Association of TAB2 gene polymorphism with endometrial cancer susceptibility and clinical analysis DOI Open Access
Siyu Long, Yanyun Wang

Journal of Turkish Society of Obstetric and Gynecology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Transforming growth factor-β-activated kinase 1 binding protein 2 (TAB2) plays a vital role in inflammatory pathways. It has also been considered potential target for the enhancement of antiestrogen effects. Previous evidence indicated that TAB2 gene variants are associated with several diseases, whereas their correlation endometrial cancer (EC) is unclear. This study aims to initially explore association between polymorphisms (rs237028 /AG, rs521845 T/G, and rs652921 T/C) EC. Polymerase chain reaction-restriction fragment length polymorphism was applied determine genotype composition allele frequencies variant 270 EC patients 294 healthy controls. The G related increase risk [p=0.08, odds ratio (OR): 0.72, 95% confidence interval (CI): 0.56-0.91]. Moreover, different genetic models (p=0.017, OR: 0.63, CI: 0.44-0.91 codominant model; p=0.0051, 0.61, 0.43-0.87 dominant model). For rs237028, percentage AG highly differentiated tumours (G1) significantly higher than moderately, poorly (G2/G3) (p=0.031, 0.77, 0.45-1.30). Our results showed TAB2, risk, suggesting may play crucial prognosis.

Language: Английский

Anti-Neuroinflammatory Effects of Prenylated Indole Alkaloids from the Antarctic Fungus Aspergillus sp. Strain SF-7367 DOI Creative Commons
Zhiming Liu,

Chi–Su Yoon,

Thao Quyen Cao

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 294 - 294

Published: Jan. 13, 2025

Inflammation has always been considered a trigger or consequence of neurodegenerative diseases, and the inhibition inflammation in central nervous system can effectively protect nerve cells. Several studies have indicated that various natural products inhibit neuroinflammation. Among these, Antarctic fungal metabolites pharmacological activities developmental value. Therefore, this study aimed to evaluate anti-neuroinflammatory activity an fungus belonging Aspergillus (strain SF-7367). Secondary SF-7367 were isolated using high-performance liquid chromatography followed by validation their anti-inflammatory effects lipopolysaccharide-stimulated BV2 microglia RAW264.7 macrophages. Chemical analysis from strain revealed five known compounds: epideoxybrevianamide E (1), brevianamide V/W (2), K (3), Q (4), R (5). these compounds, showed significant against both cell types. Results Western blotting molecular docking could regulate activation nuclear factor kappa-light-chain-enhancer activated B (NF-κB) signaling. This indicates present sp. SF-7367) inflammatory responses reducing lipopolysaccharide-induced translocation NF-κB (p65). These findings suggest are candidate agents for treating diseases.

Language: Английский

Citations

1
Longan Aril polysaccharides ameliorate cognitive impairment in AD mice via restoration of the immune phagocytosis of microglia DOI
Han Zhang,

F.H. Tra Bi,

Peng Zhao

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 343, P. 119464 - 119464

Published: Feb. 8, 2025

Language: Английский

Citations

0
Association of TAB2 gene polymorphism with endometrial cancer susceptibility and clinical analysis DOI Open Access
Siyu Long, Yanyun Wang

Journal of Turkish Society of Obstetric and Gynecology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Transforming growth factor-β-activated kinase 1 binding protein 2 (TAB2) plays a vital role in inflammatory pathways. It has also been considered potential target for the enhancement of antiestrogen effects. Previous evidence indicated that TAB2 gene variants are associated with several diseases, whereas their correlation endometrial cancer (EC) is unclear. This study aims to initially explore association between polymorphisms (rs237028 /AG, rs521845 T/G, and rs652921 T/C) EC. Polymerase chain reaction-restriction fragment length polymorphism was applied determine genotype composition allele frequencies variant 270 EC patients 294 healthy controls. The G related increase risk [p=0.08, odds ratio (OR): 0.72, 95% confidence interval (CI): 0.56-0.91]. Moreover, different genetic models (p=0.017, OR: 0.63, CI: 0.44-0.91 codominant model; p=0.0051, 0.61, 0.43-0.87 dominant model). For rs237028, percentage AG highly differentiated tumours (G1) significantly higher than moderately, poorly (G2/G3) (p=0.031, 0.77, 0.45-1.30). Our results showed TAB2, risk, suggesting may play crucial prognosis.

Language: Английский

Citations

0