Redox Biology, Journal Year: 2024, Volume and Issue: 77, P. 103374 - 103374
Published: Oct. 3, 2024
Language: Английский
Frontiers in Plant Science, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 10, 2025
This study aims to investigate the impact of geographical origin on metabolite composition and bioactivity Thesium chinense Turcz. (TCT), a member Apiaceae family renowned for its wide range pharmacological properties, including antioxidant, antimicrobial, anti-inflammatory effects. In this study, we investigated whole plants TCT from different regions in China, aiming explore variation TCT. A non-targeted metabolomics approach was employed using ultra-high-performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Principal component analysis (PCA) partial least squares discriminant (PLS-DA) were utilized identify differentiate profiles. We bioactivity, antioxidant activity, total flavonoid content (TFC), characteristic compounds sourced regions. further metabolic differences quality characteristics various origins. PCA PLS-DA analyses indicated that samples origins could be clearly distinguished. The revealed 54 differential metabolites, predominantly flavonoids alkaloids. KEGG pathway significant variations biosynthesis pathways flavanols among samples. Anhui province exhibited highest TFC strongest activities, while Jilin showed lowest. strong correlation observed between origins, suggesting is significantly influenced by provenance. Additionally, activities validated, showing predictive relationship TFC. research highlights potential discerning subtleties plant metabolomes, contributing advancement traditional Chinese medicine integration into modern healthcare practices.
Language: Английский
Citations
0
Redox Biology, Journal Year: 2024, Volume and Issue: 77, P. 103374 - 103374
Published: Oct. 3, 2024
Language: Английский
Citations
0