The Enigmatic Gut-Brain-Immune Trio in Brain and Behavior Disorders DOI

Rajeswara Babu Mythri

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 421 - 452

Published: Dec. 13, 2024

The human gut is a bustling colony of micro-inhabitants such as bacteria, archaea, and eukarya. These microbes inhabited the earth trillions years before humans, evolved along with have now outnumbered humans. It has been established without doubt that these microbiota within us play significant role in maintenance our physical health. They exist symbiotic and/or commensal relationship host body assist digestion, metabolism, regulation immune functions. Interestingly, recent reports suggest aliens can regulated brain behaviour too. gut-brain axis overall well-being becoming increasingly evident nurturing this connection might address many challenges targeting illnesses brain. Moreover, wake COVID-19 pandemic, more evidences unfolded suggesting impact peripheral inflammation on mental Here, importance microbes, system, their influence diseases addressed.

Language: Английский

Gut microbiota in health and disease: advances and future prospects DOI Creative Commons
Y J Zhang, Hong Wang, Yingpeng Sang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 20, 2024

Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.

Language: Английский

Citations

9
The regulatory mechanism of intermittent fasting and probiotics on cognitive function by the microbiota‐gut‐brain axis DOI
Yili Chen, Chi‐Tang Ho, Xin Zhang

et al.

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(3)

Published: March 1, 2025

Abstract Intermittent fasting (IF) is an eating pattern that promotes health and cognitive improvement through periodic eating. It has been shown to enhance neuroplasticity reduce oxidative stress inflammation. Recent studies have demonstrated probiotic supplementation enhances performance by modulating gut microbiota composition increasing short‐chain fatty acid production, which in turn neurogenesis synaptic plasticity. The microbiota‐gut‐brain axis (MGBA) the communication bridge between brain, influencing function immune, endocrine, nervous systems. combination of probiotics IF may exert complementary effects on function, with enhancing microbial diversity metabolic efficiency, while further modulate barrier integrity neurotransmitter synthesis. This review critically examines interplay via MGBA, identifying key mechanisms potential therapeutic strategies remain underexplored current research.

Language: Английский

Citations

0
Inverted day-night feeding during pregnancy affects the brain health of both maternal and fetal brains through increasing inflammation levels associated with dysbiosis of the gut microbiome in rats DOI Creative Commons
Xinyue Wang,

Xiangju Kong,

Yibo Ding

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: May 2, 2025

Language: Английский

Citations

0
The Enigmatic Gut-Brain-Immune Trio in Brain and Behavior Disorders DOI

Rajeswara Babu Mythri

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 421 - 452

Published: Dec. 13, 2024

The human gut is a bustling colony of micro-inhabitants such as bacteria, archaea, and eukarya. These microbes inhabited the earth trillions years before humans, evolved along with have now outnumbered humans. It has been established without doubt that these microbiota within us play significant role in maintenance our physical health. They exist symbiotic and/or commensal relationship host body assist digestion, metabolism, regulation immune functions. Interestingly, recent reports suggest aliens can regulated brain behaviour too. gut-brain axis overall well-being becoming increasingly evident nurturing this connection might address many challenges targeting illnesses brain. Moreover, wake COVID-19 pandemic, more evidences unfolded suggesting impact peripheral inflammation on mental Here, importance microbes, system, their influence diseases addressed.

Language: Английский

Citations

0