Cited by Research Status of Traditional Chinese Medicine Intervention on TGF-<i>β</i>/Smads Pathway in the Treatment of Myocardial Fibrosis

A Network Pharmacology‐Based Strategy for Predicting Anti‐Inflammatory Targets of Zao Ren An Shen Capsule in the Treatment of Asthma DOI

Baolan Wang, Zhe Zhang, Yì Wáng

et al.

Journal of Clinical Pharmacy and Therapeutics, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Backgrounds: The Zao Ren An Shen (ZRAS) Capsule, stemming from a traditional Chinese herbal formula, is recognized as safe and effective sleep‐regulating medication. Asthma often worsens during the night early morning due to its distinct day–night rhythm, suggesting potential for ZRAS Capsule intervene in asthma attacks prognosis. Since inflammation primary mechanism asthma, exploring anti‐inflammatory effects of essential. Methods: This study identifies intersection Capsule‐related targets uncover mechanisms. Core compounds relevant genes were identified using protein–protein compound–protein interaction networks. KEGG pathway Gene Ontology analyses performed on validate their role mitigating inflammation. Binding activities between assessed western blot, qRT‐PCR, molecular docking, immunohistochemistry (IHC). Results: Key compounds, including luteolin, (S)‐Coclaurine, zizyphusine, along with IL6, TNF, MMP9, identified. Their biological processes linked IL‐17 signaling TNF pathway. Notably, inhibited mRNA protein expression MMP9. Conclusion: Regulation IL‐17/TNF likely crucial protective treatment.

Language: Английский

Citations

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