Hydroxy-α-sanshool-loaded adipose-targeted mesoporous silica nanoparticles induce white adipose browning and reduce obesity by activating TRPV1

Bio-Design and Manufacturing, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Development and optimization of the Glabridin-loaded dissolving microneedle for enhanced treatment of keloid

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 8, P. 100267 - 100267

Published: July 1, 2024

Glabridin (Gla) has been reported to have significant effects in scar treatment, and however, the water insolubility of Gla leads its poor transdermal absorption ability, which affects bioactivities. Therefore, we attempted prepare dissolving microneedles (Gla-MN) improve absorbtion Gla. After investigation 3 factors including needle tip matrix concentration, prescription concentration backing material, dissolution method Gla, finally determined process parameters 10% hyaluronic acid (HA) as 5% polyvinyl alcohol (PVA) backing, according Gla-MN was prepared with good characteristics high hardness, complete appearance vitro ability. We then loaded onto measured that average drug loading 2.26 ± 0.11 μg/mg cumulative release up 76.9% after 24 h. In addition, had skin penetration properties, penetrating at least 4 5 layers parafilm. And basically could return normal h piercing. Importantly, our results showed higher delivery therapeutic against keloid than same dosage.

Language: Английский

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Targeting IL-17 and its receptors: A feasible way for natural herbal medicines to modulate fibroblast-like synoviocytes in rheumatoid arthritis

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 116598 - 116598

Published: Oct. 1, 2024

Language: Английский

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Research progress on the natural products in the intervention of myocardial infarction

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 22, 2024

Coronary heart disease is a prevalent cardiovascular ailment globally, with myocardial infarction (MI) being one of its most severe manifestations. The morbidity and mortality MI are escalating, showing an increasing trend among younger, highly educated individuals, thereby posing serious threat to public health. Currently, thrombolysis, percutaneous coronary intervention, artery bypass grafting the primary clinical treatments for MI. Although these methods significantly reduce patient mortality, complications often result in poor prognoses. Due limitations chemical synthetic drug research, focus has shifted towards developing herbs based on natural substances. Natural medicines represent novel approach safer more effective management treatment. They can control multiple pathogenic variables by targeting various pathways systems. This paper investigates molecular mechanisms evaluates application products medicinal plants treatment over past 5 years, demonstrating their specific good therapeutic potential superior tolerance. These therapies have been shown mitigate cell damage caused through such as oxidative stress, inflammation, apoptosis, angiogenesis, fibrosis, autophagy, endoplasmic reticulum mitophagy, pyroptosis. review offers latest insights into treatment, elucidating action serving important reference prevention.

Language: Английский

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Effects of herbal wet compresses on pain intensity, inflammatory factor levels, and quality of life in patients with pain

American Journal of Translational Research, Journal Year: 2024, Volume and Issue: 16(9), P. 4728 - 4740

Published: Jan. 1, 2024

To investigate the pharmacological mechanisms and clinical effects of Traditional Chinese Medicine (TCM) wet compresses on pain, inflammation, quality life in patients with soft tissue injuries.

Language: Английский

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