Barley polysaccharides modulate metabolic and mild cognitive impairment in naturally aging mice through the liver−gut−brain axis DOI

Minghao Fan,

Yefang Jiang, Chao Cai

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144008 - 144008

Published: May 1, 2025

Language: Английский

A glucan from Ganoderma lucidum: structural characterization and the anti-inflammatory effect on Parkinson's Disease via regulating dysfunctions of intestinal microecology and inhibiting TLR4/MyD88/NF-κB signaling pathway DOI
Li Chen,

Yi-Xuan Ling,

Jiaxin Sun

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 343, P. 119446 - 119446

Published: Feb. 4, 2025

Language: Английский

Citations

1
Gene Editing in Ganoderma lucidum: Development, Challenges, and Future Prospects DOI Creative Commons

Sirong He,

Yuanchao Liu, Zhang Zhi

et al.

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(4), P. 310 - 310

Published: April 14, 2025

As an emerging and innovative technology, gene-editing technology has been widely applied in crop breeding, human disease treatment, animal model research, drug vaccine development, microbial engineering. We mainly introduce the development of application clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9) Ganoderma lucidum current challenges optimization strategies use as well status breeding. Finally, future research directions that gene editing may explore breeding are prospects given existing background, directions, prospects.

Language: Английский

Citations

0
When glycobiology meets inflammasome activation: Insights and implications DOI Creative Commons
Hongliang Zhang, Tengchuan Jin, Mengzhou Xue

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Glycobiology focuses mainly on the study of glycan structures and their biological functions. Glycans not only provide a basic energy supply through tricarboxylic acid cycle glycolysis but also serve as important immune regulators during pathogen invasion homeostasis maintenance. Inflammasomes are critical multiprotein complexes system that detect both exogenous pathogenic threats endogenous danger signals to mediate inflammatory responses. has revealed significant insights into mechanisms responses, particularly in context inflammasome activation. This review summarizes multifaceted relationships between glycobiology activation, highlighting how structures, glycosylation patterns, glycan-binding proteins influence pathways. sheds light novel targets for drug development aimed at modulating pathways targeting specific structures. directly or indirectly prime activation inflammasomes, inflammasome-related by modulates downstream inflammation, interaction glycans lectins provides regulatory intersection presents unique opportunity elucidate molecular underlying responses potential therapeutic implications.

Language: Английский

Citations

0
Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional Implications DOI
Pin Gong,

Jiating Wang,

Hui Long

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

ABSTRACT This systematic review examines the antidepressant potential of edible medicinal fungi (EMFs), focusing on their bioactive compounds and mechanisms action. EMFs modulate neurotransmitter systems, including serotonin (5‐HT) dopamine (DA), alleviating depressive symptoms. Extracts from EMFs, such as Ganoderma lucidum , Hericium erinaceus Poria cocos Cordyceps militaris demonstrate significant antidepressant‐like effects in preclinical studies. Their influence tryptophan‐kynurenine (KYN) pathway, regulate hypothalamus‐pituitary‐adrenal (HPA) axis, reduce neuroinflammation, all which are linked to stress response mood regulation. The also explores gut‐brain highlighting how EMF‐derived polysaccharides improve gut health by modulating microbiota, potentially mitigating Additionally, it discusses use functional foods dietary supplements, innovations like 3D food printing for depression‐related issues, synthetic biology enhancing compound production. Artificial intelligence is used model complex mechanisms. However, challenges remain, standardization lack clinical validation. Future research should address these gaps, emphasizing personalized interventions advanced technologies next‐generation foods.

Language: Английский

Citations

0
Barley polysaccharides modulate metabolic and mild cognitive impairment in naturally aging mice through the liver−gut−brain axis DOI

Minghao Fan,

Yefang Jiang, Chao Cai

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144008 - 144008

Published: May 1, 2025

Language: Английский

Citations

0