo

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 347, P. 119743 - 119743

Published: April 9, 2025

Language: Английский

Citations

0
Traditionally used edible medicinal plants protect against rotenone induced toxicity in SH-SY5Y cells- a prospect for the development of herbal nutraceuticals. DOI
Aruna Chanu Hijam,

Yaiphabi Chanu Tongbram,

Pooja Devi Nongthombam

et al.

Neurochemistry International, Journal Year: 2024, Volume and Issue: 180, P. 105855 - 105855

Published: Sept. 6, 2024

Language: Английский

Citations

0