Tong-Qiao-Huo-Xue Decoction Promotes Synaptic Remodeling via cAMP/PKA/CREB Pathway in Vascular Dementia Rats DOI Creative Commons
Jiacheng Li, Haiyong Ye, Fan Xu

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156166 - 156166

Published: Oct. 19, 2024

Language: Английский

Nobiletin: a potential erythropoietin receptor activator protects renal cells against hypoxia DOI Creative Commons
Na Liu,

Yuzhuo Sun,

Jieyun Liu

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Language: Английский

Citations

1
Jiawei Kongsheng Zhenzhong Pill (JKZP) Alleviates Chronic Cerebral Hypoperfusion‐Induced Hippocampal Synaptic Damage via S100A10/tPA/BDNF Pathway DOI Creative Commons

Qiaolan Wu,

Yang Zhou,

Chunxue Ou

et al.

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 1, 2025

ABSTRACT Aims To evaluate the effects of Jiawei Kongsheng Zhenzhong Pill (JKZP) on rats with ischemic mild cognitive impairment (MCI) and investigate underlying mechanisms. Methods The components JKZP were analyzed using Q‐Orbitrap high‐resolution mass spectrometry (HRMS). MCI rat model was prepared through gradual bilateral common carotid artery occlusion (BCCAO). function, hippocampal pathological lesions, dendritic spine damage, synapse‐related, S100 calcium‐binding protein A10 (S100A10)/tissue‐type plasminogen activator (tPA)/brain‐derived neurotrophic factor (BDNF) pathway‐associated molecules alterations measured. Primary hippocampus neurons subjected to oxygen‐glucose deprivation/reperfusion (OGD/R) injury, JKZP‐containing serum utilized for treatment. Lentiviral‐infected constructed S100A10 knockdown RNAi technology whether exerted its anti‐MCI via S100A10/tPA/BDNF pathway. Results A total 64 major components, including β‐asarone, ferulic acid, loganin, senkyunolide H, cryptotanshinone, identified by HRMS technology. had a notable impact enhancing abilities MCI. reduced damage CA1 region neuron synaptic structure, reversed decrease in spines, increased expressions synapse‐associated proteins such as synaptophysin (SYN), growth‐associated 43 (GAP43), postsynaptic density 95 (PSD95). Furthermore, treatment dramatically ratio BDNF (proBDNF)/mature (mBDNF) activating S100A10/tPA, which confirmed primary vitro. Moreover, sh‐S100A10 tremendously mitigated inhibitory action OGD/R‐mediated synapse decreased activity tPA, thus improved downstream pathway targets’ ratio, proBDNF/mBDNF. Conclusions These results manifested that promoted neurological recovery after chronic cerebral ischemia alleviating pathway, thereby providing novel perspective solid foundation against

Language: Английский

Citations

0
Ditan Decoction ameliorates vascular dementia-induced cognitive dysfunction through anti-ferroptosis via the HIF1α pathway: Integrating network pharmacology and experimental validation DOI
Meiyuan Gu,

Lieqian Sun,

Jie Yang

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119459 - 119459

Published: Feb. 1, 2025

Language: Английский

Citations

0
Effects of anxiety induced by conditioned fear on the expression of NMDA receptors and synaptic plasticity in the rat BLA DOI

Yue-Heng Yan,

Hongkun Wang, Zihao Wang

et al.

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 115547 - 115547

Published: March 1, 2025

Language: Английский

Citations

0
Tong-Qiao-Huo-Xue Decoction Promotes Synaptic Remodeling via cAMP/PKA/CREB Pathway in Vascular Dementia Rats DOI Creative Commons
Jiacheng Li, Haiyong Ye, Fan Xu

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156166 - 156166

Published: Oct. 19, 2024

Language: Английский

Citations

2