Sevoflurane anesthesia during late gestation induces cognitive disorder in rat offspring via the TLR4/BDNF/TrkB/CREB pathway DOI
Qianqian Li, Yu Qi, Zhiyi Liu

et al.

Journal of Neuropathology & Experimental Neurology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 22, 2024

Abstract Sevoflurane (Sevo) is widely used for general anesthesia during pregnancy. Emerging evidence indicates that maternal Sevo exposure can trigger developmental neurotoxicity in the offspring. Nonetheless, underlying mechanisms need further investigation. Pregnant Sprague-Dawley rats on gestational day 18 were exposed to 3.5% induce rat model of neurotoxicity. TAK-242, a TLR4 inhibitor, was administrated inhibit signaling transduction. Hippocampal tissues offspring harvested immunohistochemical staining, TUNEL Western blotting, ELISA, and measurement oxidative stress-related markers. Serum samples collected evaluate lipid metabolism-associated factors. Morris water maze implemented test cognitive function rats. Rat hippocampal neurons isolated elucidate effect TAK-242 BDNF/TrkB/CREB vitro. The results showed third trimester induced neuroinflammation, metabolism disturbance, stress, impaired spatial learning memory upregulated impeded transduction hippocampus offspring; administration reversed these effects. In conclusion, late gestation impairs ability possibly by promoting neuroinflammation disturbing via TLR4/BDNF/TrkB/CREB pathway.

Language: Английский

A fluorescent probe for detecting carboxylesterase level on investigating Chinese medicine water decoction efficacy DOI
Jingyi Shi, Chaoyue Wang, Yi-Fan Xia

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 126187 - 126187

Published: April 1, 2025

Language: Английский

Citations

0
Sevoflurane anesthesia during late gestation induces cognitive disorder in rat offspring via the TLR4/BDNF/TrkB/CREB pathway DOI
Qianqian Li, Yu Qi, Zhiyi Liu

et al.

Journal of Neuropathology & Experimental Neurology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 22, 2024

Abstract Sevoflurane (Sevo) is widely used for general anesthesia during pregnancy. Emerging evidence indicates that maternal Sevo exposure can trigger developmental neurotoxicity in the offspring. Nonetheless, underlying mechanisms need further investigation. Pregnant Sprague-Dawley rats on gestational day 18 were exposed to 3.5% induce rat model of neurotoxicity. TAK-242, a TLR4 inhibitor, was administrated inhibit signaling transduction. Hippocampal tissues offspring harvested immunohistochemical staining, TUNEL Western blotting, ELISA, and measurement oxidative stress-related markers. Serum samples collected evaluate lipid metabolism-associated factors. Morris water maze implemented test cognitive function rats. Rat hippocampal neurons isolated elucidate effect TAK-242 BDNF/TrkB/CREB vitro. The results showed third trimester induced neuroinflammation, metabolism disturbance, stress, impaired spatial learning memory upregulated impeded transduction hippocampus offspring; administration reversed these effects. In conclusion, late gestation impairs ability possibly by promoting neuroinflammation disturbing via TLR4/BDNF/TrkB/CREB pathway.

Language: Английский

Citations

0