Research progress of nano drug delivery systems in the anti-tumor treatment of traditional Chinese medicine monomers DOI Creative Commons
Bocui Song, Shuang Li, Shuang Zhang

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19332 - e19332

Published: April 24, 2025

Tumors pose a serious threat to global public health and are usually treated from two aspects: tumor cells microenvironment. Compared with traditional chemotherapy drugs, Chinese medicine (TCM) monomers have advantages in treatment, such as multiple targets, levels synergistic intervention. However, most TCM active ingredients disadvantages poor water solubility stability, which restrict their clinical application. Nano drug delivery systems the functions of improving bioavailability anti-tumor ingredients, enhancing tissue targeting, achieving controlled release, inhibiting multidrug resistance. free monomers, they higher therapeutic effects fewer side effects. This article summarizes five commonly used monomer nanocarriers, including lipid nanomaterials, exosomes, polymer micelles, carbon nanotubes, dendrimers, explains mechanisms after combining TCM, cell proliferation metastasis, regulating microenvironment, etc . At same time, potential nano combined radiotherapy immunotherapy is discussed, well current problems toxicity, long-term complex amplification process, future development directions, aiming provide reference for promoting application ingredients.

Language: Английский

Optimizing the Future: A Game Theory to Tumor Therapeutic Strategies DOI Creative Commons
Fang-Yuan Liu, Xin Liu,

Dewu Ding

et al.

Biological Procedures Online, Journal Year: 2025, Volume and Issue: 27(1)

Published: Feb. 6, 2025

Cancer poses significant economic and societal burdens on countries in the coming decades. During chemotherapy, patients frequently encounter adverse reactions. Recent research has revealed that Chinese medicine plays a crucial role mitigating side effects of chemotherapy. Therefore, this article, we propose cancer treatment process can be likened to an unequal game. To refine strategies, suggest employing Steinberg model incorporate into chemotherapy regimen for tumor treatment. We found when malignant tumors exhibit vigorous proliferation, doctors should administer conjunction with drugs, continuously optimizing therapeutic effect medicine. Upon reaching specific threshold medicine, may appropriately augment dosage building upon initial regimen. Conversely, cases where proliferation ability is weak, adjuvant therapy kept relatively balanced state. Once attains particular threshold, concurrently increased achieve superior result. From game theory perspective, devise strategies minimize drug toxicity improve outcomes by coordinating use drugs appropriate adjustments methods.

Language: Английский

Citations

0
Nanoparticle-based Traditional Chinese Medicine for Immunotherapy in Gastrointestinal Tumors DOI Creative Commons

Linjia Peng,

Yan‐Feng Liang,

Qiuli Zhang

et al.

Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
An updated review on immune checkpoint inhibitor-induced colitis: epidemiology, pathogenesis, treatment strategies, and the role of traditional Chinese medicine DOI Creative Commons
Huijing Dong, Yanmei Peng,

Xinmeng Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

Immune checkpoint inhibitor-induced colitis (irColitis) is a common and severe adverse reaction to immune inhibitors (ICIs), significantly impacting the treatment outcomes quality of life cancer patients. Epidemiological studies indicate that incidence irColitis associated with factors such as type ICIs, patient's gender, age, medical history. Although exact pathophysiology remains unclear, thought be related system activation dysregulation, gut microbiota imbalance, impaired epithelial barrier function. This review summarized epidemiology, clinical presentation, diagnostic criteria, pathogenesis irColitis. Additionally, standard novel therapeutic strategies irColitis, including corticosteroids, biologics, interventions, more importantly potential application Traditional Chinese Medicine (TCM). Future researches call for deeper mechanistic investigations, development biomarkers, reveal integration TCM therapies within individual immunotherapy frameworks.

Language: Английский

Citations

0
Rhein-induced apoptosis in colorectal cancer cell lines: A mechanistic study of the myeloid differentiation primary response gene 88/toll-like receptor 4/nuclear factor kappa-B signaling pathway DOI Open Access
Xichen Zheng, Xiaolan Zhang, Longfei Hu

et al.

CytoJournal, Journal Year: 2025, Volume and Issue: 22, P. 39 - 39

Published: April 1, 2025

Objective Colorectal cancer (CRC) remains one of the leading causes cancer-related mortality worldwide, and targeted therapies for CRC are urgently needed. This study aimed to investigate mechanisms through which rhein induces apoptosis in cells, focusing on its influence myeloid differentiation primary response gene 88 (MYD88)/toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) signaling pathway. Material Methods Cell Counting Kit-8 assay was conducted, with three non-cytotoxic concentrations selected further analysis. Cells were allocated into four groups: control, 10 μM rhein, 20 50 rhein. Migration ability evaluated wound healing assay, invasive potential assessed using Transwell invasion assay. Apoptotic rates determined terminal deoxynucleotidyl transferase dUTP nick-end labeling staining. The expression levels apoptosis-related proteins key components MYD88/TLR4/NF-κB pathway analyzed by quantitative reverse-transcription polymerase chain reaction Western blotting after treatment. Results HT-29 SW480 cells’ capacity migrate invade markedly reduced ( P < 0.05) while enhancing apoptotic 0.05). finding marked a reduction B-cell lymphoma 2 (BCL-2) protein messenger RNA (mRNA, 0.05), along notable increase Bcl-2-associated X cysteinyl aspartate-specific protease 3 mRNAs MYD88, TLR4, NF-κB substantially downregulated Adding TLR4 agonist lipopolysaccharide partially reversed inhibitory effects this pathway, thereby restoring some cellular functional behavior. Conclusion Rhein appears promote cells thus inhibiting tumor initiation progression.

Language: Английский

Citations

0
Design, synthesis and in vitro and in vivo biological evaluation of matrine derivatives as efficient anticancer agents with the characteristics of endoplasmic reticulum stress induction and apoptosis activation DOI
Xingdong Wang, Tian‐Le Xu,

Anqi Ou

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 160, P. 108482 - 108482

Published: April 16, 2025

Language: Английский

Citations

0
Research progress of nano drug delivery systems in the anti-tumor treatment of traditional Chinese medicine monomers DOI Creative Commons
Bocui Song, Shuang Li, Shuang Zhang

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19332 - e19332

Published: April 24, 2025

Tumors pose a serious threat to global public health and are usually treated from two aspects: tumor cells microenvironment. Compared with traditional chemotherapy drugs, Chinese medicine (TCM) monomers have advantages in treatment, such as multiple targets, levels synergistic intervention. However, most TCM active ingredients disadvantages poor water solubility stability, which restrict their clinical application. Nano drug delivery systems the functions of improving bioavailability anti-tumor ingredients, enhancing tissue targeting, achieving controlled release, inhibiting multidrug resistance. free monomers, they higher therapeutic effects fewer side effects. This article summarizes five commonly used monomer nanocarriers, including lipid nanomaterials, exosomes, polymer micelles, carbon nanotubes, dendrimers, explains mechanisms after combining TCM, cell proliferation metastasis, regulating microenvironment, etc . At same time, potential nano combined radiotherapy immunotherapy is discussed, well current problems toxicity, long-term complex amplification process, future development directions, aiming provide reference for promoting application ingredients.

Language: Английский

Citations

0