Recent Developments in Citrus aurantium L.: An Overview of Bioactive Compounds, Extraction Techniques, and Technological Applications

Processes, Journal Year: 2025, Volume and Issue: 13(1), P. 120 - 120

Published: Jan. 5, 2025

This review provides an overview of recent developments in Citrus aurantium L. (sour or bitter orange), focusing on its bioactive compounds, innovative extraction techniques, and technological applications. C. is rich compounds such as flavonoids (naringin, hesperidin, kaempferol, quercetin), essential oils (β-pinene, limonene), vitamin C, which represents significant biological activities including antioxidant, antimicrobial, anti-inflammatory, anticancer effects. The discusses traditional methods, solvent hydrodistillation, alongside newer, eco-friendly approaches like ultrasound-assisted extraction, microwave-assisted supercritical fluid natural deep eutectic solvents. It also highlights cutting-edge molecular imprinting polymer-based enable the more efficient enrichment purification specific synephrine. Finally, examines diverse industrial applications these sectors foods, pharmaceuticals, cosmetics, while emphasizing growing need for sustainable technologies.

Language: Английский

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Alisol A 24-Acetate combats Methicillin-Resistant Staphylococcus aureus infection by targeting the mevalonate biosynthesis

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: 233, P. 116766 - 116766

Published: Jan. 31, 2025

Language: Английский

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Investigation of recent advancement in the pharmacological potential of C-3 substituted coumarin derivatives against S. aureus

Discover Chemistry., Journal Year: 2025, Volume and Issue: 2(1)

Published: March 26, 2025

In recent years, microbial infections have become the most common and leading cause of death worldwide. From them, Gram-positive bacterial strain Staphylococcus aureus is a highly effective pathogen that can infect almost every human body tissue, from minor skin diseases to life-threatening infections. Antibiotics are generally used treat infections, but due their excessive careless usage, microorganisms gradually developed resistance them. Therefore, it necessary develop novel drugs minimize drug resistance. Many available in market they not as before. Currently, coumarin derivatives regarded medicinal chemistry favored by new researchers diverse pharmaceutical properties, including antibacterial, anticancer, antitubercular, antioxidant, etc. It also possesses antibiotic qualities well. Coumarines commercially long been utilized clinical treatment. These therapeutic properties help antimicrobial agents Hence, this review article provides significant attention developments structure–activity relationships (SAR) C-3 substituted combat infection caused S. aureus.

Language: Английский

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In vitro and in vivo genotoxicity assessments of Ficus erecta Thunb. leaves extract support its functional and pharmaceutical potential

Drug and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: April 29, 2025

Ficus erecta Thunb. has been used to treat various inflammatory diseases owing its anti-inflammatory and antioxidative properties. However, scientific evidence on the safety of F. extract is limited. We evaluated genotoxicity ethanol (EEFE) using multiple tests. The bacterial reverse mutation (Ames) test showed that EEFE treatment five strains (Salmonella typhimurium TA98, TA100, TA1535, TA1537, Escherichia coli WP2uvrA) did not affect number revertant colonies in absence or presence S9 mix, a metabolic activator, up concentration 312.5 µg/plate. chromosomal aberrations associated with was similar negative controls, no significant increase 31.3 µg/mL EEFE. aberration assay any abnormalities combination without mix. vivo micronucleus revealed influence frequency bone marrow micronuclei 2000 mg/kg body weight male ICR mice. Moreover, changes mouse mortality rates were observed. Our study demonstrates tests, providing proof-of-concept for use as medicine functional food.

Language: Английский

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Naringenin: A potential anticancer drug

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102358 - 102358

Published: May 1, 2025

Language: Английский

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Base-Promoted Chemodivergent Construction of 2H-Chromen-2-one and Chromeno[2,3-c]pyrrole Scaffolds from para-Quinone Methides and α-Alkylidene Succinimides

Organic Letters, Journal Year: 2024, Volume and Issue: 26(42), P. 9114 - 9119

Published: Oct. 11, 2024

Herein, we evolve a base-promoted synthesis of 2

Language: Английский

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Antinociceptive In Vivo Activity and Chemical Profiling by UHPLC-MS/MS of Stem Bark and Leaves Extracts of Ficus maxima Mill. (Moraceae)

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 337, P. 118793 - 118793

Published: Sept. 7, 2024

Language: Английский

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Single Oral Toxicity Assessment and Phytochemical Analysis of the Ficus erecta Thunb. Leaf Extract

Toxicon, Journal Year: 2024, Volume and Issue: unknown, P. 108219 - 108219

Published: Dec. 1, 2024

Language: Английский

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