Coagulation factor II thrombin receptor as a promising biomarker in breast cancer management DOI Creative Commons
Yanming Dong, Guo‐Qiang Bao

Open Life Sciences, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 1, 2024

Abstract This study aims to comprehensively investigate the role of coagulation factor II thrombin receptor (F2R) in breast cancer (BC) and evaluate its potential as a biomarker this context. Data on female BC were retrieved from TCGA database. Comparative analyses performed, including enrichment analysis, tumor immune microenvironment drug sensitivity testing, molecular docking, cell-based experiments, assess expression function F2R BC. Statistical graphical representations conducted using R software. The confirmed significant upregulation BC, which was associated with more favorable prognosis. Clinical correlation analysis revealed strong association between key clinical parameters, such estrogen progesterone status. Additionally, genes co-expressed significantly linked various biological processes, cell cycle regulation, oxidative phosphorylation, ribosomal function, extracellular matrix interactions. also showed associations modulators, particularly CD200 NRP1. Drug experiments consistently demonstrated positive correlations dasatinib. underscores valuable providing insights into mechanisms underlying tumorigenesis.

Language: Английский

Targeted modulation of myeloid-derived suppressor cells in the tumor microenvironment: Implications for cancer therapy DOI Open Access

Yafeng Qi,

Liying Zhang,

Y Q Liu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117590 - 117590

Published: Oct. 17, 2024

Language: Английский

Citations

10
Influence of gut microbial metabolites on tumor immunotherapy: mechanisms and potential natural products DOI Creative Commons
Dongyang Li, Xingguo Lan,

Linyi Xu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

In recent years, tumor immunotherapy has made significant breakthroughs in the treatment of malignant tumors. However, individual differences efficacy have been observed clinical practice. There is increasing evidence that gut microbial metabolites influence distal via gut-liver axis, gut-brain axis and gut-breast a process may involve modulating expression immune cells cytokines microenvironment (TME). this review, we systematically explore relationship between immunotherapy, examine corresponding natural products their mechanisms action. The in-depth exploration research area will provide new ideas strategies to enhance mitigate adverse effects.

Language: Английский

Citations

0
Metabolomics, E-tongue and HS-SPME-GC–MS reveal the smoking process of Prunus mume: Changes in flavor and chemical compositions DOI

Yun-yi Hu,

Jingpeng Liao,

Wen-zhang Qian

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 484, P. 144401 - 144401

Published: April 18, 2025

Language: Английский

Citations

0
Qingjie Fuzheng Granule prevents colitis-associated colorectal cancer by inhibiting abnormal activation of NOD2/NF-κB signaling pathway mediated by gut microbiota disorder DOI Open Access
Bin Huang,

Honglin An,

Mengxuan Gui

et al.

Chinese Herbal Medicines, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Determination of Multiple Active Components in Mume Fructus by UPLC-MS/MS DOI Creative Commons
Nannan Li, Jingyi Yue,

Rui Wang

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(5), P. 312 - 312

Published: May 6, 2025

Background: This study presents a sensitive method for the simultaneous determination of organic acids, flavonoids, and amino acids in Mume Fructus (MF) using ultra-performance liquid chromatography coupled with triple-quadrupole linear ion-trap tandem mass spectrometry (UPLC-QTRAP-MS/MS). Methods: Analysis was performed on UPLC system (Shimadzu, Kyoto, Japan) equipped quaternary pump solvent management system, an online degasser, detector, autosampler. An Agilent ZORBAX SB-C18 column (3.0 mm × 100 mm, 1.8 µm) used chromatographic analyses. The mobile phase distributed between 0.2% aqueous formic acid (A) acetonitrile (B) at velocity 0.2 mL/min. gradient evolution protocol 0–2 min 90–70% B; 3–7 70–50% 7–10 50–20% 10–14.5 20–90% 14.5–17 10% B. Results: validated matrix effects, linearity, limits detection/quantification, precision, repeatability, stability, recovery target components. It effectively determined all compounds 12 MF batches from different drying methods. Conclusions: Principal component analysis (PCA) 47 active components conducted to evaluate quality comprehensively. proposed serves as reliable approach assessing consistency MF’s therapeutic efficacy.

Language: Английский

Citations

0
Research progress of DNA methylation in colorectal cancer (Review) DOI

Yuxin Wang,

Chengcheng Wang, Ruiqi Zhong

et al.

Molecular Medicine Reports, Journal Year: 2024, Volume and Issue: 30(3)

Published: July 3, 2024

DNA methylation is one of the earliest and most significant epigenetic mechanisms discovered. refers, in general, to addition a methyl group specific base sequence under catalysis methyltransferase, with S‑adenosine methionine as donor, via covalent bonding chemical modifications. an important factor inducing cancer. There are different types methylation, at sites plays roles. It well known that progression colorectal cancer (CRC) affected by key genes. The present review did not only discuss potential relationship between CRC but also discussed how affects development affecting Furthermore, clinical significance was highlighted, including therapeutic targets biomarkers methylation; importance inhibitors novel strategy for treatment CRC. focus upon latest research findings, earlier reviews were cited references older literature.

Language: Английский

Citations

3
Traditional Chinese Medicine Formulas-Based Interventions on Colorectal Carcinoma Prevention: The Efficacies, Mechanisms and Advantages DOI Creative Commons

Xiaojuan Tang,

He Min,

Yuan Ren

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 119008 - 119008

Published: Oct. 1, 2024

Language: Английский

Citations

2
Emerging role of small RNAs in inflammatory bowel disease and associated colorectal cancer (Review) DOI Creative Commons
Wei Qiu,

Francis Atim Akanyibah,

Yuxuan Xia

et al.

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 55(2)

Published: Dec. 18, 2024

Inflammatory bowel diseases (IBDs), which encompasses Crohn's disease and ulcerative colitis, is a chronic inflammatory condition associated with an increased risk of colorectal cancer (CRC). Small RNAs have been linked to various illnesses, including IBD CRC. These small also serve as potential biomarkers for these diseases, offering cutting‑edge approach investigating possible treatments. To date, treatments involving oral nucleic acid usage are still unachievable due the instability medications in gastrointestinal tract (GIT), their lack ability effectively target tissues notable adverse effects. However, nanoparticle or exosome delivery systems by overcoming GIT, resulting effective outcome. In present review, biogenesis (tRNA‑derived RNA, microRNA, nucleolar RNA p‑element‑induced wimpy testis‑interacting RNA), roles pathogenesis CRC well application diagnostic prognostic discussed.

Language: Английский

Citations

2
Coagulation factor II thrombin receptor as a promising biomarker in breast cancer management DOI Creative Commons
Yanming Dong, Guo‐Qiang Bao

Open Life Sciences, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 1, 2024

Abstract This study aims to comprehensively investigate the role of coagulation factor II thrombin receptor (F2R) in breast cancer (BC) and evaluate its potential as a biomarker this context. Data on female BC were retrieved from TCGA database. Comparative analyses performed, including enrichment analysis, tumor immune microenvironment drug sensitivity testing, molecular docking, cell-based experiments, assess expression function F2R BC. Statistical graphical representations conducted using R software. The confirmed significant upregulation BC, which was associated with more favorable prognosis. Clinical correlation analysis revealed strong association between key clinical parameters, such estrogen progesterone status. Additionally, genes co-expressed significantly linked various biological processes, cell cycle regulation, oxidative phosphorylation, ribosomal function, extracellular matrix interactions. also showed associations modulators, particularly CD200 NRP1. Drug experiments consistently demonstrated positive correlations dasatinib. underscores valuable providing insights into mechanisms underlying tumorigenesis.

Language: Английский

Citations

0