International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12222 - 12222
Published: Nov. 14, 2024
Helicobacter pylori is a major pathogen associated with various gastric diseases. Despite decades of research, the treatment H. remains challenging. One primary mechanisms contributing to failures therapies targeting this bacterium genetic mutations in drug target sites, although growing body scientific data highlights that efflux pumps may also take part process. Efflux are proteinaceous transporters actively expelling antimicrobial agents from interior targeted cells and reducing intracellular concentration these compounds. Considering contribute both resistance biofilm formation, an in-depth understanding their properties constitute cornerstone development novel therapeutics against pylori. In line this, aim current review describe multitude produced by present describing involvement proteins tolerance and/or classes substances.
Language: Английский