International review of neurobiology, Journal Year: 2024, Volume and Issue: unknown, P. 339 - 401
Published: Jan. 1, 2024
Language: Английский
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: July 29, 2024
Approximately one-third of the patients with diabetes worldwide suffer from neuropathic pain, mainly categorized by spontaneous and stimulus-induced pain. Microglia are a class immune effector cells residing in central nervous system play pivotal role diabetic pain (DNP). specifically respond to hyperglycemia along inflammatory cytokines adenosine triphosphate produced during hyperglycemic damage nerve fibers. Because presence multiple receptors on microglial surface, microglia dynamically highly responsive their immediate environment. Following peripheral sensitization caused hyperglycemia, affected cascade factors other substances accordingly, resulting change functional state for DNP pathogenesis. Inhibition such as P2X reporters, reducing cytokine expression levels reactivity mechanisms, inhibiting intracellular signaling pathways can effectively alleviate DNP. A variety drugs attenuate aforementioned processes induced reactivity. In this review, we summarize pathological mechanisms which promote maintain DNP, therapeutic techniques available, latest advances field.
Language: Английский
Citations
6
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 8, 2025
Diabetic neuropathic pain (DNP) is one of the most prevalent complications diabetes, characterized by a high global prevalence and substantial affected population with limited effective therapeutic options. Although DNP closely associated hyperglycemia, an increasing body research suggests that elevated blood glucose levels are not sole inducers DNP. The pathogenesis intricate, involving release inflammatory mediators, alterations in synaptic plasticity, demyelination nerve fibers, ectopic impulse generation, yet precise mechanisms remain to be elucidated. spinal dorsal horn coordinates dynamic interactions between peripheral central pathways, wherein neurons, microglia, astrocytes synergize Schwann cell-derived signals process nociceptive information flow. Abnormally activated neurons can alter signal transduction modifying local microenvironment, compromising myelin integrity, diminishing trophic support, leading neuronal sensitization amplifying effect on signals, which turn triggers pain. Ion channels play pivotal role conduction, modulation sodium, potassium, calcium being particularly crucial for regulation signals. In light rising incidence diabetes current scarcity treatments, thorough investigation into glial cells, especially ion channel function DNP, imperative identifying potential drug targets, developing novel strategies, thereby enhancing prospects management.
Language: Английский
Citations
0
Published: May 22, 2025
Language: Английский
Citations
0
Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e37350 - e37350
Published: Sept. 1, 2024
Neuropathic pain (NP) is a common, intractable chronic caused by nerve dysfunction and primary lesion of the nervous system. The etiology pathogenesis NP have not yet been clarified, so there lack precise effective clinical treatments. In recent years, traditional Chinese medicine (TCM) has shown increasing advantages in alleviating NP. Our review aimed to define therapeutic effect TCM (including prescriptions, extracts natural products from TCM) on reveal underlying mechanisms. Literature 2018 2024 was collected databases including Web Science, PubMed, ScienceDirect, Google academic CNKI databases. Herbal medicine, Traditional medicines (TCM), neuropathic pain, neuralgia peripheral neuropathy were used as search terms. anti-NP activity clarified propose strategies for discovering active compounds against NP, provide reference screen drugs TCM. We concluded that characteristics multi-level, multi-component, multi-target multi-pathway, which can alleviate through various pathways such anti-inflammation, anti-oxidant, anti-apoptotic pathway, regulating autophagy, intestinal flora, influencing ion channels. Based experimental study mechanism TCM, this paper offer analytical evidence support effectiveness treating These references will be helpful research development innovative with multiple levels targets. an treatment serve treasure house new drug development.
Language: Английский
Citations
3
International review of neurobiology, Journal Year: 2024, Volume and Issue: unknown, P. 339 - 401
Published: Jan. 1, 2024
Language: Английский
Citations
1