Critical role of non-coding RNA-mediated ferroptosis in urologic malignancies DOI Creative Commons
Wei Li,

Liying Zheng,

Peiyue Luo

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 31, 2024

Urologic malignancies, characterized by their high aggressiveness and metastatic potential, pose a significant public health challenge globally. Ferroptosis, novel mode of cell death, typically arises from intracellular iron ion overload the accumulation lipid peroxides. This process has been shown to play crucial regulatory role in various pathological conditions, particularly cancer, including urologic cancers. However, comprehensive mechanisms underlying ferroptosis remain poorly understood, which somewhat limits its broader application cancer therapy. Non-coding RNAs (ncRNAs), encompass microRNAs (miRNAs), long non-coding (lncRNAs), circular (circRNAs), are transcripts that pivotal roles physiological processes, such as proliferation, differentiation, apoptosis, cycle regulation, modulating expression target genes. The biological functions potential ncRNAs context cancer-related have partially elucidated. Research indicates can influence progression cancers affecting migration, drug resistance through regulation ferroptosis. Consequently, this review aims clarify ncRNA-ferroptosis axis evaluate clinical significance ferroptosis-related ncRNAs, thereby providing new insights into biology therapeutic strategies may ultimately benefit diverse range patients.

Language: Английский

Curcumin reverses cognitive deficits through promoting neurogenesis and synapse plasticity via the upregulation of PSD95 and BDNF in mice DOI Creative Commons

Gaifen Li,

Qiong Wu,

Chao Wang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 7, 2025

Following prolonged exposure to hypoxic conditions, for example, due ascent high altitude, aging or stroke, cognitive deficits can develop. The exact nature and genesis of hypoxia-induced remain unresolved. Curcumin has been reported stimulate neurogenesis reduce neuronal degeneration. This study aimed investigate the effect curcumin on in hypoxic-brain injury mice its potential mechanism. Eight-week-old male C57BL/6J were normobaric-hypoxia (13%O2) 14 days establish models. Morris water maze novel object recognition used detect function each mouse. Immunofluorescence assays, including Fluoro-Jade C (FJC) bromodeoxyuridine (BrdU), degeneration neurogenesis. Thy1-YFP transgenic synapse plasticity. Our results showed that administration rescued impaired cognition mice, shown as enhanced BrdU+ dendritic spine hippocampus. At molecular level, was found promote expression brain-derived neurotrophic factor (BDNF) postsynaptic density protein 95 (PSD95). primary hippocampal neuron detection could growth. In conclusion, our indicates curcumin, increased BDNF PSD95 contacted with interneurons, salvaged interneurons may normalize ambient neuroplasticity, resulting preservation processes well contributing improve performance.

Language: Английский

Citations

1
Advances in the Study of Necroptosis in Vascular Dementia: Focus on Blood–Brain Barrier and Neuroinflammation DOI Creative Commons

Yuemin Qiu,

Lin Cheng,

Yinyi Xiong

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Feb. 1, 2025

ABSTRACT Background Vascular dementia (VaD) includes a group of brain disorders that are characterized by cerebrovascular pathology.Neuroinflammation, disruption the blood–brain barrier (BBB) permeability, white matter lesions, and neuronal loss all significant pathological manifestations VaD play key role in disease progression. Necroptosis, also known asprogrammed necrosis, is mode programmed cell death distinct from apoptosis closely associated with ischemic injury neurodegenerative diseases. Recent studies have shown necroptosis exacerbates BBB destruction, activates neuroinflammation, promotes loss, severely affects prognosis. Results Conclusions In this review, we outline roles its molecular mechanisms process VaD, particular focus on modulating neuroinflammation exacerbating permeability elaborate regulatory centrally involved cells mediated tumor necrosis factor‐α VaD. We analyze possibility specific strategy targeting would help inhibit destruction With necroptosis, study delved into impact changes prognosis to provide new treatment ideas.

Language: Английский

Citations

1
Theoretical Framework and Emerging Challenges of Lipid Metabolism in Cancer DOI Creative Commons
Qiuying Gu, Yuan Wang, Ping Yi

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Elevated lipid metabolism is one of hallmarks malignant tumors. Lipids not only serve as essential structural components biological membranes but also provide energy and substrates for the proliferation cancer cells tumor growth. Cancer meet their needs by coordinating processes absorption, synthesis, transport, storage, catabolism. As research in this area continues to deepen, numerous new discoveries have emerged, making it crucial scientists stay informed about developments metabolism. In review, we first discuss relevant concepts theories or assumptions that help us understand -based therapies. We then systematically summarize latest advancements including mechanisms, novel targets, up-to-date pre-clinical clinical investigations anti-cancer treatment with targeted drugs. Finally, emphasize emerging directions therapeutic strategies, future prospective challenges. This review aims insights guidance field

Language: Английский

Citations

5
Critical role of non-coding RNA-mediated ferroptosis in urologic malignancies DOI Creative Commons
Wei Li,

Liying Zheng,

Peiyue Luo

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 31, 2024

Urologic malignancies, characterized by their high aggressiveness and metastatic potential, pose a significant public health challenge globally. Ferroptosis, novel mode of cell death, typically arises from intracellular iron ion overload the accumulation lipid peroxides. This process has been shown to play crucial regulatory role in various pathological conditions, particularly cancer, including urologic cancers. However, comprehensive mechanisms underlying ferroptosis remain poorly understood, which somewhat limits its broader application cancer therapy. Non-coding RNAs (ncRNAs), encompass microRNAs (miRNAs), long non-coding (lncRNAs), circular (circRNAs), are transcripts that pivotal roles physiological processes, such as proliferation, differentiation, apoptosis, cycle regulation, modulating expression target genes. The biological functions potential ncRNAs context cancer-related have partially elucidated. Research indicates can influence progression cancers affecting migration, drug resistance through regulation ferroptosis. Consequently, this review aims clarify ncRNA-ferroptosis axis evaluate clinical significance ferroptosis-related ncRNAs, thereby providing new insights into biology therapeutic strategies may ultimately benefit diverse range patients.

Language: Английский

Citations

1