Investigation on Bowel Regulation and Constipation Relief Based on the Microbial Fermentation Solution of Cassia Seed

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119412 - 119412

Published: Jan. 1, 2025

Language: Английский

---

Exploring the Active Constituents of Andrographis paniculata in Protecting the Skin Barrier and the Synergistic Effects with Collagen XVII

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 118 - 118

Published: Jan. 20, 2025

Andrographis paniculata is mainly used to treat skin inflammations, wounds, and infections. In this study, Herba, the aerial part of plant, was proven increase viability UVB-damaged HaCat cells reduce reactive oxygen species levels. The chemical composition Herba extract (AHE) analyzed using UPLC-Q-TOF-MS, diterpene lactones were identified as its primary constituents. Then, fraction prepared exhibited similar effects AHE. AHE, component, representative constituent andrographolide all decreased expression IL-1β, IL-6, CDKN1A. Furthermore, protective AHE active ingredients on epidermal stem investigated. Notably, combined treatment with collagen XVII enhanced cells, increased stemness markers integrin β1 p63, differentiation marker keratin 10. This combination demonstrated significant synergy in maintaining homeostasis, which provides evidences for development skin-protective products.

Language: Английский

---

Photoprotective Effect and Potential Mechanisms of Gardeniae Fructus Extract in UVB-Irradiated HaCaT Cells

Cosmetics, Journal Year: 2025, Volume and Issue: 12(2), P. 72 - 72

Published: April 9, 2025

Gardeniae Fructus (GF), the desiccative mature fruitage of Gardenia jasminoides J. Ellis (G. jasminoides), is a traditional herbal medicine in China with potential value against skin photodamage. However, phytochemical basis and mechanisms underlying GF’s anti-photodamage effects remain unclear. In this study, chemical components GF extract (GFE) were analyzed using ultra-high-performance liquid chromatography coupled tandem mass spectrometry (UPLC-MS/MS), iridoids identified as main components. The antioxidant, anti-inflammatory, barrier-repair GFE UVB-induced photodamage assessed through vitro experiments. Additionally, predicted proteomics network pharmacology. results showed that significantly increased levels total superoxide dismutase (T-SOD), catalase (CAT), glutathione peroxidase (GSH-Px) induced by UVB, while decreasing reactive oxygen species (ROS) malondialdehyde (MDA) contents. also inhibited secretion interleukin-6 (IL-6) interleukin-1β (IL-1β). upregulated expression filaggrin (FLG), loricrin (LOR), involucrin (IVL) 3D epidermal models. Proteomic analysis pharmacology indicated iridoid ameliorated damage probably regulating cell cycle-related proteins signaling pathways, though requires further experimental confirmation. Overall, provide essential evidence to support development skincare active ingredient.

Language: Английский

---

The role and mechanism of β-catenin-mediated skeletal muscle satellite cells in osteoporotic fractures by Jian-Pi-Bu-Shen formula

Journal of Molecular Histology, Journal Year: 2024, Volume and Issue: 55(5), P. 875 - 893

Published: Aug. 6, 2024

Language: Английский

---

Xiyangshen Sanqi Danshen granules attenuated D-gal-induced C57BL/6J mouse aging through the AMPK/SIRT1 signaling pathway

Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156213 - 156213

Published: Nov. 17, 2024

Language: Английский

---