Mitophagy in Doxorubicin-Induced Cardiotoxicity: Insights into Molecular Biology and Novel Therapeutic Strategies DOI Creative Commons
Heng Zhang, Saiyang Xie, Wei Deng

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1614 - 1614

Published: Dec. 17, 2024

Doxorubicin is a chemotherapeutic drug utilized for solid tumors and hematologic malignancies, but its clinical application hampered by life-threatening cardiotoxicity, including cardiac dilation heart failure. Mitophagy, cargo-specific form of autophagy, specifically used to eliminate damaged mitochondria in autophagosomes through hydrolytic degradation following fusion with lysosomes. Recent advances have unveiled major role defective mitophagy the etiology DOX-induced cardiotoxicity. Moreover, specific interventions targeting this mechanism preserve mitochondrial function emerged as potential therapeutic strategies attenuate However, translation challenging because unclear mechanisms action pharmacological adverse effects. This review aims offer fresh perspectives on development cardiotoxicity investigate that focus improve management.

Language: Английский

Efficacy assessment of glycyrrhetinic acid-modified liposomes loaded with doxorubicin hydrochloride and cucurbitine B for synergistic treatment of hepatocellular carcinoma DOI
Muhan Chen, Xinze Liu, Lingchao Kong

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125360 - 125360

Published: Feb. 1, 2025

Language: Английский

Citations

0
Herbacetin as a Novel Ferroptosis Inhibitor for Mitigating Myocardial Damage Induced by Doxorubicin DOI
Hai Yang, Shaohong Huang,

Xinyu Heng

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Isobavachalcone confers protection against Cryptococcus neoformans-induced ferroptosis in Caenorhabditis elegans via lifespan extension and GSH-GPX-1 axis modulation DOI
Weidong Qian, Jiaxing Lu, Ting Wang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137969 - 137969

Published: March 1, 2025

Language: Английский

Citations

0
CAFFEINE EFFECT ON ECHOCARDIOGRAPHY PARAMETERS IN RATS WITH DOXORUBICIN-INDUCED CARDIOMYOPATHYS DOI Creative Commons

V. V. Mukvych,

Olena Severynovska

Bulletin of Problems Biology and Medicine, Journal Year: 2025, Volume and Issue: 1(1), P. 251 - 251

Published: Jan. 1, 2025

Language: Английский

Citations

0
Natural products and ferroptosis: A novel approach for heart failure management DOI
Zeyu Zhang, Zhihua Yang, Shuai Wang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 142, P. 156783 - 156783

Published: April 18, 2025

Language: Английский

Citations

0
Erythrocyte Membrane-Camouflaged Xanthohumol Nanoparticles Mitigate Doxorubicin-Induced Cardiotoxicity by Inhibiting Ferroptosis DOI
Jingchao Li, Yinghua Zeng, Fengjiao Liu

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Doxorubicin (DOX) chemotherapy is a cornerstone of cancer treatment, but its clinical application and effectiveness are severely restricted due to life-threatening cardiotoxicity. Xanthohumol (XH), compound from traditional Chinese medicine, noted for antioxidant properties the potential mitigate DOX-induced cardiotoxicity (DIC). However, poor water solubility results in low biocompatibility, making it susceptible immune system clearance, which restricts vivo. In this study, we first identified demonstrated that XH can effectively DIC by inhibiting ferroptosis. We designed biomimetic nanodelivery encapsulating within porous poly(lactic-co-glycolic acid) (PLGA) nanoparticles, further coated with an erythrocyte membrane (XH-NPs@RBCm). This offers several advantages, including evasion macrophage phagocytosis prolonged circulation time, thereby enhancing stability bioavailability Treatment XH-NPs@RBCm significantly reduced reactive oxygen species-dependent ferroptosis, improving myocardial atrophy cardiac dysfunction. Our study underscores therapeutic promise treating through ferroptosis inhibition, offering key insights into development management.

Language: Английский

Citations

0
Mitophagy in Doxorubicin-Induced Cardiotoxicity: Insights into Molecular Biology and Novel Therapeutic Strategies DOI Creative Commons
Heng Zhang, Saiyang Xie, Wei Deng

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1614 - 1614

Published: Dec. 17, 2024

Doxorubicin is a chemotherapeutic drug utilized for solid tumors and hematologic malignancies, but its clinical application hampered by life-threatening cardiotoxicity, including cardiac dilation heart failure. Mitophagy, cargo-specific form of autophagy, specifically used to eliminate damaged mitochondria in autophagosomes through hydrolytic degradation following fusion with lysosomes. Recent advances have unveiled major role defective mitophagy the etiology DOX-induced cardiotoxicity. Moreover, specific interventions targeting this mechanism preserve mitochondrial function emerged as potential therapeutic strategies attenuate However, translation challenging because unclear mechanisms action pharmacological adverse effects. This review aims offer fresh perspectives on development cardiotoxicity investigate that focus improve management.

Language: Английский

Citations

1